5tlk - Revision history

OCA at 13:05, 4 October 2023

OCA — Wed, 04 Oct 2023 13:05:12 GMT

←Older revision		Revision as of 13:05, 4 October 2023
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	<StructureSection load='5tlk' size='340' side='right'caption='[[5tlk]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='5tlk' size='340' side='right'caption='[[5tlk]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tlk]] is a 10 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~] and [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TLK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5TLK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tlk]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TLK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TLK FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NAG:N~~-~~ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~PCA~~:~~PYROGLUTAMIC+ACID~~'>~~PCA~~</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat">[[5tl5\|5tl5]], [[5tlj\|5tlj]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tlk OCA], [https://pdbe.org/5tlk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tlk RCSB], [https://www.ebi.ac.uk/pdbsum/5tlk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tlk ProSAT]</span></td></tr>
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b>~~</td><td class="sblockDat">CD27, TNFRSF7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5tlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tlk OCA], [~~http~~://pdbe.org/5tlk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5tlk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5tlk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5tlk ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/CD27_HUMAN CD27_HUMAN]] Autosomal recessive lymphoproliferative disease. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/CD27_HUMAN CD27_HUMAN] Autosomal recessive lymphoproliferative disease. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CD27_HUMAN CD27_HUMAN]] Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.	+	[https://www.uniprot.org/uniprot/CD27_HUMAN CD27_HUMAN] Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Gilliland~~, G L~~]]	+	[[Category: Gilliland GL]]
-	[[Category: Malia, T]]	+	[[Category: Malia T]]
-	[[Category: Obmolova, G]]	+	[[Category: Obmolova G]]
-	[[Category: Teplyakov, A]]	+	[[Category: Teplyakov A]]
-	~~[[Category: Immune system~~]]	+

OCA at 12:13, 23 September 2020

OCA — Wed, 23 Sep 2020 12:13:45 GMT

←Older revision		Revision as of 12:13, 23 September 2020
Line 1:		Line 1:

	==COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIBODIES M2177 AND H2191==		==COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIBODIES M2177 AND H2191==
-	<StructureSection load='5tlk' size='340' side='right' caption='[[5tlk]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='5tlk' size='340' side='right'caption='[[5tlk]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tlk]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TLK OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5TLK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tlk]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TLK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5TLK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tl5\|5tl5]], [[5tlj\|5tlj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tl5\|5tl5]], [[5tlj\|5tlj]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5tlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tlk OCA], [http://pdbe.org/5tlk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tlk RCSB], [http://www.ebi.ac.uk/pdbsum/5tlk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tlk ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD27, TNFRSF7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5tlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tlk OCA], [http://pdbe.org/5tlk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tlk RCSB], [http://www.ebi.ac.uk/pdbsum/5tlk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tlk ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 22:		Line 23:
	</div>		</div>
	<div class="pdbe-citations 5tlk" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5tlk" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[T-cell receptor 3D structures\|T-cell receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Gilliland, G L]]		[[Category: Gilliland, G L]]
	[[Category: Malia, T]]		[[Category: Malia, T]]

OCA at 09:28, 10 March 2017

OCA — Fri, 10 Mar 2017 09:28:44 GMT

←Older revision		Revision as of 09:28, 10 March 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5tlk is ~~ON HOLD until Paper~~ Publication	+	==COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIBODIES M2177 AND H2191==
		+	<StructureSection load='5tlk' size='340' side='right' caption='[[5tlk]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5tlk]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TLK FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tl5\|5tl5]], [[5tlj\|5tlj]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tlk OCA], [http://pdbe.org/5tlk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tlk RCSB], [http://www.ebi.ac.uk/pdbsum/5tlk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tlk ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CD27_HUMAN CD27_HUMAN]] Autosomal recessive lymphoproliferative disease. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CD27_HUMAN CD27_HUMAN]] Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CD27 is a T and B cell co-stimulatory protein of the TNF receptor superfamily dependent on the availability of the TNF-like ligand CD70. Two anti-CD27 neutralizing monoclonal antibodies were obtained from mouse hybridoma and subsequently humanized and optimized for binding the target. The two antibodies are similar in terms of their CD27-binding affinity and ability to block NF-kappaB signaling, however their clearance rates in monkeys are very different. The pharmacokinetics profiles could be epitope dependent. To identify the epitopes, we determined the crystal structure of the ternary complex between CD27 and the Fab fragments of these non-competing antibodies. The structure reveals the binding modes of the antibodies suggesting that their mechanisms of action are distinctly different and provides a possible explanation of the in vivo data.

-	~~Authors: Teplyakov, A~~., Obmolova, G., Malia, T., ~~Gilliland~~, G.L.	+	Epitope-dependent mechanisms of CD27 neutralization revealed by X-ray crystallography.,Obmolova G, Teplyakov A, Malia TJ, Wunderler N, Kwok D, Barone L, Sweet R, Ort T, Scully M, Gilliland GL Mol Immunol. 2017 Mar;83:92-99. doi: 10.1016/j.molimm.2017.01.005. Epub 2017 Jan , 21. PMID:28119207<ref>PMID:28119207</ref>

-	~~Description~~: ~~COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIBODIES M2177 AND H2191~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5tlk" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gilliland, G L]]
	[[Category: Malia, T]]		[[Category: Malia, T]]
-	[[Category: Teplyakov, A]]
	[[Category: Obmolova, G]]		[[Category: Obmolova, G]]
-	[[Category: ~~Gilliland~~, ~~G.L~~]]	+	[[Category: Teplyakov, A]]
		+	[[Category: Immune system]]

OCA at 17:37, 9 December 2016

OCA — Fri, 09 Dec 2016 17:37:18 GMT

←Older revision		Revision as of 17:37, 9 December 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5tlk is ON HOLD	+	The entry 5tlk is ON HOLD until Paper Publication

	Authors: Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.		Authors: Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.

OCA: Protected "5tlk" [edit=sysop:move=sysop]

OCA — Wed, 19 Oct 2016 16:00:28 GMT

Protected "5tlk" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:00, 19 October 2016

OCA: New page: '''Unreleased structure''' The entry 5tlk is ON HOLD Authors: Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. Description: COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIB...

OCA — Wed, 19 Oct 2016 16:00:26 GMT

New page: '''Unreleased structure''' The entry 5tlk is ON HOLD Authors: Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. Description: COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIB...

New page

'''Unreleased structure'''

The entry 5tlk is ON HOLD

Authors: Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.

Description: COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIBODIES M2177 AND H2191
[[Category: Unreleased Structures]]
[[Category: Malia, T]]
[[Category: Teplyakov, A]]
[[Category: Obmolova, G]]
[[Category: Gilliland, G.L]]