5u3j - Revision history

OCA at 13:19, 4 October 2023

OCA — Wed, 04 Oct 2023 13:19:12 GMT

←Older revision		Revision as of 13:19, 4 October 2023
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	<StructureSection load='5u3j' size='340' side='right'caption='[[5u3j]], [[Resolution\|resolution]] 2.74Å' scene=''>		<StructureSection load='5u3j' size='340' side='right'caption='[[5u3j]], [[Resolution\|resolution]] 2.74Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5u3j]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human ~~Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U3J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5U3J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5u3j]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5U3J FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5u3k\|5u3k]], [[5u3l\|5u3l]], [[5u3m\|5u3m]], [[5u3n\|5u3n]], [[5u3o\|5u3o]], [[5u3p\|5u3p]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.74Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">IgG Heavy Chain ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN]), IgG Light Chain ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5u3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u3j OCA], [https://pdbe.org/5u3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5u3j RCSB], [https://www.ebi.ac.uk/pdbsum/5u3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5u3j ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5u3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u3j OCA], [~~http~~://pdbe.org/5u3j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5u3j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5u3j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5u3j ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/V9QIE5_9HIV1 V9QIE5_9HIV1]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]	+	[[Category: Homo sapiens]]
		+	[[Category: Human immunodeficiency virus 1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Haynes~~, B F~~]]	+	[[Category: Haynes BF]]
-	[[Category: Lougheed~~, C S~~]]	+	[[Category: Lougheed CS]]
-	[[Category: Nicely~~, N I~~]]	+	[[Category: Nicely NI]]
-	[[Category: Ofek, G]]	+	[[Category: Ofek G]]
-	[[Category: Williams~~, L D~~]]	+	[[Category: Williams LD]]
-	[[Category: Wu, L]]	+	[[Category: Wu L]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Gp41]]~~	+
-	~~[[Category: Hiv-1]]~~	+
-	~~[[Category: Immune system-viral protein complex]]~~	+
-	~~[[Category: Mper]]~~	+
-	~~[[Category: Neutralizing~~]]	+

OCA at 17:02, 11 December 2019

OCA — Wed, 11 Dec 2019 17:02:13 GMT

←Older revision		Revision as of 17:02, 11 December 2019
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	==Crystal Structure of DH511.1 Fab in Complex with HIV-1 gp41 MPER Peptide==		==Crystal Structure of DH511.1 Fab in Complex with HIV-1 gp41 MPER Peptide==
-	<StructureSection load='5u3j' size='340' side='right' caption='[[5u3j]], [[Resolution\|resolution]] 2.74Å' scene=''>	+	<StructureSection load='5u3j' size='340' side='right'caption='[[5u3j]], [[Resolution\|resolution]] 2.74Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5u3j]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U3J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U3J FirstGlance]. <br>		<table><tr><td colspan='2'>[[5u3j]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U3J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U3J FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Haynes, B F]]		[[Category: Haynes, B F]]
	[[Category: Lougheed, C S]]		[[Category: Lougheed, C S]]

OCA at 10:20, 22 November 2017

OCA — Wed, 22 Nov 2017 10:20:32 GMT

←Older revision		Revision as of 10:20, 22 November 2017
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	<StructureSection load='5u3j' size='340' side='right' caption='[[5u3j]], [[Resolution\|resolution]] 2.74Å' scene=''>		<StructureSection load='5u3j' size='340' side='right' caption='[[5u3j]], [[Resolution\|resolution]] 2.74Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5u3j]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U3J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U3J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5u3j]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U3J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U3J FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[~~d_1000225288~~\|~~d_1000225288~~]], [[~~d_1000225282~~\|~~d_1000225282~~]], [[~~d_1000225285~~\|~~d_1000225285~~]], [[~~d_1000225286~~\|~~d_1000225286~~]], [[~~d_1000225287~~\|~~d_1000225287~~]], [[~~d_1000225289~~\|~~d_1000225289~~]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5u3k\|5u3k]], [[5u3l\|5u3l]], [[5u3m\|5u3m]], [[5u3n\|5u3n]], [[5u3o\|5u3o]], [[5u3p\|5u3p]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IgG Heavy Chain ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IgG Light Chain ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u3j OCA], [http://pdbe.org/5u3j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u3j RCSB], [http://www.ebi.ac.uk/pdbsum/5u3j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u3j ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u3j OCA], [http://pdbe.org/5u3j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u3j RCSB], [http://www.ebi.ac.uk/pdbsum/5u3j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u3j ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Haynes, B F]]		[[Category: Haynes, B F]]
	[[Category: Lougheed, C S]]		[[Category: Lougheed, C S]]

OCA at 11:11, 24 August 2017

OCA — Thu, 24 Aug 2017 11:11:24 GMT

←Older revision		Revision as of 11:11, 24 August 2017
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u3j OCA], [http://pdbe.org/5u3j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u3j RCSB], [http://www.ebi.ac.uk/pdbsum/5u3j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u3j ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u3j OCA], [http://pdbe.org/5u3j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u3j RCSB], [http://www.ebi.ac.uk/pdbsum/5u3j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u3j ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. Antibody 10E8, reactive with the distal portion of the membrane-proximal external region (MPER) of HIV-1 gp41, is broadly neutralizing. However, the ontogeny of distal MPER antibodies and the relationship of memory B cell to plasma bnAbs are poorly understood. HIV-1-specific memory B cell flow sorting and proteomic identification of anti-MPER plasma antibodies from an HIV-1-infected individual were used to isolate broadly neutralizing distal MPER bnAbs of the same B cell clonal lineage. Structural analysis demonstrated that antibodies from memory B cells and plasma recognized the envelope gp41 bnAb epitope in a distinct orientation compared with other distal MPER bnAbs. The unmutated common ancestor of this distal MPER bnAb was autoreactive, suggesting lineage immune tolerance control. Construction of chimeric antibodies of memory B cell and plasma antibodies yielded a bnAb that potently neutralized most HIV-1 strains.
		+
		+	Potent and broad HIV-neutralizing antibodies in memory B cells and plasma.,Williams LD, Ofek G, Schatzle S, McDaniel JR, Lu X, Nicely NI, Wu L, Lougheed CS, Bradley T, Louder MK, McKee K, Bailer RT, O'Dell S, Georgiev IS, Seaman MS, Parks RJ, Marshall DJ, Anasti K, Yang G, Nie X, Tumba NL, Wiehe K, Wagh K, Korber B, Kepler TB, Munir Alam S, Morris L, Kamanga G, Cohen MS, Bonsignori M, Xia SM, Montefiori DC, Kelsoe G, Gao F, Mascola JR, Moody MA, Saunders KO, Liao HX, Tomaras GD, Georgiou G, Haynes BF Sci Immunol. 2017 Jan 27;2(7). pii: eaal2200. doi: 10.1126/sciimmunol.aal2200. PMID:28783671<ref>PMID:28783671</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5u3j" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:45, 10 March 2017

OCA — Fri, 10 Mar 2017 17:45:58 GMT

←Older revision		Revision as of 17:45, 10 March 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5u3j ~~is ON HOLD~~	+	==Crystal Structure of DH511.1 Fab in Complex with HIV-1 gp41 MPER Peptide==
-		+	<StructureSection load='5u3j' size='340' side='right' caption='[[5u3j]], [[Resolution\|resolution]] 2.74Å' scene=''>
-	~~Authors~~: ~~Ofek, G~~., Wu, L., ~~Lougheed~~, C.S., ~~Williams, L~~.D., ~~Nicely~~, N.I., Haynes, B.F.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5u3j]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U3J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U3J FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure of DH511.1 Fab in Complex with HIV-1 gp41 MPER Peptide~~	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[d_1000225288\|d_1000225288]], [[d_1000225282\|d_1000225282]], [[d_1000225285\|d_1000225285]], [[d_1000225286\|d_1000225286]], [[d_1000225287\|d_1000225287]], [[d_1000225289\|d_1000225289]]</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u3j OCA], [http://pdbe.org/5u3j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u3j RCSB], [http://www.ebi.ac.uk/pdbsum/5u3j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u3j ProSAT]</span></td></tr>
-	[[Category: ~~Haynes~~, ~~B.F~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Haynes, B F]]
		+	[[Category: Lougheed, C S]]
		+	[[Category: Nicely, N I]]
		+	[[Category: Ofek, G]]
		+	[[Category: Williams, L D]]
	[[Category: Wu, L]]		[[Category: Wu, L]]
-	[[Category: ~~Ofek, G~~]]	+	[[Category: Antibody]]
-	[[Category: ~~Lougheed, C.S~~]]	+	[[Category: Gp41]]
-	[[Category: ~~Williams, L.D~~]]	+	[[Category: Hiv-1]]
-	[[Category: ~~Nicely, N.I~~]]	+	[[Category: Immune system-viral protein complex]]
		+	[[Category: Mper]]
		+	[[Category: Neutralizing]]

OCA: Protected "5u3j" [edit=sysop:move=sysop]

OCA — Thu, 15 Dec 2016 17:37:25 GMT

Protected "5u3j" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:37, 15 December 2016

OCA: New page: '''Unreleased structure''' The entry 5u3j is ON HOLD Authors: Ofek, G., Wu, L., Lougheed, C.S., Williams, L.D., Nicely, N.I., Haynes, B.F. Description: Crystal Structure of DH511.1 Fab...

OCA — Thu, 15 Dec 2016 17:37:23 GMT

New page: '''Unreleased structure''' The entry 5u3j is ON HOLD Authors: Ofek, G., Wu, L., Lougheed, C.S., Williams, L.D., Nicely, N.I., Haynes, B.F. Description: Crystal Structure of DH511.1 Fab...

New page

'''Unreleased structure'''

The entry 5u3j is ON HOLD

Authors: Ofek, G., Wu, L., Lougheed, C.S., Williams, L.D., Nicely, N.I., Haynes, B.F.

Description: Crystal Structure of DH511.1 Fab in Complex with HIV-1 gp41 MPER Peptide
[[Category: Unreleased Structures]]
[[Category: Haynes, B.F]]
[[Category: Wu, L]]
[[Category: Ofek, G]]
[[Category: Lougheed, C.S]]
[[Category: Williams, L.D]]
[[Category: Nicely, N.I]]