5ubg - Revision history

OCA at 13:24, 4 October 2023

OCA — Wed, 04 Oct 2023 13:24:37 GMT

←Older revision		Revision as of 13:24, 4 October 2023
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	==Catalytic core domain of Adenosine triphosphate phosphoribosyltransferase from Campylobacter jejuni with bound Phosphoribosyl-ATP==		==Catalytic core domain of Adenosine triphosphate phosphoribosyltransferase from Campylobacter jejuni with bound Phosphoribosyl-ATP==
-	<StructureSection load='5ubg' size='340' side='right' caption='[[5ubg]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='5ubg' size='340' side='right'caption='[[5ubg]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ubg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Camjr Camjr~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UBG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5UBG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ubg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_jejuni_RM1221 Campylobacter jejuni RM1221]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UBG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UBG FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PRT:PHOSPHORIBOSYL+ATP'>PRT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ub9\|5ub9]]~~, [[~~5ubi~~\|~~5ubi]], [[5ubh\|5ubh~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PRT:PHOSPHORIBOSYL+ATP'>PRT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~hisG, CJE1769 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=195099 CAMJR])</td~~></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ubg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ubg OCA], [https://pdbe.org/5ubg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ubg RCSB], [https://www.ebi.ac.uk/pdbsum/5ubg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ubg ProSAT]</span></td></tr>
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/ATP_phosphoribosyltransferase ATP phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.17 2.4.2.17]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ubg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ubg OCA], [~~http~~://pdbe.org/5ubg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ubg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ubg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ubg ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HIS1_CAMJR HIS1_CAMJR]] Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.	+	[https://www.uniprot.org/uniprot/HIS1_CAMJR HIS1_CAMJR] Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5ubg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ubg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[ATP phosphoribosyl transferase 3D structures\|ATP phosphoribosyl transferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~ATP phosphoribosyltransferase~~]]	+	[[Category: Campylobacter jejuni RM1221]]
-	[[Category: ~~Camjr~~]]	+	[[Category: Large Structures]]
-	[[Category: Jiao, W]]	+	[[Category: Jiao W]]
-	[[Category: Livingstone~~, E K~~]]	+	[[Category: Livingstone EK]]
-	[[Category: Mittelstaedt, G]]	+	[[Category: Mittelstaedt G]]
-	[[Category: Parker~~, E J]]~~	+	[[Category: Parker EJ]]
-	~~[[Category: Hisg]]~~	+
-	~~[[Category: Histidine-biosynthesis]]~~	+
-	~~[[Category: Pr-atp]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:13, 17 January 2018

OCA — Wed, 17 Jan 2018 08:13:37 GMT

←Older revision		Revision as of 08:13, 17 January 2018
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	<StructureSection load='5ubg' size='340' side='right' caption='[[5ubg]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='5ubg' size='340' side='right' caption='[[5ubg]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ubg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UBG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ubg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camjr Camjr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UBG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PRT:PHOSPHORIBOSYL+ATP'>PRT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PRT:PHOSPHORIBOSYL+ATP'>PRT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ub9\|5ub9]], [[5ubi\|5ubi]], [[5ubh\|5ubh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ub9\|5ub9]], [[5ubi\|5ubi]], [[5ubh\|5ubh]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hisG, CJE1769 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=195099 CAMJR])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ATP_phosphoribosyltransferase ATP phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.17 2.4.2.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ATP_phosphoribosyltransferase ATP phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.17 2.4.2.17] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ubg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ubg OCA], [http://pdbe.org/5ubg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ubg RCSB], [http://www.ebi.ac.uk/pdbsum/5ubg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ubg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ubg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ubg OCA], [http://pdbe.org/5ubg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ubg RCSB], [http://www.ebi.ac.uk/pdbsum/5ubg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ubg ProSAT]</span></td></tr>
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	</StructureSection>		</StructureSection>
	[[Category: ATP phosphoribosyltransferase]]		[[Category: ATP phosphoribosyltransferase]]
		+	[[Category: Camjr]]
	[[Category: Jiao, W]]		[[Category: Jiao, W]]
	[[Category: Livingstone, E K]]		[[Category: Livingstone, E K]]

OCA at 06:16, 20 December 2017

OCA — Wed, 20 Dec 2017 06:16:07 GMT

←Older revision		Revision as of 06:16, 20 December 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ubg is ~~ON HOLD until Paper~~ Publication	+	==Catalytic core domain of Adenosine triphosphate phosphoribosyltransferase from Campylobacter jejuni with bound Phosphoribosyl-ATP==
		+	<StructureSection load='5ubg' size='340' side='right' caption='[[5ubg]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ubg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UBG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PRT:PHOSPHORIBOSYL+ATP'>PRT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ub9\|5ub9]], [[5ubi\|5ubi]], [[5ubh\|5ubh]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ATP_phosphoribosyltransferase ATP phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.17 2.4.2.17] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ubg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ubg OCA], [http://pdbe.org/5ubg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ubg RCSB], [http://www.ebi.ac.uk/pdbsum/5ubg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ubg ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HIS1_CAMJR HIS1_CAMJR]] Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ATP-phosphoribosyltransferase (ATP-PRT) catalyses the first committed step of histidine biosynthesis in plants and micro-organisms. Two forms of ATP-PRT have been reported, which differ in their molecular architecture and mechanism of allosteric regulation. The short-form ATP-PRT is a hetero-octamer, with four HisG chains that comprise only the catalytic domains and four separate chains of HisZ required for allosteric regulation by histidine. The long-form ATP-PRT is homohexameric, with each chain comprising two catalytic domains and a covalently linked regulatory domain that binds histidine as an allosteric inhibitor. Here, we describe a truncated long-form ATP-PRT from Campylobacter jejuni devoid of its regulatory domain ( Cje ATP-PRT(core)). Results showed that Cje ATP-PRT(core) is dimeric, exhibits attenuated catalytic activity, and is insensitive to histidine, indicating the covalently linked regulatory domain plays a role in both catalysis and regulation. Crystal structures were obtained for Cje ATP-PRT(core) in complex with both substrates, and for the first time, the complete product of the reaction. These structures reveal the key features of the active site, and provide insights into how substrates move into position during catalysis.

-	~~Authors: Mittelstaedt~~, G., Jiao, W., Livingstone, E~~.K.~~, ~~Parker~~, E.J.	+	A dimeric catalytic core relates the short and long forms of ATP-phosphoribosyltransferase.,Mittelstadt G, Jiao W, Livingstone E, Moggre GJ, Nazmi AR, Parker EJ Biochem J. 2017 Dec 5. pii: BCJ20170762. doi: 10.1042/BCJ20170762. PMID:29208762<ref>PMID:29208762</ref>

-	~~Description: Catalytic core domain~~ of ~~Adenosine triphosphate phosphoribosyltransferase from Campylobacter jejuni with bound Phosphoribosyl-ATP~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Livingstone, E.K~~]]	+	<div class="pdbe-citations 5ubg" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: ATP phosphoribosyltransferase]]
	[[Category: Jiao, W]]		[[Category: Jiao, W]]
-	[[Category: ~~Parker~~, E.J]]	+	[[Category: Livingstone, E K]]
	[[Category: Mittelstaedt, G]]		[[Category: Mittelstaedt, G]]
		+	[[Category: Parker, E J]]
		+	[[Category: Hisg]]
		+	[[Category: Histidine-biosynthesis]]
		+	[[Category: Pr-atp]]
		+	[[Category: Transferase]]

OCA at 08:58, 12 April 2017

OCA — Wed, 12 Apr 2017 08:58:23 GMT

←Older revision		Revision as of 08:58, 12 April 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ubg is ON HOLD	+	The entry 5ubg is ON HOLD until Paper Publication

	Authors: Mittelstaedt, G., Jiao, W., Livingstone, E.K., Parker, E.J.		Authors: Mittelstaedt, G., Jiao, W., Livingstone, E.K., Parker, E.J.

OCA at 14:38, 18 January 2017

OCA — Wed, 18 Jan 2017 14:38:58 GMT

←Older revision		Revision as of 14:38, 18 January 2017
Line 3:		Line 3:
	The entry 5ubg is ON HOLD		The entry 5ubg is ON HOLD

-	Authors: ~~Gerd~~ Mittelstaedt, ~~Wanting~~ Jiao, ~~Emma K~~ Livingstone, ~~Emily J~~ Parker	+	Authors: Mittelstaedt, G., Jiao, W., Livingstone, E.K., Parker, E.J.

	Description: Catalytic core domain of Adenosine triphosphate phosphoribosyltransferase from Campylobacter jejuni with bound Phosphoribosyl-ATP		Description: Catalytic core domain of Adenosine triphosphate phosphoribosyltransferase from Campylobacter jejuni with bound Phosphoribosyl-ATP
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Gerd Mittelstaedt~~, ~~Wanting~~ Jiao, ~~Emma K Livingstone~~, ~~Emily~~ J ~~Parker~~]]	+	[[Category: Livingstone, E.K]]
		+	[[Category: Jiao, W]]
		+	[[Category: Parker, E.J]]
		+	[[Category: Mittelstaedt, G]]

OCA: Protected "5ubg" [edit=sysop:move=sysop]

OCA — Mon, 02 Jan 2017 15:19:25 GMT

Protected "5ubg" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:19, 2 January 2017

OCA: New page: '''Unreleased structure''' The entry 5ubg is ON HOLD Authors: Gerd Mittelstaedt, Wanting Jiao, Emma K Livingstone, Emily J Parker Description: Catalytic core domain of Adenosine tripho...

OCA — Mon, 02 Jan 2017 15:19:23 GMT

New page: '''Unreleased structure''' The entry 5ubg is ON HOLD Authors: Gerd Mittelstaedt, Wanting Jiao, Emma K Livingstone, Emily J Parker Description: Catalytic core domain of Adenosine tripho...

New page

'''Unreleased structure'''

The entry 5ubg is ON HOLD

Authors: Gerd Mittelstaedt, Wanting Jiao, Emma K Livingstone, Emily J Parker

Description: Catalytic core domain of Adenosine triphosphate phosphoribosyltransferase from Campylobacter jejuni with bound Phosphoribosyl-ATP
[[Category: Unreleased Structures]]
[[Category: Gerd Mittelstaedt, Wanting Jiao, Emma K Livingstone, Emily J Parker]]