5uaz - Revision history

OCA at 13:24, 4 October 2023

OCA — Wed, 04 Oct 2023 13:24:25 GMT

←Older revision		Revision as of 13:24, 4 October 2023
Line 3:		Line 3:
	<StructureSection load='5uaz' size='340' side='right'caption='[[5uaz]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='5uaz' size='340' side='right'caption='[[5uaz]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5uaz]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UAZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5UAZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5uaz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UAZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=EDO:~~1~~,2-ETHANEDIOL'>EDO</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.753Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~NUP53, YMR153W, YM8520.02 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=559292 Baker~~'~~s yeast])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5uaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uaz OCA], [~~http~~://pdbe.org/5uaz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5uaz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5uaz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5uaz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uaz OCA], [https://pdbe.org/5uaz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uaz RCSB], [https://www.ebi.ac.uk/pdbsum/5uaz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uaz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NUP53_YEAST NUP53_YEAST]] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP53 may play an important role in cell cycle regulation by inhibiting PSE1 transport functions during mitosis and sequestration of MAD1-MAD2 in a cell cycle-dependent manner. It also seems to play an important role in de novo NPC assembly by associating with nuclear membranes and driving their proliferation.<ref>PMID:9864357</ref> <ref>PMID:11352933</ref> <ref>PMID:12403813</ref> <ref>PMID:12473689</ref> <ref>PMID:14697200</ref> <ref>PMID:12604785</ref>	+	[https://www.uniprot.org/uniprot/NUP53_YEAST NUP53_YEAST] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP53 may play an important role in cell cycle regulation by inhibiting PSE1 transport functions during mitosis and sequestration of MAD1-MAD2 in a cell cycle-dependent manner. It also seems to play an important role in de novo NPC assembly by associating with nuclear membranes and driving their proliferation.<ref>PMID:9864357</ref> <ref>PMID:11352933</ref> <ref>PMID:12403813</ref> <ref>PMID:12473689</ref> <ref>PMID:14697200</ref> <ref>PMID:12604785</ref>

	==See Also==		==See Also==
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Baker's yeast]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Blobel, G~~]]	+	[[Category: Saccharomyces cerevisiae S288C]]
-	[[Category: ~~Blus, B J~~]]	+	[[Category: Blobel G]]
-	[[Category: ~~Dimerization domain]]~~	+	[[Category: Blus BJ]]
-	~~[[Category: Nuclear pore complex]]~~	+
-	~~[[Category: Nucleocytoplasmic transport]]~~	+
-	~~[[Category: Nucleoporin]]~~	+
-	~~[[Category: Protein transport~~]]	+

OCA at 16:43, 20 November 2019

OCA — Wed, 20 Nov 2019 16:43:29 GMT

←Older revision		Revision as of 16:43, 20 November 2019
Line 1:		Line 1:

	==Crystal structure of the yeast nucleoporin==		==Crystal structure of the yeast nucleoporin==
-	<StructureSection load='5uaz' size='340' side='right' caption='[[5uaz]], [[Resolution\|resolution]] 1.75Å' scene=''>	+	<StructureSection load='5uaz' size='340' side='right'caption='[[5uaz]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5uaz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UAZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UAZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5uaz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UAZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UAZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUP53, YMR153W, YM8520.02 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uaz OCA], [http://pdbe.org/5uaz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uaz RCSB], [http://www.ebi.ac.uk/pdbsum/5uaz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uaz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uaz OCA], [http://pdbe.org/5uaz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uaz RCSB], [http://www.ebi.ac.uk/pdbsum/5uaz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uaz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/NUP53_YEAST NUP53_YEAST]] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP53 may play an important role in cell cycle regulation by inhibiting PSE1 transport functions during mitosis and sequestration of MAD1-MAD2 in a cell cycle-dependent manner. It also seems to play an important role in de novo NPC assembly by associating with nuclear membranes and driving their proliferation.<ref>PMID:9864357</ref> <ref>PMID:11352933</ref> <ref>PMID:12403813</ref> <ref>PMID:12473689</ref> <ref>PMID:14697200</ref> <ref>PMID:12604785</ref>		[[http://www.uniprot.org/uniprot/NUP53_YEAST NUP53_YEAST]] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP53 may play an important role in cell cycle regulation by inhibiting PSE1 transport functions during mitosis and sequestration of MAD1-MAD2 in a cell cycle-dependent manner. It also seems to play an important role in de novo NPC assembly by associating with nuclear membranes and driving their proliferation.<ref>PMID:9864357</ref> <ref>PMID:11352933</ref> <ref>PMID:12403813</ref> <ref>PMID:12473689</ref> <ref>PMID:14697200</ref> <ref>PMID:12604785</ref>
		+
		+	==See Also==
		+	*[[Nucleoporin 3D structures\|Nucleoporin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Baker's yeast]]
		+	[[Category: Large Structures]]
	[[Category: Blobel, G]]		[[Category: Blobel, G]]
	[[Category: Blus, B J]]		[[Category: Blus, B J]]

OCA at 08:26, 27 December 2017

OCA — Wed, 27 Dec 2017 08:26:34 GMT

←Older revision		Revision as of 08:26, 27 December 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5uaz is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Crystal structure of the yeast nucleoporin==
-		+	<StructureSection load='5uaz' size='340' side='right' caption='[[5uaz]], [[Resolution\|resolution]] 1.75Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5uaz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UAZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UAZ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uaz OCA], [http://pdbe.org/5uaz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uaz RCSB], [http://www.ebi.ac.uk/pdbsum/5uaz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uaz ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NUP53_YEAST NUP53_YEAST]] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP53 may play an important role in cell cycle regulation by inhibiting PSE1 transport functions during mitosis and sequestration of MAD1-MAD2 in a cell cycle-dependent manner. It also seems to play an important role in de novo NPC assembly by associating with nuclear membranes and driving their proliferation.<ref>PMID:9864357</ref> <ref>PMID:11352933</ref> <ref>PMID:12403813</ref> <ref>PMID:12473689</ref> <ref>PMID:14697200</ref> <ref>PMID:12604785</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Blobel, G]]
		+	[[Category: Blus, B J]]
		+	[[Category: Dimerization domain]]
		+	[[Category: Nuclear pore complex]]
		+	[[Category: Nucleocytoplasmic transport]]
		+	[[Category: Nucleoporin]]
		+	[[Category: Protein transport]]

OCA at 21:46, 25 January 2017

OCA — Wed, 25 Jan 2017 21:46:28 GMT

←Older revision		Revision as of 21:46, 25 January 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5uaz is ON HOLD	+	The entry 5uaz is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5uaz" [edit=sysop:move=sysop]

OCA — Mon, 02 Jan 2017 15:18:24 GMT

Protected "5uaz" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:18, 2 January 2017

OCA: New page: '''Unreleased structure''' The entry 5uaz is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Mon, 02 Jan 2017 15:18:23 GMT

New page: '''Unreleased structure''' The entry 5uaz is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5uaz is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]