5tki - Revision history

OCA at 13:04, 4 October 2023

OCA — Wed, 04 Oct 2023 13:04:29 GMT

←Older revision		Revision as of 13:04, 4 October 2023
Line 1:		Line 1:

	==Neurospora crassa polysaccharide monooxygenase 2 resting state joint X-ray/neutron refinement==		==Neurospora crassa polysaccharide monooxygenase 2 resting state joint X-ray/neutron refinement==
-	<StructureSection load='5tki' size='340' side='right' caption='[[5tki]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='5tki' size='340' side='right'caption='[[5tki]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tki]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Chrysonilia_crassa Chrysonilia~~ crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TKI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5TKI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tki]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TKI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TKI FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CU:COPPER+(II)+ION'>CU</scene~~>, ~~<scene name='pdbligand=NAG:N~~-~~ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Hybrid , Neutron Diffraction , X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5tkh\|5tkh]], [[5tkf\|5tkf]], [[5tkg\|5tkg]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">G15G9.090, GE21DRAFT_7469 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5141 Chrysonilia crassa])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tki OCA], [https://pdbe.org/5tki PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tki RCSB], [https://www.ebi.ac.uk/pdbsum/5tki PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tki ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5tki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tki OCA], [~~http~~://pdbe.org/5tki PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5tki RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5tki PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5tki ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8WZQ2_NEUCS Q8WZQ2_NEUCS]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5tki" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5tki" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Monooxygenase 3D structures\|Monooxygenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chrysonilia crassa~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Dell, W B.O~~]]	+	[[Category: Neurospora crassa]]
-	[[Category: Meilleur, F]]	+	[[Category: Meilleur F]]
-	[[Category: ~~Oxidoreductase]]~~	+	[[Category: O'Dell WB]]
-	~~[[Category: Polysaccharide monooxygenase~~]]	+

OCA at 19:13, 15 November 2017

OCA — Wed, 15 Nov 2017 19:13:38 GMT

←Older revision		Revision as of 19:13, 15 November 2017
Line 3:		Line 3:
	<StructureSection load='5tki' size='340' side='right' caption='[[5tki]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='5tki' size='340' side='right' caption='[[5tki]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tki]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TKI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TKI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tki]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chrysonilia_crassa Chrysonilia crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TKI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TKI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tkh\|5tkh]], [[5tkf\|5tkf]], [[5tkg\|5tkg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tkh\|5tkh]], [[5tkf\|5tkf]], [[5tkg\|5tkg]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">G15G9.090, GE21DRAFT_7469 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5141 Chrysonilia crassa])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tki OCA], [http://pdbe.org/5tki PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tki RCSB], [http://www.ebi.ac.uk/pdbsum/5tki PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tki ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tki OCA], [http://pdbe.org/5tki PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tki RCSB], [http://www.ebi.ac.uk/pdbsum/5tki PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tki ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Chrysonilia crassa]]
	[[Category: Dell, W B.O]]		[[Category: Dell, W B.O]]
	[[Category: Meilleur, F]]		[[Category: Meilleur, F]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Polysaccharide monooxygenase]]		[[Category: Polysaccharide monooxygenase]]

OCA at 15:40, 17 May 2017

OCA — Wed, 17 May 2017 15:40:01 GMT

←Older revision		Revision as of 15:40, 17 May 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5tki is ~~ON HOLD until Oct 06 2018~~	+	==Neurospora crassa polysaccharide monooxygenase 2 resting state joint X-ray/neutron refinement==
		+	<StructureSection load='5tki' size='340' side='right' caption='[[5tki]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5tki]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TKI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TKI FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tkh\|5tkh]], [[5tkf\|5tkf]], [[5tkg\|5tkg]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tki OCA], [http://pdbe.org/5tki PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tki RCSB], [http://www.ebi.ac.uk/pdbsum/5tki PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tki ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Lytic polysaccharide monooxygenases have attracted vast attention owing to their abilities to disrupt glycosidic bonds via oxidation instead of hydrolysis and to enhance enzymatic digestion of recalcitrant substrates including chitin and cellulose. We have determined high-resolution X-ray crystal structures of an enzyme from Neurospora crassa in the resting state and of a copper(II) dioxo intermediate complex formed in the absence of substrate. X-ray crystal structures also revealed "pre-bound" molecular oxygen adjacent to the active site. An examination of protonation states enabled by neutron crystallography and density functional theory calculations identified a role for a conserved histidine in promoting oxygen activation. These results provide a new structural description of oxygen activation by substrate free lytic polysaccharide monooxygenases and provide insights that can be extended to reactivity in the enzyme-substrate complex.

-	~~Authors:~~ O'Dell, ~~W.B.~~, Meilleur, F.	+	Oxygen Activation at the Active Site of a Fungal Lytic Polysaccharide Monooxygenase.,O'Dell WB, Agarwal PK, Meilleur F Angew Chem Int Ed Engl. 2017 Jan 16;56(3):767-770. doi: 10.1002/anie.201610502., Epub 2016 Dec 22. PMID:28004877<ref>PMID:28004877</ref>

-	~~Description: Neurospora crassa polysaccharide monooxygenase 2 resting state joint X~~-~~ray~~/~~neutron refinement~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5tki" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Dell, W B.O]]
	[[Category: Meilleur, F]]		[[Category: Meilleur, F]]
-	[[Category: ~~O'Dell, W.B~~]]	+	[[Category: Oxidoreductase]]
		+	[[Category: Polysaccharide monooxygenase]]

OCA at 17:35, 9 December 2016

OCA — Fri, 09 Dec 2016 17:35:35 GMT

←Older revision		Revision as of 17:35, 9 December 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5tki is ON HOLD	+	The entry 5tki is ON HOLD until Oct 06 2018

	Authors: O'Dell, W.B., Meilleur, F.		Authors: O'Dell, W.B., Meilleur, F.

OCA: Protected "5tki" [edit=sysop:move=sysop]

OCA — Wed, 19 Oct 2016 15:58:01 GMT

Protected "5tki" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:58, 19 October 2016

OCA: New page: '''Unreleased structure''' The entry 5tki is ON HOLD Authors: O'Dell, W.B., Meilleur, F. Description: Neurospora crassa polysaccharide monooxygenase 2 resting state joint X-ray/neutron...

OCA — Wed, 19 Oct 2016 15:58:00 GMT

New page: '''Unreleased structure''' The entry 5tki is ON HOLD Authors: O'Dell, W.B., Meilleur, F. Description: Neurospora crassa polysaccharide monooxygenase 2 resting state joint X-ray/neutron...

New page

'''Unreleased structure'''

The entry 5tki is ON HOLD

Authors: O'Dell, W.B., Meilleur, F.

Description: Neurospora crassa polysaccharide monooxygenase 2 resting state joint X-ray/neutron refinement
[[Category: Unreleased Structures]]
[[Category: Meilleur, F]]
[[Category: O'Dell, W.B]]