5u82 - Revision history

OCA at 10:05, 22 May 2024

OCA — Wed, 22 May 2024 10:05:29 GMT

←Older revision		Revision as of 10:05, 22 May 2024
Line 3:		Line 3:
	<StructureSection load='5u82' size='340' side='right'caption='[[5u82]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='5u82' size='340' side='right'caption='[[5u82]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5u82]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U82 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5U82 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5u82]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U82 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5U82 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>~~, ~~<scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=ZN0:TRIETHYLTIN+CHLORIDE'>ZN0</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.851Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3f0p\|3f0p]], [[5c0u\|5c0u]], [[5c17\|5c17]], [[5c0t\|5c0t]], [[5u79\|5u79]], [[5u7a\|5u7a]], [[5u7c\|5u7c]], [[5u7b\|5u7b]], [[5u83\|5u83]], [[5u88\|5u88]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=ZN0:TRIETHYLTIN+CHLORIDE'>ZN0</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>merB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~562~~ "~~Bacillus coli~~" ~~Migula 1895])~~<~~/td~~></tr>	+
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Alkylmercury_lyase Alkylmercury lyase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.99.1.2 4.99.1.2]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5u82 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u82 OCA], [https://pdbe.org/5u82 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5u82 RCSB], [https://www.ebi.ac.uk/pdbsum/5u82 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5u82 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5u82 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u82 OCA], [https://pdbe.org/5u82 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5u82 RCSB], [https://www.ebi.ac.uk/pdbsum/5u82 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5u82 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MERB_ECOLX MERB_ECOLX]] Cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. One product is Hg(2+), which is subsequently detoxified by the mercuric reductase (By similarity).	+	[https://www.uniprot.org/uniprot/MERB_ECOLX MERB_ECOLX] Cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. One product is Hg(2+), which is subsequently detoxified by the mercuric reductase (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus coli migula 1895]]
-	[[Category: Alkylmercury lyase]]
-	[[Category: Large Structures]]
-	[[Category: Mansour, A]]
-	[[Category: Omichinski, J G]]
-	[[Category: Stevenson, M]]
-	[[Category: Sygusch, J]]
-	[[Category: Wahba, H M]]
-	[[Category: Wilcox, D E]]
-	[[Category: Bacterial protein]]
-	[[Category: Cysteine]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: ~~Lyase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Mercury~~]]	+	[[Category: Mansour A]]
-	[[Category: ~~Metal binding protein~~]]	+	[[Category: Omichinski JG]]
-	[[Category: ~~Triethyltin~~]]	+	[[Category: Stevenson M]]
		+	[[Category: Sygusch J]]
		+	[[Category: Wahba HM]]
		+	[[Category: Wilcox DE]]

OCA at 11:42, 27 April 2022

OCA — Wed, 27 Apr 2022 11:42:16 GMT

OCA at 07:56, 27 November 2019

OCA — Wed, 27 Nov 2019 07:56:23 GMT

←Older revision		Revision as of 07:56, 27 November 2019
Line 1:		Line 1:

	==Crystal structure of a MerB-triethyltin complex==		==Crystal structure of a MerB-triethyltin complex==
-	<StructureSection load='5u82' size='340' side='right' caption='[[5u82]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='5u82' size='340' side='right'caption='[[5u82]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5u82]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U82 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U82 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5u82]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U82 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U82 FirstGlance]. <br>
Line 27:		Line 27:
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Alkylmercury lyase]]		[[Category: Alkylmercury lyase]]
		+	[[Category: Large Structures]]
	[[Category: Mansour, A]]		[[Category: Mansour, A]]
	[[Category: Omichinski, J G]]		[[Category: Omichinski, J G]]

OCA at 07:05, 28 March 2018

OCA — Wed, 28 Mar 2018 07:05:58 GMT

←Older revision		Revision as of 07:05, 28 March 2018
Line 3:		Line 3:
	<StructureSection load='5u82' size='340' side='right' caption='[[5u82]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='5u82' size='340' side='right' caption='[[5u82]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5u82]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U82 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U82 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5u82]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U82 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U82 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=ZN0:TRIETHYLTIN+CHLORIDE'>ZN0</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=ZN0:TRIETHYLTIN+CHLORIDE'>ZN0</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f0p\|3f0p]], [[5c0u\|5c0u]], [[5c17\|5c17]], [[5c0t\|5c0t]], [[5u79\|5u79]], [[5u7a\|5u7a]], [[5u7c\|5u7c]], [[5u7b\|5u7b]], [[5u83\|5u83]], [[5u88\|5u88]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f0p\|3f0p]], [[5c0u\|5c0u]], [[5c17\|5c17]], [[5c0t\|5c0t]], [[5u79\|5u79]], [[5u7a\|5u7a]], [[5u7c\|5u7c]], [[5u7b\|5u7b]], [[5u83\|5u83]], [[5u88\|5u88]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">merB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkylmercury_lyase Alkylmercury lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.99.1.2 4.99.1.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkylmercury_lyase Alkylmercury lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.99.1.2 4.99.1.2] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u82 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u82 OCA], [http://pdbe.org/5u82 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u82 RCSB], [http://www.ebi.ac.uk/pdbsum/5u82 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u82 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u82 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u82 OCA], [http://pdbe.org/5u82 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u82 RCSB], [http://www.ebi.ac.uk/pdbsum/5u82 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u82 ProSAT]</span></td></tr>
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: Alkylmercury lyase]]		[[Category: Alkylmercury lyase]]
	[[Category: Mansour, A]]		[[Category: Mansour, A]]

OCA at 16:41, 18 January 2017

OCA — Wed, 18 Jan 2017 16:41:55 GMT

←Older revision		Revision as of 16:41, 18 January 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5u82 is ~~ON HOLD~~	+	==Crystal structure of a MerB-triethyltin complex==
		+	<StructureSection load='5u82' size='340' side='right' caption='[[5u82]], [[Resolution\|resolution]] 1.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5u82]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U82 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U82 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=ZN0:TRIETHYLTIN+CHLORIDE'>ZN0</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f0p\|3f0p]], [[5c0u\|5c0u]], [[5c17\|5c17]], [[5c0t\|5c0t]], [[5u79\|5u79]], [[5u7a\|5u7a]], [[5u7c\|5u7c]], [[5u7b\|5u7b]], [[5u83\|5u83]], [[5u88\|5u88]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkylmercury_lyase Alkylmercury lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.99.1.2 4.99.1.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u82 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u82 OCA], [http://pdbe.org/5u82 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u82 RCSB], [http://www.ebi.ac.uk/pdbsum/5u82 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u82 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MERB_ECOLX MERB_ECOLX]] Cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. One product is Hg(2+), which is subsequently detoxified by the mercuric reductase (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The organomercurial lyase MerB has the unique ability to cleave carbon-Hg bonds, and structural studies indicate that three residues in the active site (C96, D99, and C159 in E. coli MerB) play important roles in the carbon-Hg bond cleavage. However, the role of each residue in carbon-metal bond cleavage has not been well-defined. To do so, we have structurally and biophysically characterized the interaction of MerB with a series of organotin and organolead compounds. Studies with two known inhibitors of MerB, dimethyltin (DMT) and triethyltin (TET), reveal that they inhibit by different mechanisms. In both cases the initial binding is to D99, but DMT subsequently binds to C96, which induces a conformation change in the active site. In contrast, diethyltin (DET) is a substrate for MerB and the SnIV product remains bound in the active site in a coordination similar to that of HgII following cleavage of organomercurial compounds. The results with analogous organolead compounds are similar in that trimethyllead (TML) is not cleaved and binds only to D99, whereas diethyllead (DEL) is a substrate and the PbIV product remains bound in the active site. Binding and cleavage is an exothermic reaction, while binding to D99 has negligible net heat flow. These results show that initial binding of organometallic compounds to MerB occurs at D99 followed, in some cases, by cleavage and loss of the organic moieties and binding of the metal ion product to C96, D99, and C159. The N-terminus of MerA is able to extract the bound PbVI but not the bound SnIV. These results suggest that MerB could be utilized for bioremediation applications, but certain organolead and organotin compounds may present an obstacle by inhibiting the enzyme.

-	~~Authors:~~ Wahba~~, H.M.~~, Stevenson~~, M.~~, Mansour, A., Sygusch, J., Wilcox~~, D.E.~~, Omichinski, J.G.	+	Structural and Biochemical Characterization of Organotin and Organolead Compounds Binding to the Organomercurial Lyase MerB Provide New Insights into Its Mechanism of Carbon-Metal Bond Cleavage.,Wahba HM, Stevenson MJ, Mansour A, Sygusch J, Wilcox DE, Omichinski JG J Am Chem Soc. 2017 Jan 3. doi: 10.1021/jacs.6b11327. PMID:27989130<ref>PMID:27989130</ref>

-	~~Description: Crystal structure~~ of ~~a MerB-triethyltin complex~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Wahba, H.M]]~~	+	<div class="pdbe-citations 5u82" style="background-color:#fffaf0;"></div>
-	~~[[Category: Wilcox, D.E]]~~	+	== References ==
-	[[Category: ~~Omichinski, J.G~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Alkylmercury lyase]]
	[[Category: Mansour, A]]		[[Category: Mansour, A]]
-	[[Category: ~~Sygusch~~, J]]	+	[[Category: Omichinski, J G]]
	[[Category: Stevenson, M]]		[[Category: Stevenson, M]]
		+	[[Category: Sygusch, J]]
		+	[[Category: Wahba, H M]]
		+	[[Category: Wilcox, D E]]
		+	[[Category: Bacterial protein]]
		+	[[Category: Cysteine]]
		+	[[Category: Escherichia coli]]
		+	[[Category: Lyase]]
		+	[[Category: Mercury]]
		+	[[Category: Metal binding protein]]
		+	[[Category: Triethyltin]]

OCA: Protected "5u82" [edit=sysop:move=sysop]

OCA — Thu, 22 Dec 2016 20:31:35 GMT

Protected "5u82" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:31, 22 December 2016

OCA: New page: '''Unreleased structure''' The entry 5u82 is ON HOLD Authors: Wahba, H.M., Stevenson, M., Mansour, A., Sygusch, J., Wilcox, D.E., Omichinski, J.G. Description: Crystal structure of a M...

OCA — Thu, 22 Dec 2016 20:31:34 GMT

New page: '''Unreleased structure''' The entry 5u82 is ON HOLD Authors: Wahba, H.M., Stevenson, M., Mansour, A., Sygusch, J., Wilcox, D.E., Omichinski, J.G. Description: Crystal structure of a M...

New page

'''Unreleased structure'''

The entry 5u82 is ON HOLD

Authors: Wahba, H.M., Stevenson, M., Mansour, A., Sygusch, J., Wilcox, D.E., Omichinski, J.G.

Description: Crystal structure of a MerB-triethyltin complex
[[Category: Unreleased Structures]]
[[Category: Wahba, H.M]]
[[Category: Wilcox, D.E]]
[[Category: Omichinski, J.G]]
[[Category: Mansour, A]]
[[Category: Sygusch, J]]
[[Category: Stevenson, M]]

←Older revision		Revision as of 11:42, 27 April 2022
Line 3:		Line 3:
	<StructureSection load='5u82' size='340' side='right'caption='[[5u82]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='5u82' size='340' side='right'caption='[[5u82]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5u82]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U82 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5U82 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5u82]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U82 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5U82 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=ZN0:TRIETHYLTIN+CHLORIDE'>ZN0</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=ZN0:TRIETHYLTIN+CHLORIDE'>ZN0</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f0p\|3f0p]], [[5c0u\|5c0u]], [[5c17\|5c17]], [[5c0t\|5c0t]], [[5u79\|5u79]], [[5u7a\|5u7a]], [[5u7c\|5u7c]], [[5u7b\|5u7b]], [[5u83\|5u83]], [[5u88\|5u88]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3f0p\|3f0p]], [[5c0u\|5c0u]], [[5c17\|5c17]], [[5c0t\|5c0t]], [[5u79\|5u79]], [[5u7a\|5u7a]], [[5u7c\|5u7c]], [[5u7b\|5u7b]], [[5u83\|5u83]], [[5u88\|5u88]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">merB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">merB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Alkylmercury_lyase Alkylmercury lyase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.99.1.2 4.99.1.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Alkylmercury_lyase Alkylmercury lyase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.99.1.2 4.99.1.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5u82 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u82 OCA], [~~http~~://pdbe.org/5u82 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5u82 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5u82 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5u82 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5u82 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u82 OCA], [https://pdbe.org/5u82 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5u82 RCSB], [https://www.ebi.ac.uk/pdbsum/5u82 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5u82 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MERB_ECOLX MERB_ECOLX]] Cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. One product is Hg(2+), which is subsequently detoxified by the mercuric reductase (By similarity).	+	[[https://www.uniprot.org/uniprot/MERB_ECOLX MERB_ECOLX]] Cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. One product is Hg(2+), which is subsequently detoxified by the mercuric reductase (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==