5uhr - Revision history

OCA at 10:00, 15 November 2023

OCA — Wed, 15 Nov 2023 10:00:10 GMT

←Older revision		Revision as of 10:00, 15 November 2023
Line 3:		Line 3:
	<StructureSection load='5uhr' size='340' side='right'caption='[[5uhr]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='5uhr' size='340' side='right'caption='[[5uhr]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5uhr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UHR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5UHR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5uhr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UHR FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.798Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=A8E:(2S)-2-AMINO-4-BROMOPENT-4-ENOIC+ACID'>A8E</scene>, <scene name='pdbligand=CIR:CITRULLINE'>CIR</scene>, <scene name='pdbligand=HAO:{[3-(HYDRAZINOCARBONYL)-4-METHOXYPHENYL]AMINO}(OXO)ACETIC+ACID'>HAO</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A8E:(2S)-2-AMINO-4-BROMOPENT-4-ENOIC+ACID'>A8E</scene>, <scene name='pdbligand=CIR:CITRULLINE'>CIR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HAO:{[3-(HYDRAZINOCARBONYL)-4-METHOXYPHENYL]AMINO}(OXO)ACETIC+ACID'>HAO</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5uhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uhr OCA], [~~http~~://pdbe.org/5uhr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5uhr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5uhr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5uhr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uhr OCA], [https://pdbe.org/5uhr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uhr RCSB], [https://www.ebi.ac.uk/pdbsum/5uhr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uhr ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kreutzer~~, A G~~]]	+	[[Category: Kreutzer AG]]
-	[[Category: Nowick~~, J S~~]]	+	[[Category: Nowick JS]]
-	[[Category: Wang, Y]]	+	[[Category: Wang Y]]
-	~~[[Category: Amyloid]]~~	+
-	~~[[Category: De novo protein]]~~	+
-	~~[[Category: Diabetes]]~~	+
-	~~[[Category: Oligomer]]~~	+
-	~~[[Category: Tetramer~~]]	+

OCA at 12:36, 23 September 2020

OCA — Wed, 23 Sep 2020 12:36:52 GMT

←Older revision		Revision as of 12:36, 23 September 2020
Line 1:		Line 1:

	==Crystal structure of (Cit)LANFLV heptapeptide segment from islet amyloid polypeptide (IAPP) incorporated into a macrocyclic beta-sheet template==		==Crystal structure of (Cit)LANFLV heptapeptide segment from islet amyloid polypeptide (IAPP) incorporated into a macrocyclic beta-sheet template==
-	<StructureSection load='5uhr' size='340' side='right' caption='[[5uhr]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='5uhr' size='340' side='right'caption='[[5uhr]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5uhr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UHR OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5UHR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5uhr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UHR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5UHR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=A8E:(2S)-2-AMINO-4-BROMOPENT-4-ENOIC+ACID'>A8E</scene>, <scene name='pdbligand=CIR:CITRULLINE'>CIR</scene>, <scene name='pdbligand=HAO:{[3-(HYDRAZINOCARBONYL)-4-METHOXYPHENYL]AMINO}(OXO)ACETIC+ACID'>HAO</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=A8E:(2S)-2-AMINO-4-BROMOPENT-4-ENOIC+ACID'>A8E</scene>, <scene name='pdbligand=CIR:CITRULLINE'>CIR</scene>, <scene name='pdbligand=HAO:{[3-(HYDRAZINOCARBONYL)-4-METHOXYPHENYL]AMINO}(OXO)ACETIC+ACID'>HAO</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5uhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uhr OCA], [http://pdbe.org/5uhr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uhr RCSB], [http://www.ebi.ac.uk/pdbsum/5uhr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uhr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5uhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uhr OCA], [http://pdbe.org/5uhr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uhr RCSB], [http://www.ebi.ac.uk/pdbsum/5uhr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uhr ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Kreutzer, A G]]		[[Category: Kreutzer, A G]]
	[[Category: Nowick, J S]]		[[Category: Nowick, J S]]

OCA at 06:04, 17 August 2017

OCA — Thu, 17 Aug 2017 06:04:25 GMT

←Older revision		Revision as of 06:04, 17 August 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5uhr is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of (Cit)LANFLV heptapeptide segment from islet amyloid polypeptide (IAPP) incorporated into a macrocyclic beta-sheet template==
		+	<StructureSection load='5uhr' size='340' side='right' caption='[[5uhr]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5uhr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UHR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UHR FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=A8E:(2S)-2-AMINO-4-BROMOPENT-4-ENOIC+ACID'>A8E</scene>, <scene name='pdbligand=CIR:CITRULLINE'>CIR</scene>, <scene name='pdbligand=HAO:{[3-(HYDRAZINOCARBONYL)-4-METHOXYPHENYL]AMINO}(OXO)ACETIC+ACID'>HAO</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uhr OCA], [http://pdbe.org/5uhr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uhr RCSB], [http://www.ebi.ac.uk/pdbsum/5uhr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uhr ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aggregation of the islet amyloid polypeptide (IAPP) to form fibrils and oligomers is important in the progression of type 2 diabetes. This article describes X-ray crystallographic and solution-state NMR studies of peptides derived from residues 11-17 of IAPP that assemble to form tetramers. Incorporation of residues 11-17 of IAPP (RLANFLV) into a macrocyclic beta-sheet peptide results in a monomeric peptide that does not self-assemble to form oligomers. Mutation of Arg11 to the uncharged isostere citrulline gives peptide homologues that assemble to form tetramers in both the crystal state and in aqueous solution. The tetramers consist of hydrogen-bonded dimers that sandwich together through hydrophobic interactions. The tetramers share several features with structures reported for IAPP fibrils and demonstrate the importance of hydrogen bonding and hydrophobic interactions in the oligomerization of IAPP-derived peptides.

-	~~Authors~~:	+	A Tetramer Derived from Islet Amyloid Polypeptide.,Wang Y, Kreutzer AG, Truex NL, Nowick JS J Org Chem. 2017 Aug 4;82(15):7905-7912. doi: 10.1021/acs.joc.7b01116. Epub 2017 , Jul 14. PMID:28661686<ref>PMID:28661686</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5uhr" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Kreutzer, A G]]
		+	[[Category: Nowick, J S]]
		+	[[Category: Wang, Y]]
		+	[[Category: Amyloid]]
		+	[[Category: De novo protein]]
		+	[[Category: Diabetes]]
		+	[[Category: Oligomer]]
		+	[[Category: Tetramer]]

OCA at 14:29, 9 March 2017

OCA — Thu, 09 Mar 2017 14:29:12 GMT

←Older revision		Revision as of 14:29, 9 March 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5uhr is ON HOLD	+	The entry 5uhr is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5uhr" [edit=sysop:move=sysop]

OCA — Wed, 18 Jan 2017 15:01:22 GMT

Protected "5uhr" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:01, 18 January 2017

OCA: New page: '''Unreleased structure''' The entry 5uhr is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 18 Jan 2017 15:01:21 GMT

New page: '''Unreleased structure''' The entry 5uhr is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5uhr is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]