5tnm - Revision history

OCA at 13:05, 4 October 2023

OCA — Wed, 04 Oct 2023 13:05:29 GMT

←Older revision		Revision as of 13:05, 4 October 2023
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	<StructureSection load='5tnm' size='340' side='right'caption='[[5tnm]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='5tnm' size='340' side='right'caption='[[5tnm]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tnm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Pseab Pseab~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TNM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tnm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_UCBPP-PA14 Pseudomonas aeruginosa UCBPP-PA14]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TNM FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=7F2:(2R)-octane~~-1~~,2-diol'>7F2</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;'>[[5tnd\|5tnd]]~~, ~~[[5tnf\|5tnf]], [[5tng\|5tng]], [[5tnh\|5tnh]], [[5tnk\|5tnk]], [[5tnl\|5tnl]], [[5tnn\|5tnn]], [[5tnr\|5tnr]], [[5tns\|5tns]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7F2:(2R)-octane-1,2-diol'>7F2</scene></td></tr>
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b>~~</td><td class="sblockDat">PA14_26090 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208963 PSEAB])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tnm OCA], [https://pdbe.org/5tnm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tnm RCSB], [https://www.ebi.ac.uk/pdbsum/5tnm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tnm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tnm OCA], [https://pdbe.org/5tnm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tnm RCSB], [https://www.ebi.ac.uk/pdbsum/5tnm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tnm ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0H2ZD27_PSEAB A0A0H2ZD27_PSEAB]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pseab~~]]	+	[[Category: Pseudomonas aeruginosa UCBPP-PA14]]
-	[[Category: Hvorecny~~, K L~~]]	+	[[Category: Hvorecny KL]]
-	[[Category: Madden~~, D R]]~~	+	[[Category: Madden DR]]
-	~~[[Category: Epoxide hydrolase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydroxyalkyl-enzyme intermediate~~]]	+

OCA at 11:29, 23 March 2022

OCA — Wed, 23 Mar 2022 11:29:35 GMT

←Older revision		Revision as of 11:29, 23 March 2022
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	<StructureSection load='5tnm' size='340' side='right'caption='[[5tnm]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='5tnm' size='340' side='right'caption='[[5tnm]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tnm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TNM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5TNM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tnm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseab Pseab]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TNM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7F2:(2R)-octane-1,2-diol'>7F2</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7F2:(2R)-octane-1,2-diol'>7F2</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tnd\|5tnd]], [[5tnf\|5tnf]], [[5tng\|5tng]], [[5tnh\|5tnh]], [[5tnk\|5tnk]], [[5tnl\|5tnl]], [[5tnn\|5tnn]], [[5tnr\|5tnr]], [[5tns\|5tns]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[5tnd\|5tnd]], [[5tnf\|5tnf]], [[5tng\|5tng]], [[5tnh\|5tnh]], [[5tnk\|5tnk]], [[5tnl\|5tnl]], [[5tnn\|5tnn]], [[5tnr\|5tnr]], [[5tns\|5tns]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5tnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tnm OCA], [~~http~~://pdbe.org/5tnm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5tnm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5tnm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5tnm ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA14_26090 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208963 PSEAB])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tnm OCA], [https://pdbe.org/5tnm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tnm RCSB], [https://www.ebi.ac.uk/pdbsum/5tnm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tnm ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Pseab]]
	[[Category: Hvorecny, K L]]		[[Category: Hvorecny, K L]]
	[[Category: Madden, D R]]		[[Category: Madden, D R]]

OCA at 12:14, 23 September 2020

OCA — Wed, 23 Sep 2020 12:14:26 GMT

←Older revision		Revision as of 12:14, 23 September 2020
Line 1:		Line 1:

	==Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted (R)-1,2-Epoxyoctane hydrolysis intermediate==		==Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted (R)-1,2-Epoxyoctane hydrolysis intermediate==
-	<StructureSection load='5tnm' size='340' side='right' caption='[[5tnm]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='5tnm' size='340' side='right'caption='[[5tnm]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tnm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TNM OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5TNM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tnm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TNM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5TNM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7F2:(2R)-octane-1,2-diol'>7F2</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7F2:(2R)-octane-1,2-diol'>7F2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tnd\|5tnd]], [[5tnf\|5tnf]], [[5tng\|5tng]], [[5tnh\|5tnh]], [[5tnk\|5tnk]], [[5tnl\|5tnl]], [[5tnn\|5tnn]], [[5tnr\|5tnr]], [[5tns\|5tns]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tnd\|5tnd]], [[5tnf\|5tnf]], [[5tng\|5tng]], [[5tnh\|5tnh]], [[5tnk\|5tnk]], [[5tnl\|5tnl]], [[5tnn\|5tnn]], [[5tnr\|5tnr]], [[5tns\|5tns]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5tnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tnm OCA], [http://pdbe.org/5tnm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tnm RCSB], [http://www.ebi.ac.uk/pdbsum/5tnm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tnm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5tnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tnm OCA], [http://pdbe.org/5tnm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tnm RCSB], [http://www.ebi.ac.uk/pdbsum/5tnm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tnm ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 5tnm" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5tnm" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[CFTR inhibitory factor\|CFTR inhibitory factor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Hvorecny, K L]]		[[Category: Hvorecny, K L]]
	[[Category: Madden, D R]]		[[Category: Madden, D R]]

OCA at 06:54, 11 October 2017

OCA — Wed, 11 Oct 2017 06:54:28 GMT

←Older revision		Revision as of 06:54, 11 October 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5tnm is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted (R)-1,2-Epoxyoctane hydrolysis intermediate==
		+	<StructureSection load='5tnm' size='340' side='right' caption='[[5tnm]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5tnm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TNM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TNM FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7F2:(2R)-octane-1,2-diol'>7F2</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tnd\|5tnd]], [[5tnf\|5tnf]], [[5tng\|5tng]], [[5tnh\|5tnh]], [[5tnk\|5tnk]], [[5tnl\|5tnl]], [[5tnn\|5tnn]], [[5tnr\|5tnr]], [[5tns\|5tns]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tnm OCA], [http://pdbe.org/5tnm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tnm RCSB], [http://www.ebi.ac.uk/pdbsum/5tnm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tnm ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pseudomonas aeruginosa secretes an epoxide hydrolase with catalytic activity that triggers degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) and perturbs other host defense networks. Targets of this CFTR inhibitory factor (Cif) are largely unknown, but include an epoxy-fatty acid. In this class of signaling molecules, chirality can be an important determinant of physiological output and potency. Here we explore the active-site chemistry of this two-step alpha/beta-hydrolase and its implications for an emerging class of virulence enzymes. In combination with hydrolysis data, crystal structures of 15 trapped hydroxyalkyl-enzyme intermediates reveal the stereochemical basis of Cif's substrate specificity, as well as its regioisomeric and enantiomeric preferences. The structures also reveal distinct sets of conformational changes that enable the active site to expand dramatically in two directions, accommodating a surprising array of potential physiological epoxide targets. These new substrates may contribute to Cif's diverse effects in vivo, and thus to the success of P. aeruginosa and other pathogens during infection.

-	~~Authors~~:	+	Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase.,Hvorecny KL, Bahl CD, Kitamura S, Lee KSS, Hammock BD, Morisseau C, Madden DR Structure. 2017 May 2;25(5):697-707.e4. doi: 10.1016/j.str.2017.03.002. Epub 2017, Apr 6. PMID:28392259<ref>PMID:28392259</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5tnm" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hvorecny, K L]]
		+	[[Category: Madden, D R]]
		+	[[Category: Epoxide hydrolase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydroxyalkyl-enzyme intermediate]]

OCA at 17:40, 9 December 2016

OCA — Fri, 09 Dec 2016 17:40:26 GMT

←Older revision		Revision as of 17:40, 9 December 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5tnm is ON HOLD	+	The entry 5tnm is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5tnm" [edit=sysop:move=sysop]

OCA — Wed, 26 Oct 2016 17:16:08 GMT

Protected "5tnm" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:16, 26 October 2016

OCA: New page: '''Unreleased structure''' The entry 5tnm is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 26 Oct 2016 17:16:07 GMT

New page: '''Unreleased structure''' The entry 5tnm is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5tnm is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]