5uho - Revision history

OCA at 14:27, 6 March 2024

OCA — Wed, 06 Mar 2024 14:27:25 GMT

←Older revision		Revision as of 14:27, 6 March 2024
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	<StructureSection load='5uho' size='340' side='right'caption='[[5uho]], [[Resolution\|resolution]] 3.21Å' scene=''>		<StructureSection load='5uho' size='340' side='right'caption='[[5uho]], [[Resolution\|resolution]] 3.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5uho]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UHO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5UHO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5uho]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UHO FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=OAN:O~~-~~(2-ACETAMIDO-2-DEOXY+D-GLUCOPYRANOSYLIDENE)+AMINO-N-PHENYLCARBAMATE'>OAN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.21Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5uhp\|5uhp]], [[5uhl\|5uhl]], [[5uhk\|5uhk]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OAN:O-(2-ACETAMIDO-2-DEOXY+D-GLUCOPYRANOSYLIDENE)+AMINO-N-PHENYLCARBAMATE'>OAN</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">MGEA5, HEXC, KIAA0679, MEA5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uho OCA], [https://pdbe.org/5uho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uho RCSB], [https://www.ebi.ac.uk/pdbsum/5uho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uho ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5uho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uho OCA], [~~http~~://pdbe.org/5uho PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5uho RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5uho PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5uho ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/OGA_HUMAN OGA_HUMAN]] Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).<ref>PMID:11148210</ref> <ref>PMID:11788610</ref> <ref>PMID:20673219</ref> <ref>PMID:22365600</ref> <ref>PMID:24088714</ref> Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.<ref>PMID:20673219</ref>	+	[https://www.uniprot.org/uniprot/OGA_HUMAN OGA_HUMAN] Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).<ref>PMID:11148210</ref> <ref>PMID:11788610</ref> <ref>PMID:20673219</ref> <ref>PMID:22365600</ref> <ref>PMID:24088714</ref> Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.<ref>PMID:20673219</ref>
		+
		+	==See Also==
		+	*[[O-GlcNAcase\|O-GlcNAcase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Elsen~~, N L~~]]	+	[[Category: Elsen NL]]
-	[[Category: Klein~~, D J]]~~	+	[[Category: Klein DJ]]
-	~~[[Category: Enzyme]]~~	+
-	~~[[Category: Gh84]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: O-glcnacase]]~~	+
-	~~[[Category: Pugnac~~]]	+

OCA at 12:36, 23 September 2020

OCA — Wed, 23 Sep 2020 12:36:53 GMT

←Older revision		Revision as of 12:36, 23 September 2020
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	==Crystal structure of the core catalytic domain of human O-GlcNAcase complexed with PUGNAc==		==Crystal structure of the core catalytic domain of human O-GlcNAcase complexed with PUGNAc==
-	<StructureSection load='5uho' size='340' side='right' caption='[[5uho]], [[Resolution\|resolution]] 3.21Å' scene=''>	+	<StructureSection load='5uho' size='340' side='right'caption='[[5uho]], [[Resolution\|resolution]] 3.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5uho]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UHO OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5UHO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5uho]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UHO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5UHO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OAN:O-(2-ACETAMIDO-2-DEOXY+D-GLUCOPYRANOSYLIDENE)+AMINO-N-PHENYLCARBAMATE'>OAN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OAN:O-(2-ACETAMIDO-2-DEOXY+D-GLUCOPYRANOSYLIDENE)+AMINO-N-PHENYLCARBAMATE'>OAN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5uhp\|5uhp]], [[5uhl\|5uhl]], [[5uhk\|5uhk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5uhp\|5uhp]], [[5uhl\|5uhl]], [[5uhk\|5uhk]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5uho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uho OCA], [http://pdbe.org/5uho PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uho RCSB], [http://www.ebi.ac.uk/pdbsum/5uho PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uho ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MGEA5, HEXC, KIAA0679, MEA5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5uho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uho OCA], [http://pdbe.org/5uho PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uho RCSB], [http://www.ebi.ac.uk/pdbsum/5uho PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uho ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Elsen, N L]]		[[Category: Elsen, N L]]
	[[Category: Klein, D J]]		[[Category: Klein, D J]]

OCA at 14:05, 29 March 2017

OCA — Wed, 29 Mar 2017 14:05:19 GMT

←Older revision		Revision as of 14:05, 29 March 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5uho is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Crystal structure of the core catalytic domain of human O-GlcNAcase complexed with PUGNAc==
-		+	<StructureSection load='5uho' size='340' side='right' caption='[[5uho]], [[Resolution\|resolution]] 3.21Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5uho]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UHO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UHO FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OAN:O-(2-ACETAMIDO-2-DEOXY+D-GLUCOPYRANOSYLIDENE)+AMINO-N-PHENYLCARBAMATE'>OAN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5uhp\|5uhp]], [[5uhl\|5uhl]], [[5uhk\|5uhk]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uho OCA], [http://pdbe.org/5uho PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uho RCSB], [http://www.ebi.ac.uk/pdbsum/5uho PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uho ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/OGA_HUMAN OGA_HUMAN]] Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).<ref>PMID:11148210</ref> <ref>PMID:11788610</ref> <ref>PMID:20673219</ref> <ref>PMID:22365600</ref> <ref>PMID:24088714</ref> Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.<ref>PMID:20673219</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Elsen, N L]]
		+	[[Category: Klein, D J]]
		+	[[Category: Enzyme]]
		+	[[Category: Gh84]]
		+	[[Category: Hydrolase]]
		+	[[Category: O-glcnacase]]
		+	[[Category: Pugnac]]

OCA at 21:58, 25 January 2017

OCA — Wed, 25 Jan 2017 21:58:57 GMT

←Older revision		Revision as of 21:58, 25 January 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5uho is ON HOLD	+	The entry 5uho is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5uho" [edit=sysop:move=sysop]

OCA — Wed, 18 Jan 2017 15:01:13 GMT

Protected "5uho" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:01, 18 January 2017

OCA: New page: '''Unreleased structure''' The entry 5uho is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 18 Jan 2017 15:01:12 GMT

New page: '''Unreleased structure''' The entry 5uho is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5uho is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]