5u78 - Revision history

OCA at 13:22, 4 October 2023

OCA — Wed, 04 Oct 2023 13:22:18 GMT

←Older revision		Revision as of 13:22, 4 October 2023
Line 3:		Line 3:
	<StructureSection load='5u78' size='340' side='right'caption='[[5u78]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='5u78' size='340' side='right'caption='[[5u78]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5u78]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U78 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5U78 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5u78]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U78 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5U78 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5u77\|5u77]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.978Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">OSBPL8, KIAA1451, ORP8, OSBP10 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5u78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u78 OCA], [https://pdbe.org/5u78 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5u78 RCSB], [https://www.ebi.ac.uk/pdbsum/5u78 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5u78 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5u78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u78 OCA], [~~http~~://pdbe.org/5u78 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5u78 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5u78 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5u78 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/OSBL8_HUMAN OSBL8_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ghai, R]]	+	[[Category: Ghai R]]
-	[[Category: Yang, H]]	+	[[Category: Yang H]]
-	~~[[Category: Lipid transport]]~~	+
-	~~[[Category: Membrane contact site]]~~	+
-	~~[[Category: Oxsyterol]]~~	+
-	~~[[Category: Phosphoinositide~~]]	+

OCA at 09:12, 1 January 2020

OCA — Wed, 01 Jan 2020 09:12:14 GMT

←Older revision		Revision as of 09:12, 1 January 2020
Line 1:		Line 1:

	==Crystal structure of ORP8 PH domain in P1211 space group==		==Crystal structure of ORP8 PH domain in P1211 space group==
-	<StructureSection load='5u78' size='340' side='right' caption='[[5u78]], [[Resolution\|resolution]] 1.98Å' scene=''>	+	<StructureSection load='5u78' size='340' side='right'caption='[[5u78]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5u78]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U78 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U78 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5u78]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U78 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U78 FirstGlance]. <br>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ghai, R]]		[[Category: Ghai, R]]
	[[Category: Yang, H]]		[[Category: Yang, H]]

OCA at 08:13, 17 January 2018

OCA — Wed, 17 Jan 2018 08:13:19 GMT

←Older revision		Revision as of 08:13, 17 January 2018
Line 3:		Line 3:
	<StructureSection load='5u78' size='340' side='right' caption='[[5u78]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='5u78' size='340' side='right' caption='[[5u78]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5u78]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U78 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U78 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5u78]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U78 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U78 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5u77\|5u77]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5u77\|5u77]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OSBPL8, KIAA1451, ORP8, OSBP10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u78 OCA], [http://pdbe.org/5u78 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u78 RCSB], [http://www.ebi.ac.uk/pdbsum/5u78 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u78 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u78 OCA], [http://pdbe.org/5u78 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u78 RCSB], [http://www.ebi.ac.uk/pdbsum/5u78 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u78 ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Ghai, R]]		[[Category: Ghai, R]]
	[[Category: Yang, H]]		[[Category: Yang, H]]

OCA at 06:55, 18 October 2017

OCA — Wed, 18 Oct 2017 06:55:26 GMT

←Older revision		Revision as of 06:55, 18 October 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5u78 is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of ORP8 PH domain in P1211 space group==
		+	<StructureSection load='5u78' size='340' side='right' caption='[[5u78]], [[Resolution\|resolution]] 1.98Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5u78]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U78 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U78 FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5u77\|5u77]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u78 OCA], [http://pdbe.org/5u78 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u78 RCSB], [http://www.ebi.ac.uk/pdbsum/5u78 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u78 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ORP5 and ORP8, members of the oxysterol-binding protein (OSBP)-related proteins (ORP) family, are endoplasmic reticulum membrane proteins implicated in lipid trafficking. ORP5 and ORP8 are reported to localize to endoplasmic reticulum-plasma membrane junctions via binding to phosphatidylinositol-4-phosphate (PtdIns(4)P), and act as a PtdIns(4)P/phosphatidylserine counter exchanger between the endoplasmic reticulum and plasma membrane. Here we provide evidence that the pleckstrin homology domain of ORP5/8 via PtdIns(4,5)P 2, and not PtdIns(4)P binding mediates the recruitment of ORP5/8 to endoplasmic reticulum-plasma membrane contact sites. The OSBP-related domain of ORP8 can extract and transport multiple phosphoinositides in vitro, and knocking down both ORP5 and ORP8 in cells increases the plasma membrane level of PtdIns(4,5)P 2 with little effect on PtdIns(4)P. Overall, our data show, for the first time, that phosphoinositides other than PtdIns(4)P can also serve as co-exchangers for the transport of cargo lipids by ORPs.ORP5/8 are endoplasmic reticulum (ER) membrane proteins implicated in lipid trafficking that localize to ER-plasma membrane (PM) contacts and maintain membrane homeostasis. Here the authors show that PtdIns(4,5)P 2 plays a critical role in the targeting and function of ORP5/8 at the PM.

-	~~Authors: Ghai~~, R., ~~Yang~~, H.	+	ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane.,Ghai R, Du X, Wang H, Dong J, Ferguson C, Brown AJ, Parton RG, Wu JW, Yang H Nat Commun. 2017 Oct 2;8(1):757. doi: 10.1038/s41467-017-00861-5. PMID:28970484<ref>PMID:28970484</ref>

-	~~Description: Crystal structure~~ of ~~ORP8 PH domain in P1211 space group~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Yang, H]]~~	+	<div class="pdbe-citations 5u78" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Ghai, R]]		[[Category: Ghai, R]]
		+	[[Category: Yang, H]]
		+	[[Category: Lipid transport]]
		+	[[Category: Membrane contact site]]
		+	[[Category: Oxsyterol]]
		+	[[Category: Phosphoinositide]]

OCA at 13:33, 27 September 2017

OCA — Wed, 27 Sep 2017 13:33:56 GMT

←Older revision		Revision as of 13:33, 27 September 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5u78 is ON HOLD	+	The entry 5u78 is ON HOLD until Paper Publication

	Authors: Ghai, R., Yang, H.		Authors: Ghai, R., Yang, H.

-	Description: Crystal structure of ORP8 PH domain	+	Description: Crystal structure of ORP8 PH domain in P1211 space group
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Ghai, R]]
	[[Category: Yang, H]]		[[Category: Yang, H]]
		+	[[Category: Ghai, R]]

OCA at 08:54, 12 April 2017

OCA — Wed, 12 Apr 2017 08:54:02 GMT

←Older revision		Revision as of 08:54, 12 April 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5u78 is ON HOLD ~~until Paper Publication~~	+	The entry 5u78 is ON HOLD

	Authors: Ghai, R., Yang, H.		Authors: Ghai, R., Yang, H.

OCA at 18:48, 15 March 2017

OCA — Wed, 15 Mar 2017 18:48:48 GMT

←Older revision		Revision as of 18:48, 15 March 2017
Line 7:		Line 7:
	Description: Crystal structure of ORP8 PH domain		Description: Crystal structure of ORP8 PH domain
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Yang, H]]
	[[Category: Ghai, R]]		[[Category: Ghai, R]]
		+	[[Category: Yang, H]]

OCA at 14:13, 9 March 2017

OCA — Thu, 09 Mar 2017 14:13:56 GMT

←Older revision		Revision as of 14:13, 9 March 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5u78 is ON HOLD	+	The entry 5u78 is ON HOLD until Paper Publication

	Authors: Ghai, R., Yang, H.		Authors: Ghai, R., Yang, H.

OCA: Protected "5u78" [edit=sysop:move=sysop]

OCA — Thu, 22 Dec 2016 20:29:19 GMT

Protected "5u78" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:29, 22 December 2016

OCA: New page: '''Unreleased structure''' The entry 5u78 is ON HOLD Authors: Ghai, R., Yang, H. Description: Crystal structure of ORP8 PH domain Category: Unreleased Structures [[Category: Yang, ...

OCA — Thu, 22 Dec 2016 20:29:18 GMT

New page: '''Unreleased structure''' The entry 5u78 is ON HOLD Authors: Ghai, R., Yang, H. Description: Crystal structure of ORP8 PH domain Category: Unreleased Structures [[Category: Yang, ...

New page

'''Unreleased structure'''

The entry 5u78 is ON HOLD

Authors: Ghai, R., Yang, H.

Description: Crystal structure of ORP8 PH domain
[[Category: Unreleased Structures]]
[[Category: Yang, H]]
[[Category: Ghai, R]]