5tk8 - Revision history

OCA at 13:04, 4 October 2023

OCA — Wed, 04 Oct 2023 13:04:19 GMT

←Older revision		Revision as of 13:04, 4 October 2023
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	<StructureSection load='5tk8' size='340' side='right'caption='[[5tk8]], [[Resolution\|resolution]] 1.64Å' scene=''>		<StructureSection load='5tk8' size='340' side='right'caption='[[5tk8]], [[Resolution\|resolution]] 1.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tk8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_14581 Atcc 14581~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TK8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5TK8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tk8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Priestia_megaterium Priestia megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TK8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7D5:[(2S,3R,4R)-4-(6-AMINO-9H-PURIN-9-YL)-3-(HYDROXYMETHYL)OXETAN-2-YL]METHYL+DIHYDROGEN+PHOSPHATE'>7D5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.64Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tk6\|5tk6]], [[5tk7\|5tk7]], [[5tk9\|5tk9]], [[5tka\|5tka]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7D5:[(2S,3R,4R)-4-(6-AMINO-9H-PURIN-9-YL)-3-(HYDROXYMETHYL)OXETAN-2-YL]METHYL+DIHYDROGEN+PHOSPHATE'>7D5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">oxsA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1404 ATCC 14581])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tk8 OCA], [https://pdbe.org/5tk8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tk8 RCSB], [https://www.ebi.ac.uk/pdbsum/5tk8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tk8 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5tk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tk8 OCA], [~~http~~://pdbe.org/5tk8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5tk8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5tk8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5tk8 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O24769_PRIMG O24769_PRIMG]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 14581]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Bridwell-Rabb, J~~]]	+	[[Category: Priestia megaterium]]
-	[[Category: ~~Drennan, C L~~]]	+	[[Category: Bridwell-Rabb J]]
-	[[Category: ~~Metal binding protein]]~~	+	[[Category: Drennan CL]]
-	~~[[Category: Metalloprotein~~]]	+

OCA at 12:33, 25 December 2019

OCA — Wed, 25 Dec 2019 12:33:26 GMT

←Older revision		Revision as of 12:33, 25 December 2019
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	==Structure of the HD-domain phosphohydrolase OxsA with Oxetanocin-A monophosphate bound==		==Structure of the HD-domain phosphohydrolase OxsA with Oxetanocin-A monophosphate bound==
-	<StructureSection load='5tk8' size='340' side='right' caption='[[5tk8]], [[Resolution\|resolution]] 1.64Å' scene=''>	+	<StructureSection load='5tk8' size='340' side='right'caption='[[5tk8]], [[Resolution\|resolution]] 1.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5tk8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_14581 Atcc 14581]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TK8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5tk8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_14581 Atcc 14581]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TK8 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Atcc 14581]]		[[Category: Atcc 14581]]
		+	[[Category: Large Structures]]
	[[Category: Bridwell-Rabb, J]]		[[Category: Bridwell-Rabb, J]]
	[[Category: Drennan, C L]]		[[Category: Drennan, C L]]
	[[Category: Metal binding protein]]		[[Category: Metal binding protein]]
	[[Category: Metalloprotein]]		[[Category: Metalloprotein]]

OCA at 14:25, 6 November 2017

OCA — Mon, 06 Nov 2017 14:25:29 GMT

←Older revision		Revision as of 14:25, 6 November 2017
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	<StructureSection load='5tk8' size='340' side='right' caption='[[5tk8]], [[Resolution\|resolution]] 1.64Å' scene=''>		<StructureSection load='5tk8' size='340' side='right' caption='[[5tk8]], [[Resolution\|resolution]] 1.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tk8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TK8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tk8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_14581 Atcc 14581]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TK8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7D5:[(2S,3R,4R)-4-(6-AMINO-9H-PURIN-9-YL)-3-(HYDROXYMETHYL)OXETAN-2-YL]METHYL+DIHYDROGEN+PHOSPHATE'>7D5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7D5:[(2S,3R,4R)-4-(6-AMINO-9H-PURIN-9-YL)-3-(HYDROXYMETHYL)OXETAN-2-YL]METHYL+DIHYDROGEN+PHOSPHATE'>7D5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tk6\|5tk6]], [[5tk7\|5tk7]], [[5tk9\|5tk9]], [[5tka\|5tka]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tk6\|5tk6]], [[5tk7\|5tk7]], [[5tk9\|5tk9]], [[5tka\|5tka]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">oxsA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1404 ATCC 14581])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tk8 OCA], [http://pdbe.org/5tk8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tk8 RCSB], [http://www.ebi.ac.uk/pdbsum/5tk8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tk8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tk8 OCA], [http://pdbe.org/5tk8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tk8 RCSB], [http://www.ebi.ac.uk/pdbsum/5tk8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tk8 ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 14581]]
	[[Category: Bridwell-Rabb, J]]		[[Category: Bridwell-Rabb, J]]
	[[Category: Drennan, C L]]		[[Category: Drennan, C L]]
	[[Category: Metal binding protein]]		[[Category: Metal binding protein]]
	[[Category: Metalloprotein]]		[[Category: Metalloprotein]]

OCA at 03:31, 10 December 2016

OCA — Sat, 10 Dec 2016 03:31:40 GMT

←Older revision		Revision as of 03:31, 10 December 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5tk8 is ~~ON HOLD until Paper~~ Publication	+	==Structure of the HD-domain phosphohydrolase OxsA with Oxetanocin-A monophosphate bound==
		+	<StructureSection load='5tk8' size='340' side='right' caption='[[5tk8]], [[Resolution\|resolution]] 1.64Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5tk8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TK8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7D5:[(2S,3R,4R)-4-(6-AMINO-9H-PURIN-9-YL)-3-(HYDROXYMETHYL)OXETAN-2-YL]METHYL+DIHYDROGEN+PHOSPHATE'>7D5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tk6\|5tk6]], [[5tk7\|5tk7]], [[5tk9\|5tk9]], [[5tka\|5tka]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tk8 OCA], [http://pdbe.org/5tk8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tk8 RCSB], [http://www.ebi.ac.uk/pdbsum/5tk8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tk8 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	HD domain phosphohydrolase enzymes are characterized by a conserved set of histidine and aspartate residues that coordinate an active site metallocenter. Despite the important roles these enzymes play in nucleotide metabolism and signal transduction, few have been both biochemically and structurally characterized. Here, we present X-ray crystal structures and biochemical characterization of the Bacillus megaterium HD domain phosphohydrolase OxsA, involved in the biosynthesis of the antitumor, antiviral, and antibacterial compound oxetanocin-A. These studies reveal a previously uncharacterized reaction for this family; OxsA catalyzes the conversion of a triphosphorylated compound into a nucleoside, releasing one molecule of inorganic phosphate at a time. Remarkably, this functionality is a result of the OxsA active site, which based on structural and kinetic analyses has been tailored to bind the small, four-membered ring of oxetanocin-A over larger substrates. Furthermore, our OxsA structures show an active site that switches from a dinuclear to a mononuclear metal center as phosphates are eliminated from substrate.

-	~~Authors~~:	+	An HD domain phosphohydrolase active site tailored for oxetanocin-A biosynthesis.,Bridwell-Rabb J, Kang G, Zhong A, Liu HW, Drennan CL Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13750-13755. Epub 2016 Nov 14. PMID:27849620<ref>PMID:27849620</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5tk8" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bridwell-Rabb, J]]
		+	[[Category: Drennan, C L]]
		+	[[Category: Metal binding protein]]
		+	[[Category: Metalloprotein]]

OCA at 16:49, 2 November 2016

OCA — Wed, 02 Nov 2016 16:49:59 GMT

←Older revision		Revision as of 16:49, 2 November 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5tk8 is ON HOLD	+	The entry 5tk8 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5tk8" [edit=sysop:move=sysop]

OCA — Wed, 19 Oct 2016 15:57:22 GMT

Protected "5tk8" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:57, 19 October 2016

OCA: New page: '''Unreleased structure''' The entry 5tk8 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 19 Oct 2016 15:57:20 GMT

New page: '''Unreleased structure''' The entry 5tk8 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5tk8 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]