5tzn - Revision history

OCA at 13:17, 4 October 2023

OCA — Wed, 04 Oct 2023 13:17:06 GMT

←Older revision		Revision as of 13:17, 4 October 2023
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	<StructureSection load='5tzn' size='340' side='right'caption='[[5tzn]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5tzn' size='340' side='right'caption='[[5tzn]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tzn]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~] and [~~http~~://en.wikipedia.org/wiki/~~Muhv1 Muhv1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TZN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5TZN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tzn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Murid_betaherpesvirus_1 Murid betaherpesvirus 1] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TZN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Klrb1b, Klrb1d, Ly55d, Nkrp1b, Nkrp1d ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), m12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10366 MUHV1])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5tzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tzn OCA], [~~http~~://pdbe.org/5tzn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5tzn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5tzn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5tzn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tzn OCA], [https://pdbe.org/5tzn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tzn RCSB], [https://www.ebi.ac.uk/pdbsum/5tzn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tzn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KRBBB_MOUSE KRBBB_MOUSE]] Receptor for CLEC2D/OCIL. Ligand-binding contributes to inhibition of cytotoxic natural killer (NK) cells. May mediate MHC class I-independent "missing-self" recognition of allografts, tumor cells and virus-infected cells.<ref>PMID:12858173</ref> <ref>PMID:14990792</ref>	+	[https://www.uniprot.org/uniprot/KRBBB_MOUSE KRBBB_MOUSE] Receptor for CLEC2D/OCIL. Ligand-binding contributes to inhibition of cytotoxic natural killer (NK) cells. May mediate MHC class I-independent "missing-self" recognition of allografts, tumor cells and virus-infected cells.<ref>PMID:12858173</ref> <ref>PMID:14990792</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Murid betaherpesvirus 1]]
-	[[Category: ~~Muhv1~~]]	+	[[Category: Mus musculus]]
-	[[Category: Berry, R]]	+	[[Category: Berry R]]
-	[[Category: Rossjohn, J]]	+	[[Category: Rossjohn J]]
-	~~[[Category: C-type lectin-like domain]]~~	+
-	~~[[Category: Cell invasion]]~~	+
-	~~[[Category: Immonoglobulin like domain]]~~	+
-	~~[[Category: Immune system-viral protein complex~~]]	+

OCA at 08:20, 8 January 2020

OCA — Wed, 08 Jan 2020 08:20:23 GMT

←Older revision		Revision as of 08:20, 8 January 2020
Line 1:		Line 1:

	==Structure of the viral immunoevasin m12 (Smith) bound to the natural killer cell receptor NKR-P1B (B6)==		==Structure of the viral immunoevasin m12 (Smith) bound to the natural killer cell receptor NKR-P1B (B6)==
-	<StructureSection load='5tzn' size='340' side='right' caption='[[5tzn]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='5tzn' size='340' side='right'caption='[[5tzn]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tzn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TZN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tzn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [http://en.wikipedia.org/wiki/Muhv1 Muhv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TZN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Klrb1b, Klrb1d, Ly55d, Nkrp1b, Nkrp1d ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), m12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10366 MUHV1])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tzn OCA], [http://pdbe.org/5tzn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tzn RCSB], [http://www.ebi.ac.uk/pdbsum/5tzn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tzn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tzn OCA], [http://pdbe.org/5tzn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tzn RCSB], [http://www.ebi.ac.uk/pdbsum/5tzn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tzn ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
		+	[[Category: Muhv1]]
	[[Category: Berry, R]]		[[Category: Berry, R]]
	[[Category: Rossjohn, J]]		[[Category: Rossjohn, J]]

OCA at 13:37, 24 May 2017

OCA — Wed, 24 May 2017 13:37:34 GMT

←Older revision		Revision as of 13:37, 24 May 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5tzn is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Structure of the viral immunoevasin m12 (Smith) bound to the natural killer cell receptor NKR-P1B (B6)==
		+	<StructureSection load='5tzn' size='340' side='right' caption='[[5tzn]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5tzn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TZN FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tzn OCA], [http://pdbe.org/5tzn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tzn RCSB], [http://www.ebi.ac.uk/pdbsum/5tzn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tzn ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KRBBB_MOUSE KRBBB_MOUSE]] Receptor for CLEC2D/OCIL. Ligand-binding contributes to inhibition of cytotoxic natural killer (NK) cells. May mediate MHC class I-independent "missing-self" recognition of allografts, tumor cells and virus-infected cells.<ref>PMID:12858173</ref> <ref>PMID:14990792</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Natural killer (NK) cells play a key role in innate immunity by detecting alterations in self and non-self ligands via paired NK cell receptors (NKRs). Despite identification of numerous NKR-ligand interactions, physiological ligands for the prototypical NK1.1 orphan receptor remain elusive. Here, we identify a viral ligand for the inhibitory and activating NKR-P1 (NK1.1) receptors. This murine cytomegalovirus (MCMV)-encoded protein, m12, restrains NK cell effector function by directly engaging the inhibitory NKR-P1B receptor. However, m12 also interacts with the activating NKR-P1A/C receptors to counterbalance m12 decoy function. Structural analyses reveal that m12 sequesters a large NKR-P1 surface area via a "polar claw" mechanism. Polymorphisms in, and ablation of, the viral m12 protein and host NKR-P1B/C alleles impact NK cell responses in vivo. Thus, we identify the long-sought foreign ligand for this key immunoregulatory NKR family and reveal how it controls the evolutionary balance of immune recognition during host-pathogen interplay.

-	~~Authors~~:	+	A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.,Aguilar OA, Berry R, Rahim MM, Reichel JJ, Popovic B, Tanaka M, Fu Z, Balaji GR, Lau TN, Tu MM, Kirkham CL, Mahmoud AB, Mesci A, Krmpotic A, Allan DS, Makrigiannis AP, Jonjic S, Rossjohn J, Carlyle JR Cell. 2017 Mar 23;169(1):58-71.e14. doi: 10.1016/j.cell.2017.03.002. PMID:28340350<ref>PMID:28340350</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5tzn" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Berry, R]]
		+	[[Category: Rossjohn, J]]
		+	[[Category: C-type lectin-like domain]]
		+	[[Category: Cell invasion]]
		+	[[Category: Immonoglobulin like domain]]
		+	[[Category: Immune system-viral protein complex]]

OCA at 20:14, 22 December 2016

OCA — Thu, 22 Dec 2016 20:14:34 GMT

←Older revision		Revision as of 20:14, 22 December 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5tzn is ON HOLD	+	The entry 5tzn is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5tzn" [edit=sysop:move=sysop]

OCA — Fri, 09 Dec 2016 18:07:08 GMT

Protected "5tzn" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:07, 9 December 2016

OCA: New page: '''Unreleased structure''' The entry 5tzn is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Fri, 09 Dec 2016 18:07:07 GMT

New page: '''Unreleased structure''' The entry 5tzn is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5tzn is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]