5u26 - Revision history

OCA at 13:18, 4 October 2023

OCA — Wed, 04 Oct 2023 13:18:38 GMT

←Older revision		Revision as of 13:18, 4 October 2023
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	==Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p218 Inhibitor==		==Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p218 Inhibitor==
-	<StructureSection load='5u26' size='340' side='right' caption='[[5u26]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='5u26' size='340' side='right'caption='[[5u26]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5u26]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus~~ tuberculosis~~" (zopf 1883) klein 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U26 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5U26 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5u26]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5U26 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MMV:3-(2-{3-[(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)OXY]PROPOXY}PHENYL)PROPANOIC+ACID'>MMV</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">folA, folA_1, BN1213_03327, BN1303_00864, ERS007661_02580, ERS007663_03946, ERS007665_02766, ERS007741_00337, ERS013471_00736, ERS023446_01268, ERS024213_02711, ERS027644_04978, ERS027646_03318, ERS027653_04780, ERS027654_00299, ERS027656_00246, ERS027659_04151, ERS027661_03595, ERS027666_04095, ERS031537_04020, ERS124361_01473, RN05_2938 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MMV:3-(2-{3-[(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)OXY]PROPOXY}PHENYL)PROPANOIC+ACID'>MMV</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5u26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u26 OCA], [https://pdbe.org/5u26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5u26 RCSB], [https://www.ebi.ac.uk/pdbsum/5u26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5u26 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5u26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u26 OCA], [~~http~~://pdbe.org/5u26 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5u26 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5u26 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5u26 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~A0A0E8UVJ4_MYCTX A0A0E8UVJ4_MYCTX]~~] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[~~PIRNR:PIRNR000194~~]	+	[https://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
		+
		+	==See Also==
		+	*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dihydrofolate reductase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Structural genomic]]~~	+	[[Category: Mycobacterium tuberculosis]]
-	~~[[Category: Dhfr]]~~	+
-	~~[[Category: Folate]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Ssgcid~~]]	+

OCA at 10:20, 22 November 2017

OCA — Wed, 22 Nov 2017 10:20:01 GMT

←Older revision		Revision as of 10:20, 22 November 2017
Line 3:		Line 3:
	<StructureSection load='5u26' size='340' side='right' caption='[[5u26]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='5u26' size='340' side='right' caption='[[5u26]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5u26]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U26 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5u26]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U26 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MMV:3-(2-{3-[(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)OXY]PROPOXY}PHENYL)PROPANOIC+ACID'>MMV</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MMV:3-(2-{3-[(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)OXY]PROPOXY}PHENYL)PROPANOIC+ACID'>MMV</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">folA, folA_1, BN1213_03327, BN1303_00864, ERS007661_02580, ERS007663_03946, ERS007665_02766, ERS007741_00337, ERS013471_00736, ERS023446_01268, ERS024213_02711, ERS027644_04978, ERS027646_03318, ERS027653_04780, ERS027654_00299, ERS027656_00246, ERS027659_04151, ERS027661_03595, ERS027666_04095, ERS031537_04020, ERS124361_01473, RN05_2938 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u26 OCA], [http://pdbe.org/5u26 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u26 RCSB], [http://www.ebi.ac.uk/pdbsum/5u26 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u26 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u26 OCA], [http://pdbe.org/5u26 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u26 RCSB], [http://www.ebi.ac.uk/pdbsum/5u26 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u26 ProSAT]</span></td></tr>

OCA at 21:47, 22 December 2016

OCA — Thu, 22 Dec 2016 21:47:40 GMT

←Older revision		Revision as of 21:47, 22 December 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 5u26 is ON HOLD~~	+	==Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p218 Inhibitor==
-		+	<StructureSection load='5u26' size='340' side='right' caption='[[5u26]], [[Resolution\|resolution]] 1.85Å' scene=''>
-	~~Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5u26]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U26 FirstGlance]. <br>
-	~~Description:~~ Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p218 Inhibitor	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MMV:3-(2-{3-[(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)OXY]PROPOXY}PHENYL)PROPANOIC+ACID'>MMV</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
-	[[Category: ~~Seattle~~ Structural ~~Genomics Center For Infectious Disease (~~Ssgcid)]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u26 OCA], [http://pdbe.org/5u26 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u26 RCSB], [http://www.ebi.ac.uk/pdbsum/5u26 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u26 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/A0A0E8UVJ4_MYCTX A0A0E8UVJ4_MYCTX]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[PIRNR:PIRNR000194]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Dihydrofolate reductase]]
		+	[[Category: Structural genomic]]
		+	[[Category: Dhfr]]
		+	[[Category: Folate]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Ssgcid]]

OCA at 17:34, 15 December 2016

OCA — Thu, 15 Dec 2016 17:34:18 GMT

←Older revision		Revision as of 17:34, 15 December 2016
Line 3:		Line 3:
	The entry 5u26 is ON HOLD		The entry 5u26 is ON HOLD

-	Authors: ~~SSGCID,~~ Seattle Structural Genomics Center for Infectious Disease (SSGCID)	+	Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

	Description: Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p218 Inhibitor		Description: Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p218 Inhibitor
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Ssgcid,~~ Seattle Structural Genomics Center For Infectious Disease (Ssgcid)]]	+	[[Category: Seattle Structural Genomics Center For Infectious Disease (Ssgcid)]]

OCA: Protected "5u26" [edit=sysop:move=sysop]

OCA — Fri, 09 Dec 2016 18:12:29 GMT

Protected "5u26" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:12, 9 December 2016

OCA: New page: '''Unreleased structure''' The entry 5u26 is ON HOLD Authors: SSGCID, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: Crystal Structure of Mycobacterium...

OCA — Fri, 09 Dec 2016 18:12:28 GMT

New page: '''Unreleased structure''' The entry 5u26 is ON HOLD Authors: SSGCID, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: Crystal Structure of Mycobacterium...

New page

'''Unreleased structure'''

The entry 5u26 is ON HOLD

Authors: SSGCID, Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Description: Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p218 Inhibitor
[[Category: Unreleased Structures]]
[[Category: Ssgcid, Seattle Structural Genomics Center For Infectious Disease (Ssgcid)]]