5uic - Revision history

OCA at 13:27, 4 October 2023

OCA — Wed, 04 Oct 2023 13:27:53 GMT

←Older revision		Revision as of 13:27, 4 October 2023
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	<StructureSection load='5uic' size='340' side='right'caption='[[5uic]], [[Resolution\|resolution]] 2.49Å' scene=''>		<StructureSection load='5uic' size='340' side='right'caption='[[5uic]], [[Resolution\|resolution]] 2.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5uic]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Fratn Fratn~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UIC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5UIC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5uic]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Francisella_tularensis_subsp._novicida_U112 Francisella tularensis subsp. novicida U112]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UIC FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~FTN_1465 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=401614 FRATN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.487Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5uic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uic OCA], [~~http~~://pdbe.org/5uic PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5uic RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5uic PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5uic ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uic OCA], [https://pdbe.org/5uic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uic RCSB], [https://www.ebi.ac.uk/pdbsum/5uic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uic ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0Q7W8_FRATN A0Q7W8_FRATN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Fratn~~]]	+	[[Category: Francisella tularensis subsp. novicida U112]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Allen~~, C L~~]]	+	[[Category: Allen CL]]
-	[[Category: Cavanagh, J]]	+	[[Category: Cavanagh J]]
-	[[Category: Milton~~, M E]]~~	+	[[Category: Milton ME]]
-	~~[[Category: Biofilm]]~~	+
-	~~[[Category: Francisella]]~~	+
-	~~[[Category: Qseb]]~~	+
-	~~[[Category: Response regulator]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Two component system~~]]	+

OCA at 09:17, 1 January 2020

OCA — Wed, 01 Jan 2020 09:17:11 GMT

←Older revision		Revision as of 09:17, 1 January 2020
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	==Structure of the Francisella response regulator receiver domain, QseB==		==Structure of the Francisella response regulator receiver domain, QseB==
-	<StructureSection load='5uic' size='340' side='right' caption='[[5uic]], [[Resolution\|resolution]] 2.49Å' scene=''>	+	<StructureSection load='5uic' size='340' side='right'caption='[[5uic]], [[Resolution\|resolution]] 2.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5uic]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UIC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5uic]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Fratn Fratn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UIC FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uic OCA], [http://pdbe.org/5uic PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uic RCSB], [http://www.ebi.ac.uk/pdbsum/5uic PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uic ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FTN_1465 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=401614 FRATN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uic OCA], [http://pdbe.org/5uic PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uic RCSB], [http://www.ebi.ac.uk/pdbsum/5uic PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uic ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 5uic" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5uic" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Response regulator 3D structure\|Response regulator 3D structure]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Fratn]]
		+	[[Category: Large Structures]]
	[[Category: Allen, C L]]		[[Category: Allen, C L]]
	[[Category: Cavanagh, J]]		[[Category: Cavanagh, J]]

OCA at 10:09, 18 October 2017

OCA — Wed, 18 Oct 2017 10:09:42 GMT

←Older revision		Revision as of 10:09, 18 October 2017
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	</div>		</div>
	<div class="pdbe-citations 5uic" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5uic" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Response regulator\|Response regulator]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:16, 6 October 2017

OCA — Fri, 06 Oct 2017 08:16:27 GMT

←Older revision		Revision as of 08:16, 6 October 2017
Line 15:		Line 15:
	</div>		</div>
	<div class="pdbe-citations 5uic" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5uic" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Response regulator\|Response regulator]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:54, 17 August 2017

OCA — Thu, 17 Aug 2017 05:54:30 GMT

←Older revision		Revision as of 05:54, 17 August 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5uic is ~~ON HOLD until Paper~~ Publication	+	==Structure of the Francisella response regulator receiver domain, QseB==
		+	<StructureSection load='5uic' size='340' side='right' caption='[[5uic]], [[Resolution\|resolution]] 2.49Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5uic]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UIC FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uic OCA], [http://pdbe.org/5uic PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uic RCSB], [http://www.ebi.ac.uk/pdbsum/5uic PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uic ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	With antibiotic resistance increasing at alarming rates, targets for new antimicrobial therapies must be identified. A particularly promising target is the bacterial two-component system. Two-component systems allow bacteria to detect, evaluate and protect themselves against changes in the environment, such as exposure to antibiotics, and also to trigger production of virulence factors. Drugs that target the response regulator portion of two-component systems represent a potent new approach so far unexploited. Here we focus efforts on the highly virulent bacterium Francisella tularensis tularensis. Francisella contains only three response regulators, making it an ideal system to study. In this study, we initially present the structure of the N-terminal domain of QseB, the response regulator responsible for biofilm formation. Subsequently, using binding assays, computational docking and cellular studies, we show that QseB interacts with2-aminoimidazole based compounds that impede its function. This information will assist in tailoring compounds to act as adjuvants that will enhance the effect of antibiotics. This article is protected by copyright. All rights reserved.

-	~~Authors: Allen~~, ~~C.L~~., Milton, ~~M.E.~~, ~~Cavanagh~~, J.	+	Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds.,Milton ME, Leigh Allen C, Feldmann EA, Bobay BG, Jung DK, Stephens MD, Melander RJ, Theisen KE, Zeng D, Thompson RJ, Melander C, Cavanagh J Mol Microbiol. 2017 Jul 29. doi: 10.1111/mmi.13759. PMID:28755524<ref>PMID:28755524</ref>

-	~~Description: Structure~~ of the ~~Francisella response regulator receiver domain, QseB~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: Allen, C.L]]	+	<div class="pdbe-citations 5uic" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Allen, C L]]
	[[Category: Cavanagh, J]]		[[Category: Cavanagh, J]]
-	[[Category: Milton, M.E]]	+	[[Category: Milton, M E]]
		+	[[Category: Biofilm]]
		+	[[Category: Francisella]]
		+	[[Category: Qseb]]
		+	[[Category: Response regulator]]
		+	[[Category: Transcription]]
		+	[[Category: Two component system]]

OCA at 14:29, 9 March 2017

OCA — Thu, 09 Mar 2017 14:29:47 GMT

←Older revision		Revision as of 14:29, 9 March 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5uic is ON HOLD	+	The entry 5uic is ON HOLD until Paper Publication

	Authors: Allen, C.L., Milton, M.E., Cavanagh, J.		Authors: Allen, C.L., Milton, M.E., Cavanagh, J.

OCA at 16:39, 1 February 2017

OCA — Wed, 01 Feb 2017 16:39:10 GMT

←Older revision		Revision as of 16:39, 1 February 2017
Line 3:		Line 3:
	The entry 5uic is ON HOLD		The entry 5uic is ON HOLD

-	Authors: C.~~Leigh Allen~~, ~~Morgan~~ E.~~Milton~~, ~~John~~ Cavanagh	+	Authors: Allen, C.L., Milton, M.E., Cavanagh, J.

	Description: Structure of the Francisella response regulator receiver domain, QseB		Description: Structure of the Francisella response regulator receiver domain, QseB
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~C.Leigh~~ Allen, ~~Morgan E~~.Milton, ~~John Cavanagh~~]]	+	[[Category: Allen, C.L]]
		+	[[Category: Cavanagh, J]]
		+	[[Category: Milton, M.E]]

OCA: Protected "5uic" [edit=sysop:move=sysop]

OCA — Wed, 25 Jan 2017 22:09:28 GMT

Protected "5uic" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:09, 25 January 2017

OCA: New page: '''Unreleased structure''' The entry 5uic is ON HOLD Authors: C.Leigh Allen, Morgan E.Milton, John Cavanagh Description: Structure of the Francisella response regulator receiver domain...

OCA — Wed, 25 Jan 2017 22:09:26 GMT

New page: '''Unreleased structure''' The entry 5uic is ON HOLD Authors: C.Leigh Allen, Morgan E.Milton, John Cavanagh Description: Structure of the Francisella response regulator receiver domain...

New page

'''Unreleased structure'''

The entry 5uic is ON HOLD

Authors: C.Leigh Allen, Morgan E.Milton, John Cavanagh

Description: Structure of the Francisella response regulator receiver domain, QseB
[[Category: Unreleased Structures]]
[[Category: C.Leigh Allen, Morgan E.Milton, John Cavanagh]]