5u4v - Revision history

OCA at 13:20, 4 October 2023

OCA — Wed, 04 Oct 2023 13:20:52 GMT

←Older revision		Revision as of 13:20, 4 October 2023
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	<StructureSection load='5u4v' size='340' side='right'caption='[[5u4v]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5u4v' size='340' side='right'caption='[[5u4v]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5u4v]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U4V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5U4V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5u4v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5U4V FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5u4u\|5u4u]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">ARHGAP5, RHOGAP5 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5u4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u4v OCA], [https://pdbe.org/5u4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5u4v RCSB], [https://www.ebi.ac.uk/pdbsum/5u4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5u4v ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5u4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u4v OCA], [~~http~~://pdbe.org/5u4v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5u4v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5u4v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5u4v ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RHG05_HUMAN RHG05_HUMAN]] GTPase-activating protein for Rho family members. May play a role in the reduction of the p21rasGTPase-activating potential of RASA1/p120GAP.	+	[https://www.uniprot.org/uniprot/RHG05_HUMAN RHG05_HUMAN] GTPase-activating protein for Rho family members. May play a role in the reduction of the p21rasGTPase-activating potential of RASA1/p120GAP.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Boggon~~, T J~~]]	+	[[Category: Boggon TJ]]
-	[[Category: Stiegler~~, A L]]~~	+	[[Category: Stiegler AL]]
-	~~[[Category: Arhgap35]]~~	+
-	~~[[Category: Arhgap5]]~~	+
-	~~[[Category: G domain]]~~	+
-	~~[[Category: Gap]]~~	+
-	~~[[Category: Gtpase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Pseudogtpase]]~~	+
-	~~[[Category: Rho~~]]	+

OCA at 09:05, 18 December 2019

OCA — Wed, 18 Dec 2019 09:05:07 GMT

←Older revision		Revision as of 09:05, 18 December 2019
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	==pseudoGTPase domain (pG1) of p190RhoGAP-B==		==pseudoGTPase domain (pG1) of p190RhoGAP-B==
-	<StructureSection load='5u4v' size='340' side='right' caption='[[5u4v]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='5u4v' size='340' side='right'caption='[[5u4v]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5u4v]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U4V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5u4v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U4V FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5u4u\|5u4u]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5u4u\|5u4u]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ARHGAP5, RHOGAP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u4v OCA], [http://pdbe.org/5u4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u4v RCSB], [http://www.ebi.ac.uk/pdbsum/5u4v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u4v ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u4v OCA], [http://pdbe.org/5u4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u4v RCSB], [http://www.ebi.ac.uk/pdbsum/5u4v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u4v ProSAT]</span></td></tr>
	</table>		</table>
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	</div>		</div>
	<div class="pdbe-citations 5u4v" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5u4v" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Rho GTPase activating protein 3D structures\|Rho GTPase activating protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Boggon, T J]]		[[Category: Boggon, T J]]
	[[Category: Stiegler, A L]]		[[Category: Stiegler, A L]]

OCA at 10:09, 27 September 2017

OCA — Wed, 27 Sep 2017 10:09:31 GMT

←Older revision		Revision as of 10:09, 27 September 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5u4v is ~~ON HOLD until Paper~~ Publication	+	==pseudoGTPase domain (pG1) of p190RhoGAP-B==
		+	<StructureSection load='5u4v' size='340' side='right' caption='[[5u4v]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5u4v]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U4V FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5u4u\|5u4u]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u4v OCA], [http://pdbe.org/5u4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u4v RCSB], [http://www.ebi.ac.uk/pdbsum/5u4v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u4v ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RHG05_HUMAN RHG05_HUMAN]] GTPase-activating protein for Rho family members. May play a role in the reduction of the p21rasGTPase-activating potential of RASA1/p120GAP.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The two p190RhoGAP proteins, p190RhoGAP-A and -B, are key regulators of Rho GTPase signaling and are essential for actin cytoskeletal structure and contractility. Here we report the discovery of two evolutionarily conserved GTPase-like domains located in the 'middle domain', previously thought to be unstructured. Deletion of these domains reduces RhoGAP activity. Crystal structures, MANT-GTPgammaS binding, thermal denaturation, biochemical assays and sequence homology analysis all strongly support defects in nucleotide-binding activity. Analysis of p190RhoGAP proteins therefore indicates the presence of two previously unidentified domains which represent an emerging group of pseudoenzymes, the pseudoGTPases.A growing number of 'pseudoenzymes' with a regulatory role in signal transduction processes but without catalytic activity are being identified. Here, the authors identify two pseudoGTPase domains in p190RhoGAP, characterize them biochemically and structurally and show that they influence RhoGAP activity.

-	~~Authors~~:	+	p190RhoGAP proteins contain pseudoGTPase domains.,Stiegler AL, Boggon TJ Nat Commun. 2017 Sep 11;8(1):506. doi: 10.1038/s41467-017-00483-x. PMID:28894085<ref>PMID:28894085</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5u4v" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Boggon, T J]]
		+	[[Category: Stiegler, A L]]
		+	[[Category: Arhgap35]]
		+	[[Category: Arhgap5]]
		+	[[Category: G domain]]
		+	[[Category: Gap]]
		+	[[Category: Gtpase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Pseudogtpase]]
		+	[[Category: Rho]]

OCA at 20:23, 22 December 2016

OCA — Thu, 22 Dec 2016 20:23:49 GMT

←Older revision		Revision as of 20:23, 22 December 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5u4v is ON HOLD	+	The entry 5u4v is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5u4v" [edit=sysop:move=sysop]

OCA — Thu, 15 Dec 2016 17:40:35 GMT

Protected "5u4v" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:40, 15 December 2016

OCA: New page: '''Unreleased structure''' The entry 5u4v is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 15 Dec 2016 17:40:34 GMT

New page: '''Unreleased structure''' The entry 5u4v is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5u4v is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]