5ttj - Revision history

OCA at 14:23, 6 March 2024

OCA — Wed, 06 Mar 2024 14:23:10 GMT

←Older revision		Revision as of 14:23, 6 March 2024
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	<StructureSection load='5ttj' size='340' side='right'caption='[[5ttj]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5ttj' size='340' side='right'caption='[[5ttj]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ttj]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Psep6 Psep6~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TTJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5TTJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ttj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_putida_S16 Pseudomonas putida S16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TTJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TTJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=FAD:FLAVIN~~-~~ADENINE+DINUCLEOTIDE'>FAD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5ttk\|5ttk]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">PPS_4081 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1042876 PSEP6])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ttj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ttj OCA], [https://pdbe.org/5ttj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ttj RCSB], [https://www.ebi.ac.uk/pdbsum/5ttj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ttj ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ttj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ttj OCA], [~~http~~://pdbe.org/5ttj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ttj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ttj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ttj ProSAT]</span></td></tr>	+
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/F8G0P2_PSEP6 F8G0P2_PSEP6]
-	The first structure of nicotine oxidoreductase (NicA2) was determined by X-ray crystallography. Pseudomonas putida has evolved nicotine-degrading activity to provide a source of carbon and nitrogen. The structure establishes NicA2 as a member of the monoamine oxidase family. Residues 1-50 are disordered and may play a role in localization. The nicotine-binding site proximal to the isoalloxazine ring of flavin shows an unusual composition of the classical aromatic cage (W427 and N462). The active site architecture is consistent with the proposed binding of the deprotonated form of the substrate and the flavin-dependent oxidation of the pyrrolidone C-N bond followed by nonenzymatic hydrolysis.	+
-		+
-	~~Structural Analysis Provides Mechanistic Insight into Nicotine Oxidoreductase from Pseudomonas putida.,Tararina MA, Janda KD, Allen KN Biochemistry. 2016 Dec 6;55(48)~~:~~6595-6598. Epub 2016 Nov 18. PMID:27933790<ref>PMID:27933790<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®~~/~~PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 5ttj" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Psep6~~]]	+	[[Category: Pseudomonas putida S16]]
-	[[Category: Allen~~, K N~~]]	+	[[Category: Allen KN]]
-	[[Category: Janda~~, K D~~]]	+	[[Category: Janda KD]]
-	[[Category: Tararina~~, M A]]~~	+	[[Category: Tararina MA]]
-	~~[[Category: Flavoenzyme]]~~	+
-	~~[[Category: Monoamine oxidase family]]~~	+
-	~~[[Category: Nicotine degradation]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Phbh fold~~]]	+

OCA at 16:58, 11 December 2019

OCA — Wed, 11 Dec 2019 16:58:57 GMT

←Older revision		Revision as of 16:58, 11 December 2019
Line 1:		Line 1:

	==Crystal Structure of Nicotine Oxidoreductase from Pseudomonas putida==		==Crystal Structure of Nicotine Oxidoreductase from Pseudomonas putida==
-	<StructureSection load='5ttj' size='340' side='right' caption='[[5ttj]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='5ttj' size='340' side='right'caption='[[5ttj]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ttj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Psep6 Psep6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TTJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TTJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ttj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Psep6 Psep6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TTJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TTJ FirstGlance]. <br>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Psep6]]		[[Category: Psep6]]
	[[Category: Allen, K N]]		[[Category: Allen, K N]]

OCA at 06:31, 18 April 2018

OCA — Wed, 18 Apr 2018 06:31:46 GMT

←Older revision		Revision as of 06:31, 18 April 2018
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ttj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ttj OCA], [http://pdbe.org/5ttj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ttj RCSB], [http://www.ebi.ac.uk/pdbsum/5ttj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ttj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ttj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ttj OCA], [http://pdbe.org/5ttj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ttj RCSB], [http://www.ebi.ac.uk/pdbsum/5ttj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ttj ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The first structure of nicotine oxidoreductase (NicA2) was determined by X-ray crystallography. Pseudomonas putida has evolved nicotine-degrading activity to provide a source of carbon and nitrogen. The structure establishes NicA2 as a member of the monoamine oxidase family. Residues 1-50 are disordered and may play a role in localization. The nicotine-binding site proximal to the isoalloxazine ring of flavin shows an unusual composition of the classical aromatic cage (W427 and N462). The active site architecture is consistent with the proposed binding of the deprotonated form of the substrate and the flavin-dependent oxidation of the pyrrolidone C-N bond followed by nonenzymatic hydrolysis.
		+
		+	Structural Analysis Provides Mechanistic Insight into Nicotine Oxidoreductase from Pseudomonas putida.,Tararina MA, Janda KD, Allen KN Biochemistry. 2016 Dec 6;55(48):6595-6598. Epub 2016 Nov 18. PMID:27933790<ref>PMID:27933790</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5ttj" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 14:27, 6 November 2017

OCA — Mon, 06 Nov 2017 14:27:13 GMT

←Older revision		Revision as of 14:27, 6 November 2017
Line 3:		Line 3:
	<StructureSection load='5ttj' size='340' side='right' caption='[[5ttj]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5ttj' size='340' side='right' caption='[[5ttj]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ttj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TTJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TTJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ttj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Psep6 Psep6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TTJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TTJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ttk\|5ttk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ttk\|5ttk]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPS_4081 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1042876 PSEP6])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ttj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ttj OCA], [http://pdbe.org/5ttj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ttj RCSB], [http://www.ebi.ac.uk/pdbsum/5ttj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ttj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ttj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ttj OCA], [http://pdbe.org/5ttj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ttj RCSB], [http://www.ebi.ac.uk/pdbsum/5ttj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ttj ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Psep6]]
	[[Category: Allen, K N]]		[[Category: Allen, K N]]
	[[Category: Janda, K D]]		[[Category: Janda, K D]]

OCA at 09:28, 10 March 2017

OCA — Fri, 10 Mar 2017 09:28:57 GMT

←Older revision		Revision as of 09:28, 10 March 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ttj is ~~ON HOLD~~	+	==Crystal Structure of Nicotine Oxidoreductase from Pseudomonas putida==
-		+	<StructureSection load='5ttj' size='340' side='right' caption='[[5ttj]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~Authors~~: ~~Tararina~~, M.A., ~~Janda~~, K.D., ~~Allen~~, K.N.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5ttj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TTJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TTJ FirstGlance]. <br>
-	~~Description: Crystal Structure of Nicotine Oxidoreductase from Pseudomonas putida~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ttk\|5ttk]]</td></tr>
-	[[Category: Janda, K.D]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ttj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ttj OCA], [http://pdbe.org/5ttj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ttj RCSB], [http://www.ebi.ac.uk/pdbsum/5ttj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ttj ProSAT]</span></td></tr>
-	[[Category: Tararina, M.A]]	+	</table>
-	[[Category: ~~Allen, K.N~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Allen, K N]]
		+	[[Category: Janda, K D]]
		+	[[Category: Tararina, M A]]
		+	[[Category: Flavoenzyme]]
		+	[[Category: Monoamine oxidase family]]
		+	[[Category: Nicotine degradation]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Phbh fold]]

OCA: Protected "5ttj" [edit=sysop:move=sysop]

OCA — Fri, 09 Dec 2016 17:51:32 GMT

Protected "5ttj" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:51, 9 December 2016

OCA: New page: '''Unreleased structure''' The entry 5ttj is ON HOLD Authors: Tararina, M.A., Janda, K.D., Allen, K.N. Description: Crystal Structure of Nicotine Oxidoreductase from Pseudomonas putida...

OCA — Fri, 09 Dec 2016 17:51:30 GMT

New page: '''Unreleased structure''' The entry 5ttj is ON HOLD Authors: Tararina, M.A., Janda, K.D., Allen, K.N. Description: Crystal Structure of Nicotine Oxidoreductase from Pseudomonas putida...

New page

'''Unreleased structure'''

The entry 5ttj is ON HOLD

Authors: Tararina, M.A., Janda, K.D., Allen, K.N.

Description: Crystal Structure of Nicotine Oxidoreductase from Pseudomonas putida
[[Category: Unreleased Structures]]
[[Category: Janda, K.D]]
[[Category: Tararina, M.A]]
[[Category: Allen, K.N]]