5tua - Revision history

OCA at 13:12, 4 October 2023

OCA — Wed, 04 Oct 2023 13:12:18 GMT

←Older revision		Revision as of 13:12, 4 October 2023
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	<StructureSection load='5tua' size='340' side='right'caption='[[5tua]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='5tua' size='340' side='right'caption='[[5tua]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tua]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TUA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5TUA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tua]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TUA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TUA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.3Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TPC1, CCH1, FOU2, At4g03560, F9H3.19, T5L23.5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5tua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tua OCA], [~~http~~://pdbe.org/5tua PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5tua RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5tua PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5tua ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tua OCA], [https://pdbe.org/5tua PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tua RCSB], [https://www.ebi.ac.uk/pdbsum/5tua PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tua ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TPC1_ARATH TPC1_ARATH]] Functions as a voltage-gated inward-rectifying Ca(2+) channel (VDCC) across the vacuole membrane. Is one of the essential components of the slow vacuolar (SV) channel. Acts as the major ROS-responsive Ca(2+) channel and is the possible target of Al-dependent inhibition. Involved in the regulation of germination and stomatal movement.<ref>PMID:15464979</ref> <ref>PMID:15772667</ref>	+	[https://www.uniprot.org/uniprot/TPC1_ARATH TPC1_ARATH] Functions as a voltage-gated inward-rectifying Ca(2+) channel (VDCC) across the vacuole membrane. Is one of the essential components of the slow vacuolar (SV) channel. Acts as the major ROS-responsive Ca(2+) channel and is the possible target of Al-dependent inhibition. Involved in the regulation of germination and stomatal movement.<ref>PMID:15464979</ref> <ref>PMID:15772667</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath~~]]	+	[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Guo, J]]	+	[[Category: Guo J]]
-	[[Category: Jiang, Y]]	+	[[Category: Jiang Y]]
-	[[Category: Zeng, W]]	+	[[Category: Zeng W]]
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Metal transport]]~~	+
-	~~[[Category: Na+-selective]]~~	+
-	~~[[Category: Two-pore channel~~]]	+

OCA at 16:42, 20 November 2019

OCA — Wed, 20 Nov 2019 16:42:14 GMT

←Older revision		Revision as of 16:42, 20 November 2019
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	==structure of a Na+-selective mutant of two-pore channel from Arabidopsis thaliana AtTPC1==		==structure of a Na+-selective mutant of two-pore channel from Arabidopsis thaliana AtTPC1==
-	<StructureSection load='5tua' size='340' side='right' caption='[[5tua]], [[Resolution\|resolution]] 3.30Å' scene=''>	+	<StructureSection load='5tua' size='340' side='right'caption='[[5tua]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5tua]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TUA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TUA FirstGlance]. <br>		<table><tr><td colspan='2'>[[5tua]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TUA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TUA FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 5tua" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5tua" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Arath]]		[[Category: Arath]]
		+	[[Category: Large Structures]]
	[[Category: Guo, J]]		[[Category: Guo, J]]
	[[Category: Jiang, Y]]		[[Category: Jiang, Y]]

OCA at 19:19, 15 November 2017

OCA — Wed, 15 Nov 2017 19:19:51 GMT

←Older revision		Revision as of 19:19, 15 November 2017
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	<StructureSection load='5tua' size='340' side='right' caption='[[5tua]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='5tua' size='340' side='right' caption='[[5tua]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tua]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TUA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TUA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tua]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TUA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TUA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TPC1, CCH1, FOU2, At4g03560, F9H3.19, T5L23.5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tua OCA], [http://pdbe.org/5tua PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tua RCSB], [http://www.ebi.ac.uk/pdbsum/5tua PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tua ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tua OCA], [http://pdbe.org/5tua PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tua RCSB], [http://www.ebi.ac.uk/pdbsum/5tua PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tua ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arath]]
	[[Category: Guo, J]]		[[Category: Guo, J]]
	[[Category: Jiang, Y]]		[[Category: Jiang, Y]]

OCA at 10:47, 1 February 2017

OCA — Wed, 01 Feb 2017 10:47:41 GMT

←Older revision		Revision as of 10:47, 1 February 2017
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TPC1_ARATH TPC1_ARATH]] Functions as a voltage-gated inward-rectifying Ca(2+) channel (VDCC) across the vacuole membrane. Is one of the essential components of the slow vacuolar (SV) channel. Acts as the major ROS-responsive Ca(2+) channel and is the possible target of Al-dependent inhibition. Involved in the regulation of germination and stomatal movement.<ref>PMID:15464979</ref> <ref>PMID:15772667</ref>		[[http://www.uniprot.org/uniprot/TPC1_ARATH TPC1_ARATH]] Functions as a voltage-gated inward-rectifying Ca(2+) channel (VDCC) across the vacuole membrane. Is one of the essential components of the slow vacuolar (SV) channel. Acts as the major ROS-responsive Ca(2+) channel and is the possible target of Al-dependent inhibition. Involved in the regulation of germination and stomatal movement.<ref>PMID:15464979</ref> <ref>PMID:15772667</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Organellar two-pore channels (TPCs) contain two copies of a Shaker-like six-transmembrane (6-TM) domain in each subunit and are ubiquitously expressed in plants and animals. Interestingly, plant and animal TPCs share high sequence similarity in the filter region, yet exhibit drastically different ion selectivity. Plant TPC1 functions as a nonselective cation channel on the vacuole membrane, whereas mammalian TPC channels have been shown to be endo/lysosomal Na+-selective or Ca2+-release channels. In this study, we performed systematic characterization of the ion selectivity of TPC1 from Arabidopsis thaliana (AtTPC1) and compared its selectivity with the selectivity of human TPC2 (HsTPC2). We demonstrate that AtTPC1 is selective for Ca2+ over Na+, but nonselective among monovalent cations (Li+, Na+, and K+). Our results also confirm that HsTPC2 is a Na+-selective channel activated by phosphatidylinositol 3,5-bisphosphate. Guided by our recent structure of AtTPC1, we converted AtTPC1 to a Na+-selective channel by mimicking the selectivity filter of HsTPC2 and identified key residues in the TPC filters that differentiate the selectivity between AtTPC1 and HsTPC2. Furthermore, the structure of the Na+-selective AtTPC1 mutant elucidates the structural basis for Na+ selectivity in mammalian TPCs.
		+
		+	Tuning the ion selectivity of two-pore channels.,Guo J, Zeng W, Jiang Y Proc Natl Acad Sci U S A. 2017 Jan 17. pii: 201616191. doi:, 10.1073/pnas.1616191114. PMID:28096396<ref>PMID:28096396</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5tua" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 00:50, 19 January 2017

OCA — Thu, 19 Jan 2017 00:50:29 GMT

←Older revision		Revision as of 00:50, 19 January 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5tua is ~~ON HOLD~~ ~~until Paper Publication~~	+	==structure of a Na+-selective mutant of two-pore channel from Arabidopsis thaliana AtTPC1==
-		+	<StructureSection load='5tua' size='340' side='right' caption='[[5tua]], [[Resolution\|resolution]] 3.30Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5tua]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TUA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TUA FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tua OCA], [http://pdbe.org/5tua PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tua RCSB], [http://www.ebi.ac.uk/pdbsum/5tua PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tua ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TPC1_ARATH TPC1_ARATH]] Functions as a voltage-gated inward-rectifying Ca(2+) channel (VDCC) across the vacuole membrane. Is one of the essential components of the slow vacuolar (SV) channel. Acts as the major ROS-responsive Ca(2+) channel and is the possible target of Al-dependent inhibition. Involved in the regulation of germination and stomatal movement.<ref>PMID:15464979</ref> <ref>PMID:15772667</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Guo, J]]
		+	[[Category: Jiang, Y]]
		+	[[Category: Zeng, W]]
		+	[[Category: Membrane protein]]
		+	[[Category: Metal transport]]
		+	[[Category: Na+-selective]]
		+	[[Category: Two-pore channel]]

OCA: Protected "5tua" [edit=sysop:move=sysop]

OCA — Fri, 09 Dec 2016 17:52:59 GMT

Protected "5tua" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:52, 9 December 2016

OCA: New page: '''Unreleased structure''' The entry 5tua is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Fri, 09 Dec 2016 17:52:58 GMT

New page: '''Unreleased structure''' The entry 5tua is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5tua is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]