5uhm - Revision history

OCA at 13:27, 4 October 2023

OCA — Wed, 04 Oct 2023 13:27:32 GMT

←Older revision		Revision as of 13:27, 4 October 2023
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	<StructureSection load='5uhm' size='340' side='right'caption='[[5uhm]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='5uhm' size='340' side='right'caption='[[5uhm]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5uhm]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UHM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5UHM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5uhm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UHM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UHM FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~GDF11~~, ~~BMP11 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5uhm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uhm OCA], [~~http~~://pdbe.org/5uhm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5uhm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5uhm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5uhm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uhm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uhm OCA], [https://pdbe.org/5uhm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uhm RCSB], [https://www.ebi.ac.uk/pdbsum/5uhm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uhm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GDF11_HUMAN GDF11_HUMAN]] Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern.	+	[https://www.uniprot.org/uniprot/GDF11_HUMAN GDF11_HUMAN] Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Goebel, E]]	+	[[Category: Goebel E]]
-	[[Category: Thompson, T]]	+	[[Category: Thompson T]]
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Tgfb gdf11 apo activin~~]]	+

OCA at 12:36, 23 September 2020

OCA — Wed, 23 Sep 2020 12:36:44 GMT

←Older revision		Revision as of 12:36, 23 September 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 5uhm is ~~ON HOLD until Paper~~ Publication	+	==Apo-Structure of Mature Growth Differentiation Factor 11==
		+	<StructureSection load='5uhm' size='340' side='right'caption='[[5uhm]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5uhm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UHM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5UHM FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GDF11, BMP11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5uhm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uhm OCA], [http://pdbe.org/5uhm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uhm RCSB], [http://www.ebi.ac.uk/pdbsum/5uhm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uhm ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GDF11_HUMAN GDF11_HUMAN]] Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: Growth/differentiation factor 8 (GDF8) and GDF11 are two highly similar members of the transforming growth factor beta (TGFbeta) family. While GDF8 has been recognized as a negative regulator of muscle growth and differentiation, there are conflicting studies on the function of GDF11 and whether GDF11 has beneficial effects on age-related dysfunction. To address whether GDF8 and GDF11 are functionally identical, we compared their signaling and structural properties. RESULTS: Here we show that, despite their high similarity, GDF11 is a more potent activator of SMAD2/3 and signals more effectively through the type I activin-like receptor kinase receptors ALK4/5/7 than GDF8. Resolution of the GDF11:FS288 complex, apo-GDF8, and apo-GDF11 crystal structures reveals unique properties of both ligands, specifically in the type I receptor binding site. Lastly, substitution of GDF11 residues into GDF8 confers enhanced activity to GDF8. CONCLUSIONS: These studies identify distinctive structural features of GDF11 that enhance its potency, relative to GDF8; however, the biological consequences of these differences remain to be determined.

-	~~Authors:~~ Goebel, E., ~~Thompson~~, T.	+	Structural basis for potency differences between GDF8 and GDF11.,Walker RG, Czepnik M, Goebel EJ, McCoy JC, Vujic A, Cho M, Oh J, Aykul S, Walton KL, Schang G, Bernard DJ, Hinck AP, Harrison CA, Martinez-Hackert E, Wagers AJ, Lee RT, Thompson TB BMC Biol. 2017 Mar 3;15(1):19. doi: 10.1186/s12915-017-0350-1. PMID:28257634<ref>PMID:28257634</ref>

-	~~Description: Apo-Structure~~ of ~~Mature~~ Growth ~~Differentiation Factor 11~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Thompson, T~~]]	+	<div class="pdbe-citations 5uhm" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Growth differentiation factor 3D STRUCTURES\|Growth differentiation factor 3D STRUCTURES]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Goebel, E]]		[[Category: Goebel, E]]
		+	[[Category: Thompson, T]]
		+	[[Category: Signaling protein]]
		+	[[Category: Tgfb gdf11 apo activin]]

OCA at 19:03, 15 March 2017

OCA — Wed, 15 Mar 2017 19:03:55 GMT

←Older revision		Revision as of 19:03, 15 March 2017
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	Description: Apo-Structure of Mature Growth Differentiation Factor 11		Description: Apo-Structure of Mature Growth Differentiation Factor 11
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Goebel, E]]
	[[Category: Thompson, T]]		[[Category: Thompson, T]]
		+	[[Category: Goebel, E]]

OCA at 21:58, 25 January 2017

OCA — Wed, 25 Jan 2017 21:58:50 GMT

←Older revision		Revision as of 21:58, 25 January 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5uhm is ON HOLD	+	The entry 5uhm is ON HOLD until Paper Publication

	Authors: Goebel, E., Thompson, T.		Authors: Goebel, E., Thompson, T.

-	Description: ~~GDF11~~ Apo	+	Description: Apo-Structure of Mature Growth Differentiation Factor 11
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Goebel, E]]		[[Category: Goebel, E]]
	[[Category: Thompson, T]]		[[Category: Thompson, T]]

OCA: Protected "5uhm" [edit=sysop:move=sysop]

OCA — Wed, 18 Jan 2017 15:01:03 GMT

Protected "5uhm" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:01, 18 January 2017

OCA: New page: '''Unreleased structure''' The entry 5uhm is ON HOLD Authors: Goebel, E., Thompson, T. Description: GDF11 Apo Category: Unreleased Structures Category: Goebel, E [[Category: Th...

OCA — Wed, 18 Jan 2017 15:01:02 GMT

New page: '''Unreleased structure''' The entry 5uhm is ON HOLD Authors: Goebel, E., Thompson, T. Description: GDF11 Apo Category: Unreleased Structures Category: Goebel, E [[Category: Th...

New page

'''Unreleased structure'''

The entry 5uhm is ON HOLD

Authors: Goebel, E., Thompson, T.

Description: GDF11 Apo
[[Category: Unreleased Structures]]
[[Category: Goebel, E]]
[[Category: Thompson, T]]