5u3p - Revision history

OCA at 13:19, 4 October 2023

OCA — Wed, 04 Oct 2023 13:19:24 GMT

←Older revision		Revision as of 13:19, 4 October 2023
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	<StructureSection load='5u3p' size='340' side='right'caption='[[5u3p]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='5u3p' size='340' side='right'caption='[[5u3p]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5u3p]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U3P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5U3P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5u3p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5U3P FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5u3j\|5u3j]]~~, [[~~5u3k~~\|~~5u3k]], [[5u3l\|5u3l]], [[5u3m\|5u3m]], [[5u3n\|5u3n]], [[5u3o\|5u3o~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5u3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u3p OCA], [~~http~~://pdbe.org/5u3p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5u3p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5u3p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5u3p ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5u3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u3p OCA], [https://pdbe.org/5u3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5u3p RCSB], [https://www.ebi.ac.uk/pdbsum/5u3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5u3p ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Haynes~~, B F~~]]	+	[[Category: Haynes BF]]
-	[[Category: Nicely~~, N I~~]]	+	[[Category: Nicely NI]]
-	[[Category: Ofek, G]]	+	[[Category: Ofek G]]
-	[[Category: Williams~~, L D]]~~	+	[[Category: Williams LD]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Gp41]]~~	+
-	~~[[Category: Hiv-1]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Mper]]~~	+
-	~~[[Category: Neutralizing~~]]	+

OCA at 17:02, 11 December 2019

OCA — Wed, 11 Dec 2019 17:02:46 GMT

←Older revision		Revision as of 17:02, 11 December 2019
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	==Crystal Structure of DH511.4 Fab==		==Crystal Structure of DH511.4 Fab==
-	<StructureSection load='5u3p' size='340' side='right' caption='[[5u3p]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='5u3p' size='340' side='right'caption='[[5u3p]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5u3p]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U3P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U3P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5u3p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U3P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U3P FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5u3j\|5u3j]], [[5u3k\|5u3k]], [[5u3l\|5u3l]], [[5u3m\|5u3m]], [[5u3n\|5u3n]], [[5u3o\|5u3o]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5u3j\|5u3j]], [[5u3k\|5u3k]], [[5u3l\|5u3l]], [[5u3m\|5u3m]], [[5u3n\|5u3n]], [[5u3o\|5u3o]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u3p OCA], [http://pdbe.org/5u3p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u3p RCSB], [http://www.ebi.ac.uk/pdbsum/5u3p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u3p ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u3p OCA], [http://pdbe.org/5u3p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u3p RCSB], [http://www.ebi.ac.uk/pdbsum/5u3p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u3p ProSAT]</span></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Haynes, B F]]		[[Category: Haynes, B F]]
	[[Category: Nicely, N I]]		[[Category: Nicely, N I]]

OCA at 11:00, 24 August 2017

OCA — Thu, 24 Aug 2017 11:00:17 GMT

←Older revision		Revision as of 11:00, 24 August 2017
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u3p OCA], [http://pdbe.org/5u3p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u3p RCSB], [http://www.ebi.ac.uk/pdbsum/5u3p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u3p ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u3p OCA], [http://pdbe.org/5u3p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u3p RCSB], [http://www.ebi.ac.uk/pdbsum/5u3p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u3p ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. Antibody 10E8, reactive with the distal portion of the membrane-proximal external region (MPER) of HIV-1 gp41, is broadly neutralizing. However, the ontogeny of distal MPER antibodies and the relationship of memory B cell to plasma bnAbs are poorly understood. HIV-1-specific memory B cell flow sorting and proteomic identification of anti-MPER plasma antibodies from an HIV-1-infected individual were used to isolate broadly neutralizing distal MPER bnAbs of the same B cell clonal lineage. Structural analysis demonstrated that antibodies from memory B cells and plasma recognized the envelope gp41 bnAb epitope in a distinct orientation compared with other distal MPER bnAbs. The unmutated common ancestor of this distal MPER bnAb was autoreactive, suggesting lineage immune tolerance control. Construction of chimeric antibodies of memory B cell and plasma antibodies yielded a bnAb that potently neutralized most HIV-1 strains.
		+
		+	Potent and broad HIV-neutralizing antibodies in memory B cells and plasma.,Williams LD, Ofek G, Schatzle S, McDaniel JR, Lu X, Nicely NI, Wu L, Lougheed CS, Bradley T, Louder MK, McKee K, Bailer RT, O'Dell S, Georgiev IS, Seaman MS, Parks RJ, Marshall DJ, Anasti K, Yang G, Nie X, Tumba NL, Wiehe K, Wagh K, Korber B, Kepler TB, Munir Alam S, Morris L, Kamanga G, Cohen MS, Bonsignori M, Xia SM, Montefiori DC, Kelsoe G, Gao F, Mascola JR, Moody MA, Saunders KO, Liao HX, Tomaras GD, Georgiou G, Haynes BF Sci Immunol. 2017 Jan 27;2(7). pii: eaal2200. doi: 10.1126/sciimmunol.aal2200. PMID:28783671<ref>PMID:28783671</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5u3p" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:46, 10 March 2017

OCA — Fri, 10 Mar 2017 17:46:18 GMT

←Older revision		Revision as of 17:46, 10 March 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5u3p ~~is ON HOLD until Paper Publication~~	+	==Crystal Structure of DH511.4 Fab==
-		+	<StructureSection load='5u3p' size='340' side='right' caption='[[5u3p]], [[Resolution\|resolution]] 1.50Å' scene=''>
-	~~Authors~~: ~~Nicely, N~~.I., ~~Williams~~, L.D., ~~Ofek~~, G., ~~Haynes~~, B.F.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5u3p]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U3P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U3P FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure of DH511~~.~~4 Fab~~	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5u3j\|5u3j]], [[5u3k\|5u3k]], [[5u3l\|5u3l]], [[5u3m\|5u3m]], [[5u3n\|5u3n]], [[5u3o\|5u3o]]</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u3p OCA], [http://pdbe.org/5u3p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u3p RCSB], [http://www.ebi.ac.uk/pdbsum/5u3p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u3p ProSAT]</span></td></tr>
-	[[Category: ~~Haynes~~, ~~B.F~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Haynes, B F]]
		+	[[Category: Nicely, N I]]
	[[Category: Ofek, G]]		[[Category: Ofek, G]]
-	[[Category: Williams, L.D]]	+	[[Category: Williams, L D]]
-	[[Category: ~~Nicely, N.I~~]]	+	[[Category: Antibody]]
		+	[[Category: Gp41]]
		+	[[Category: Hiv-1]]
		+	[[Category: Immune system]]
		+	[[Category: Mper]]
		+	[[Category: Neutralizing]]

OCA at 21:34, 25 January 2017

OCA — Wed, 25 Jan 2017 21:34:34 GMT

←Older revision		Revision as of 21:34, 25 January 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5u3p is ON HOLD	+	The entry 5u3p is ON HOLD until Paper Publication

	Authors: Nicely, N.I., Williams, L.D., Ofek, G., Haynes, B.F.		Authors: Nicely, N.I., Williams, L.D., Ofek, G., Haynes, B.F.

OCA: Protected "5u3p" [edit=sysop:move=sysop]

OCA — Thu, 15 Dec 2016 17:37:49 GMT

Protected "5u3p" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:37, 15 December 2016

OCA: New page: '''Unreleased structure''' The entry 5u3p is ON HOLD Authors: Nicely, N.I., Williams, L.D., Ofek, G., Haynes, B.F. Description: Crystal Structure of DH511.4 Fab [[Category: Unreleased ...

OCA — Thu, 15 Dec 2016 17:37:48 GMT

New page: '''Unreleased structure''' The entry 5u3p is ON HOLD Authors: Nicely, N.I., Williams, L.D., Ofek, G., Haynes, B.F. Description: Crystal Structure of DH511.4 Fab [[Category: Unreleased ...

New page

'''Unreleased structure'''

The entry 5u3p is ON HOLD

Authors: Nicely, N.I., Williams, L.D., Ofek, G., Haynes, B.F.

Description: Crystal Structure of DH511.4 Fab
[[Category: Unreleased Structures]]
[[Category: Haynes, B.F]]
[[Category: Ofek, G]]
[[Category: Williams, L.D]]
[[Category: Nicely, N.I]]