5tp3 - Revision history

OCA at 13:07, 4 October 2023

OCA — Wed, 04 Oct 2023 13:07:05 GMT

←Older revision		Revision as of 13:07, 4 October 2023
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	<StructureSection load='5tp3' size='340' side='right'caption='[[5tp3]], [[Resolution\|resolution]] 1.87Å' scene=''>		<StructureSection load='5tp3' size='340' side='right'caption='[[5tp3]], [[Resolution\|resolution]] 1.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tp3]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Camelus_glama Camelus~~ glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TP3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5TP3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tp3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TP3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TP3 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5tp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tp3 OCA], [~~http~~://pdbe.org/5tp3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5tp3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5tp3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5tp3 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.874Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tp3 OCA], [https://pdbe.org/5tp3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tp3 RCSB], [https://www.ebi.ac.uk/pdbsum/5tp3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tp3 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Camelus~~ glama]]	+	[[Category: Lama glama]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gilman~~, M S.A~~]]	+	[[Category: Gilman MSA]]
-	[[Category: McLellan~~, J S~~]]	+	[[Category: McLellan JS]]
-	[[Category: Wrapp, D]]	+	[[Category: Wrapp D]]
-	~~[[Category: Fusion glycoprotein]]~~	+
-	~~[[Category: Ig fold]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Nanobody]]~~	+
-	~~[[Category: Pseudomerohedral]]~~	+
-	~~[[Category: Respiratory syncytial virus~~]]	+

OCA at 12:34, 25 December 2019

OCA — Wed, 25 Dec 2019 12:34:34 GMT

←Older revision		Revision as of 12:34, 25 December 2019
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	==Crystal structure of the RSV-neutralizing single-domain antibody F-VHH-4==		==Crystal structure of the RSV-neutralizing single-domain antibody F-VHH-4==
-	<StructureSection load='5tp3' size='340' side='right' caption='[[5tp3]], [[Resolution\|resolution]] 1.87Å' scene=''>	+	<StructureSection load='5tp3' size='340' side='right'caption='[[5tp3]], [[Resolution\|resolution]] 1.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tp3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TP3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TP3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tp3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TP3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TP3 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tp3 OCA], [http://pdbe.org/5tp3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tp3 RCSB], [http://www.ebi.ac.uk/pdbsum/5tp3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tp3 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tp3 OCA], [http://pdbe.org/5tp3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tp3 RCSB], [http://www.ebi.ac.uk/pdbsum/5tp3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tp3 ProSAT]</span></td></tr>
	</table>		</table>
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	</div>		</div>
	<div class="pdbe-citations 5tp3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5tp3" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Camelus glama]]
		+	[[Category: Large Structures]]
	[[Category: Gilman, M S.A]]		[[Category: Gilman, M S.A]]
	[[Category: McLellan, J S]]		[[Category: McLellan, J S]]

OCA at 07:08, 9 March 2017

OCA — Thu, 09 Mar 2017 07:08:27 GMT

←Older revision		Revision as of 07:08, 9 March 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5tp3 is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of the RSV-neutralizing single-domain antibody F-VHH-4==
		+	<StructureSection load='5tp3' size='340' side='right' caption='[[5tp3]], [[Resolution\|resolution]] 1.87Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5tp3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TP3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TP3 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tp3 OCA], [http://pdbe.org/5tp3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tp3 RCSB], [http://www.ebi.ac.uk/pdbsum/5tp3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tp3 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human respiratory syncytial virus (RSV) is the main cause of lower respiratory tract infections in young children. The RSV fusion protein (F) is highly conserved and is the only viral membrane protein that is essential for infection. The prefusion conformation of RSV F is considered the most relevant target for antiviral strategies because it is the fusion-competent form of the protein and the primary target of neutralizing activity present in human serum. Here, we describe two llama-derived single-domain antibodies (VHHs) that have potent RSV-neutralizing activity and bind selectively to prefusion RSV F with picomolar affinity. Crystal structures of these VHHs in complex with prefusion F show that they recognize a conserved cavity formed by two F protomers. In addition, the VHHs prevent RSV replication and lung infiltration of inflammatory monocytes and T cells in RSV-challenged mice. These prefusion F-specific VHHs represent promising antiviral agents against RSV.

-	~~Authors~~:	+	Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.,Rossey I, Gilman MS, Kabeche SC, Sedeyn K, Wrapp D, Kanekiyo M, Chen M, Mas V, Spitaels J, Melero JA, Graham BS, Schepens B, McLellan JS, Saelens X Nat Commun. 2017 Feb 13;8:14158. doi: 10.1038/ncomms14158. PMID:28194013<ref>PMID:28194013</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5tp3" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gilman, M S.A]]
		+	[[Category: McLellan, J S]]
		+	[[Category: Wrapp, D]]
		+	[[Category: Fusion glycoprotein]]
		+	[[Category: Ig fold]]
		+	[[Category: Immune system]]
		+	[[Category: Nanobody]]
		+	[[Category: Pseudomerohedral]]
		+	[[Category: Respiratory syncytial virus]]

OCA at 17:42, 9 December 2016

OCA — Fri, 09 Dec 2016 17:42:56 GMT

←Older revision		Revision as of 17:42, 9 December 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5tp3 is ON HOLD	+	The entry 5tp3 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5tp3" [edit=sysop:move=sysop]

OCA — Wed, 26 Oct 2016 17:20:21 GMT

Protected "5tp3" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:20, 26 October 2016

OCA: New page: '''Unreleased structure''' The entry 5tp3 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 26 Oct 2016 17:20:19 GMT

New page: '''Unreleased structure''' The entry 5tp3 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5tp3 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]