5tt3 - Revision history

OCA at 13:11, 4 October 2023

OCA — Wed, 04 Oct 2023 13:11:17 GMT

←Older revision		Revision as of 13:11, 4 October 2023
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	<StructureSection load='5tt3' size='340' side='right'caption='[[5tt3]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5tt3' size='340' side='right'caption='[[5tt3]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tt3]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TT3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5TT3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tt3]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_26695 Helicobacter pylori 26695]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TT3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EZL:6-ETHOXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE'>EZL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tt8\|5tt8]], [[5tuo\|5tuo]], [[5tv3\|5tv3]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EZL:6-ETHOXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE'>EZL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5tt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tt3 OCA], [~~http~~://pdbe.org/5tt3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5tt3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5tt3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5tt3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tt3 OCA], [https://pdbe.org/5tt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tt3 RCSB], [https://www.ebi.ac.uk/pdbsum/5tt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tt3 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0M3KL20_HELPY A0A0M3KL20_HELPY]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Helicobacter pylori 26695]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Modak~~, J K~~]]	+	[[Category: Modak JK]]
-	[[Category: Roujeinikova, A]]	+	[[Category: Roujeinikova A]]
-	~~[[Category: Alpha-carbonic anhydrase]]~~	+
-	~~[[Category: Helicobacter pylori]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Periplasm]]~~	+
-	~~[[Category: Zinc]]~~	+
-	~~[[Category: Zinc metalloenzyme~~]]	+

OCA at 12:19, 23 September 2020

OCA — Wed, 23 Sep 2020 12:19:20 GMT

←Older revision		Revision as of 12:19, 23 September 2020
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	==Crystal structure of the complex of Helicobacter pylori alpha-carbonic anhydrase with ethoxzolamide==		==Crystal structure of the complex of Helicobacter pylori alpha-carbonic anhydrase with ethoxzolamide==
-	<StructureSection load='5tt3' size='340' side='right' caption='[[5tt3]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='5tt3' size='340' side='right'caption='[[5tt3]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tt3]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TT3 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5TT3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tt3]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TT3 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5TT3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EZL:6-ETHOXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE'>EZL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EZL:6-ETHOXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE'>EZL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tt8\|5tt8]], [[5tuo\|5tuo]], [[5tv3\|5tv3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tt8\|5tt8]], [[5tuo\|5tuo]], [[5tv3\|5tv3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5tt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tt3 OCA], [http://pdbe.org/5tt3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tt3 RCSB], [http://www.ebi.ac.uk/pdbsum/5tt3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tt3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5tt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tt3 OCA], [http://pdbe.org/5tt3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tt3 RCSB], [http://www.ebi.ac.uk/pdbsum/5tt3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tt3 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 5tt3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5tt3" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Modak, J K]]		[[Category: Modak, J K]]
	[[Category: Roujeinikova, A]]		[[Category: Roujeinikova, A]]

OCA at 10:27, 13 September 2017

OCA — Wed, 13 Sep 2017 10:27:50 GMT

←Older revision		Revision as of 10:27, 13 September 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5tt3 is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of the complex of Helicobacter pylori alpha-carbonic anhydrase with ethoxzolamide==
		+	<StructureSection load='5tt3' size='340' side='right' caption='[[5tt3]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5tt3]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TT3 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EZL:6-ETHOXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE'>EZL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tt8\|5tt8]], [[5tuo\|5tuo]], [[5tv3\|5tv3]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tt3 OCA], [http://pdbe.org/5tt3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tt3 RCSB], [http://www.ebi.ac.uk/pdbsum/5tt3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tt3 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	alpha-Carbonic anhydrase of Helicobacter pylori (HpalphaCA) plays an important role in the acclimation of this oncobacterium to the acidic pH of the stomach. Sulfonamide inhibitors of HpalphaCA possess anti-H. pylori activity. The crystal structures of complexes of HpalphaCA with a family of acetazolamide-related sulfonamides have been determined. Analysis of the structures revealed that the mode of sulfonamide binding correlates well with their inhibitory activities. In addition, comparisons with the corresponding inhibitor complexes of human carbonic anhydrase II (HCAII) indicated that HpalphaCA possesses an additional, alternative binding site for sulfonamides that is not present in HCAII. Furthermore, the hydrophobic pocket in HCAII that stabilizes the apolar moiety of sulfonamide inhibitors is replaced with a more open, hydrophilic pocket in HpalphaCA. Thus, our analysis identified major structural features can be exploited in the design of selective and more potent inhibitors of HpalphaCA that may lead to novel antimicrobials.

-	~~Authors:~~ Modak, J.K., ~~Roujeinikova, A~~.	+	Structure-Activity Relationship for Sulfonamide Inhibition of Helicobacter pylori alpha-Carbonic Anhydrase.,Modak JK, Liu YC, Supuran CT, Roujeinikova A J Med Chem. 2016 Dec 22;59(24):11098-11109. doi: 10.1021/acs.jmedchem.6b01333., Epub 2016 Dec 8. PMID:28002963<ref>PMID:28002963</ref>

-	~~Description: Crystal structure~~ of the ~~complex~~ of ~~Helicobacter pylori alpha~~-~~carbonic anhydrase with ethoxzolamide~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5tt3" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Modak, J K]]
	[[Category: Roujeinikova, A]]		[[Category: Roujeinikova, A]]
-	[[Category: ~~Modak, J.K~~]]	+	[[Category: Alpha-carbonic anhydrase]]
		+	[[Category: Helicobacter pylori]]
		+	[[Category: Lyase]]
		+	[[Category: Periplasm]]
		+	[[Category: Zinc]]
		+	[[Category: Zinc metalloenzyme]]

OCA at 13:47, 9 March 2017

OCA — Thu, 09 Mar 2017 13:47:00 GMT

←Older revision		Revision as of 13:47, 9 March 2017
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	Description: Crystal structure of the complex of Helicobacter pylori alpha-carbonic anhydrase with ethoxzolamide		Description: Crystal structure of the complex of Helicobacter pylori alpha-carbonic anhydrase with ethoxzolamide
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Modak, J.K]]
	[[Category: Roujeinikova, A]]		[[Category: Roujeinikova, A]]
		+	[[Category: Modak, J.K]]

OCA: Protected "5tt3" [edit=sysop:move=sysop]

OCA — Fri, 09 Dec 2016 17:50:20 GMT

Protected "5tt3" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:50, 9 December 2016

OCA: New page: '''Unreleased structure''' The entry 5tt3 is ON HOLD until Paper Publication Authors: Modak, J.K., Roujeinikova, A. Description: Crystal structure of the complex of Helicobacter pylori...

OCA — Fri, 09 Dec 2016 17:50:19 GMT

New page: '''Unreleased structure''' The entry 5tt3 is ON HOLD until Paper Publication Authors: Modak, J.K., Roujeinikova, A. Description: Crystal structure of the complex of Helicobacter pylori...

New page

'''Unreleased structure'''

The entry 5tt3 is ON HOLD until Paper Publication

Authors: Modak, J.K., Roujeinikova, A.

Description: Crystal structure of the complex of Helicobacter pylori alpha-carbonic anhydrase with ethoxzolamide
[[Category: Unreleased Structures]]
[[Category: Modak, J.K]]
[[Category: Roujeinikova, A]]