5tw5 - Revision history

OCA at 13:14, 4 October 2023

OCA — Wed, 04 Oct 2023 13:14:42 GMT

←Older revision		Revision as of 13:14, 4 October 2023
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	<StructureSection load='5tw5' size='340' side='right'caption='[[5tw5]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='5tw5' size='340' side='right'caption='[[5tw5]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tw5]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TW5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5TW5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tw5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TW5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7LM:N-[(2S,3S,4R)-1-(alpha-D-galactopyranosyloxy)-3,4-dihydroxy-16-phenylhexadecan-2-yl]octanamide'>7LM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tw2\|5tw2]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7LM:N-[(2S,3S,4R)-1-(alpha-D-galactopyranosyloxy)-3,4-dihydroxy-16-phenylhexadecan-2-yl]octanamide'>7LM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cd1d1, Cd1.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tw5 OCA], [https://pdbe.org/5tw5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tw5 RCSB], [https://www.ebi.ac.uk/pdbsum/5tw5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tw5 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5tw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tw5 OCA], [~~http~~://pdbe.org/5tw5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5tw5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5tw5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5tw5 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CD1D1_MOUSE CD1D1_MOUSE]] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:11754812</ref> <ref>PMID:16314439</ref> <ref>PMID:16007091</ref> ~~[[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.~~	+	[https://www.uniprot.org/uniprot/CD1D1_MOUSE CD1D1_MOUSE] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:11754812</ref> <ref>PMID:16314439</ref> <ref>PMID:16007091</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]		*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
		+	*[[CD1\|CD1]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Wang, J]]	+	[[Category: Wang J]]
-	[[Category: Zajonc~~, D M]]~~	+	[[Category: Zajonc DM]]
-	~~[[Category: Antigen-presentation]]~~	+
-	~~[[Category: Glycolipid]]~~	+
-	~~[[Category: Immune system-inhibitor complex]]~~	+
-	~~[[Category: Mhc fold]]~~	+
-	~~[[Category: T cell~~]]	+

OCA at 12:21, 23 September 2020

OCA — Wed, 23 Sep 2020 12:21:21 GMT

←Older revision		Revision as of 12:21, 23 September 2020
Line 1:		Line 1:

	==Structure of mouse CD1d with bound glycosphingolipid JJ112==		==Structure of mouse CD1d with bound glycosphingolipid JJ112==
-	<StructureSection load='5tw5' size='340' side='right' caption='[[5tw5]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='5tw5' size='340' side='right'caption='[[5tw5]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tw5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TW5 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5TW5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tw5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TW5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5TW5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7LM:N-[(2S,3S,4R)-1-(alpha-D-galactopyranosyloxy)-3,4-dihydroxy-16-phenylhexadecan-2-yl]octanamide'>7LM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7LM:N-[(2S,3S,4R)-1-(alpha-D-galactopyranosyloxy)-3,4-dihydroxy-16-phenylhexadecan-2-yl]octanamide'>7LM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tw2\|5tw2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tw2\|5tw2]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5tw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tw5 OCA], [http://pdbe.org/5tw5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tw5 RCSB], [http://www.ebi.ac.uk/pdbsum/5tw5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tw5 ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cd1d1, Cd1.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5tw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tw5 OCA], [http://pdbe.org/5tw5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tw5 RCSB], [http://www.ebi.ac.uk/pdbsum/5tw5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tw5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5tw5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5tw5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Wang, J]]		[[Category: Wang, J]]
	[[Category: Zajonc, D M]]		[[Category: Zajonc, D M]]

OCA at 04:33, 21 September 2017

OCA — Thu, 21 Sep 2017 04:33:43 GMT

←Older revision		Revision as of 04:33, 21 September 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5tw5 is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Structure of mouse CD1d with bound glycosphingolipid JJ112==
		+	<StructureSection load='5tw5' size='340' side='right' caption='[[5tw5]], [[Resolution\|resolution]] 1.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5tw5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TW5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TW5 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7LM:N-[(2S,3S,4R)-1-(alpha-D-galactopyranosyloxy)-3,4-dihydroxy-16-phenylhexadecan-2-yl]octanamide'>7LM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tw2\|5tw2]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tw5 OCA], [http://pdbe.org/5tw5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tw5 RCSB], [http://www.ebi.ac.uk/pdbsum/5tw5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tw5 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CD1D1_MOUSE CD1D1_MOUSE]] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:11754812</ref> <ref>PMID:16314439</ref> <ref>PMID:16007091</ref> [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic alpha-galactosylceramide, they produce a vast amount of cytokines. Here we present a synthesis that allows swift modification of the phytosphingosine side chain by amidation of an advanced methyl ester precursor. The resulting KRN7000 derivatives, termed alpha-galactosylsphingamides, were evaluated for their capacity to stimulate iNKT-cells. While introduction of the amide-motif in the phytosphingosine chain is tolerated for CD1d binding and TCR recognition, the studied alpha-galactosylsphingamides showed compromised antigenic properties.

-	~~Authors~~: ~~Zajonc, D.M~~., Wang, J.	+	Galactosylsphingamides: new alpha-GalCer analogues to probe the F'-pocket of CD1d.,Guillaume J, Wang J, Janssens J, Remesh SG, Risseeuw MDP, Decruy T, Froeyen M, Elewaut D, Zajonc DM, Calenbergh SV Sci Rep. 2017 Jun 27;7(1):4276. doi: 10.1038/s41598-017-04461-7. PMID:28655912<ref>PMID:28655912</ref>

-	~~Description: Structure~~ of ~~mouse CD1d with bound glycosphingolipid JJ112~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Zajonc, D.M]]~~	+	<div class="pdbe-citations 5tw5" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Wang, J]]		[[Category: Wang, J]]
		+	[[Category: Zajonc, D M]]
		+	[[Category: Antigen-presentation]]
		+	[[Category: Glycolipid]]
		+	[[Category: Immune system-inhibitor complex]]
		+	[[Category: Mhc fold]]
		+	[[Category: T cell]]

OCA at 13:49, 9 March 2017

OCA — Thu, 09 Mar 2017 13:49:57 GMT

←Older revision		Revision as of 13:49, 9 March 2017
Line 7:		Line 7:
	Description: Structure of mouse CD1d with bound glycosphingolipid JJ112		Description: Structure of mouse CD1d with bound glycosphingolipid JJ112
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Wang, J]]
	[[Category: Zajonc, D.M]]		[[Category: Zajonc, D.M]]
		+	[[Category: Wang, J]]

OCA: Protected "5tw5" [edit=sysop:move=sysop]

OCA — Fri, 09 Dec 2016 17:57:57 GMT

Protected "5tw5" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:57, 9 December 2016

OCA: New page: '''Unreleased structure''' The entry 5tw5 is ON HOLD until Paper Publication Authors: Zajonc, D.M., Wang, J. Description: Structure of mouse CD1d with bound glycosphingolipid JJ112 [[C...

OCA — Fri, 09 Dec 2016 17:57:56 GMT

New page: '''Unreleased structure''' The entry 5tw5 is ON HOLD until Paper Publication Authors: Zajonc, D.M., Wang, J. Description: Structure of mouse CD1d with bound glycosphingolipid JJ112 [[C...

New page

'''Unreleased structure'''

The entry 5tw5 is ON HOLD until Paper Publication

Authors: Zajonc, D.M., Wang, J.

Description: Structure of mouse CD1d with bound glycosphingolipid JJ112
[[Category: Unreleased Structures]]
[[Category: Wang, J]]
[[Category: Zajonc, D.M]]