5ubp - Revision history

OCA at 12:31, 23 September 2020

OCA — Wed, 23 Sep 2020 12:31:42 GMT

←Older revision		Revision as of 12:31, 23 September 2020
Line 1:		Line 1:

	==TREX2 M-region==		==TREX2 M-region==
-	<StructureSection load='5ubp' size='340' side='right' caption='[[5ubp]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='5ubp' size='340' side='right'caption='[[5ubp]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ubp]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UBP OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5UBP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ubp]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UBP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5UBP FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ubp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ubp OCA], [http://pdbe.org/5ubp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ubp RCSB], [http://www.ebi.ac.uk/pdbsum/5ubp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ubp ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ubp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ubp OCA], [http://pdbe.org/5ubp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ubp RCSB], [http://www.ebi.ac.uk/pdbsum/5ubp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ubp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 5ubp" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ubp" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Proteasome 3D structures\|Proteasome 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Gordon, J]]		[[Category: Gordon, J]]
	[[Category: Stewart, M]]		[[Category: Stewart, M]]

OCA at 13:18, 5 April 2017

OCA — Wed, 05 Apr 2017 13:18:41 GMT

←Older revision		Revision as of 13:18, 5 April 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ubp is ~~ON HOLD~~	+	==TREX2 M-region==
		+	<StructureSection load='5ubp' size='340' side='right' caption='[[5ubp]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ubp]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UBP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UBP FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ubp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ubp OCA], [http://pdbe.org/5ubp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ubp RCSB], [http://www.ebi.ac.uk/pdbsum/5ubp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ubp ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SEM1_YEAST SEM1_YEAST]] Versatile protein that might stabilize multiple protein complexes involved in diverse pathways. Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis. Associates also with the TREX-2 complex that is required for transcription-coupled mRNA export, and the COP9 signalosome, which is involved in deneddylation.<ref>PMID:19289793</ref> <ref>PMID:15117943</ref> [[http://www.uniprot.org/uniprot/THP1_YEAST THP1_YEAST]] Component of the SAC3-THP1 complex, which functions in transcription-coupled mRNA export from the nucleus to the cytoplasm. SAC3-THP1 functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), by association with components of the nuclear mRNA export machinery (MEX67-MTR2 and SUB2) in the nucleoplasm and the nucleoporin NUP1 at the nuclear basket. THP1 binds to RNA in vitro.<ref>PMID:11139493</ref> <ref>PMID:12411502</ref> <ref>PMID:12702719</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Transcription-export complex 2 (TREX-2, or THSC) facilitates localization of actively transcribing genes such as GAL1 to the nuclear periphery, contributes to the generation of export-competent mRNPs and influences gene expression through interactions with Mediator. TREX-2 is based on a Sac3 scaffold to which Thp1, Sem1, Cdc31 and Sus1 bind and consists of three modules: the N-region (Sac3 approximately 1-100), which binds mRNA export factor Mex67:Mtr2; the M-region, in which Thp1 and Sem1 bind to Sac3 approximately 100-550; and the CID region in which Cdc31 and two Sus1 chains bind to Sac3 approximately 720-805. Although the M-region of Sac3 was originally thought to encompass residues approximately 250-550, we report here the 2.3A resolution crystal structure of a complex containing Sac3 residues 60-550 that indicates that the TPR-like repeats of the M-region extend to residue 137 and that residues 90-125 form a novel loop that links Sac3 to Thp1. These new structural elements are important for growth and mRNA export in vivo. Although deleting Sac3 residues 1-90 produced a wild-type phenotype, deletion of the loop as well generated growth defects at 37 degrees C, whereas the deletion of residues 1-250 impaired mRNA export and also generated longer lag times when glucose or raffinose was replaced by galactose as the carbon source.

-	~~Authors~~:	+	Structure of the Sac3 RNA-binding M-region in the Saccharomyces cerevisiae TREX-2 complex.,Gordon JM, Aibara S, Stewart M Nucleic Acids Res. 2017 Mar 15. doi: 10.1093/nar/gkx158. PMID:28334829<ref>PMID:28334829</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5ubp" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gordon, J]]
		+	[[Category: Stewart, M]]
		+	[[Category: Tpr repeat]]
		+	[[Category: Transcription]]
		+	[[Category: Trex2 complex]]

OCA: Protected "5ubp" [edit=sysop:move=sysop]

OCA — Mon, 02 Jan 2017 15:20:00 GMT

Protected "5ubp" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:20, 2 January 2017

OCA: New page: '''Unreleased structure''' The entry 5ubp is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Mon, 02 Jan 2017 15:19:59 GMT

New page: '''Unreleased structure''' The entry 5ubp is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5ubp is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]