5uj4 - Revision history

OCA at 17:08, 11 December 2019

OCA — Wed, 11 Dec 2019 17:08:06 GMT

←Older revision		Revision as of 17:08, 11 December 2019
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	==Crystal structure of the KPC-2 beta-lactamase complexed with hydrolyzed faropenem==		==Crystal structure of the KPC-2 beta-lactamase complexed with hydrolyzed faropenem==
-	<StructureSection load='5uj4' size='340' side='right' caption='[[5uj4]], [[Resolution\|resolution]] 1.40Å' scene=''>	+	<StructureSection load='5uj4' size='340' side='right'caption='[[5uj4]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5uj4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UJ4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5uj4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UJ4 FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 5uj4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5uj4" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
		+	[[Category: Large Structures]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]
	[[Category: Pemberton, O A]]		[[Category: Pemberton, O A]]

OCA at 19:39, 15 November 2017

OCA — Wed, 15 Nov 2017 19:39:27 GMT

←Older revision		Revision as of 19:39, 15 November 2017
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	<StructureSection load='5uj4' size='340' side='right' caption='[[5uj4]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='5uj4' size='340' side='right' caption='[[5uj4]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5uj4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UJ4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5uj4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UJ4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SFR:(2R)-2-[(1S,2R)-1-CARBOXY-2-HYDROXYPROPYL]-5-[(2R)-OXOLAN-2-YL]-2,3-DIHYDRO-1,3-THIAZOLE-4-CARBOXYLIC+ACID'>SFR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SFR:(2R)-2-[(1S,2R)-1-CARBOXY-2-HYDROXYPROPYL]-5-[(2R)-OXOLAN-2-YL]-2,3-DIHYDRO-1,3-THIAZOLE-4-CARBOXYLIC+ACID'>SFR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5uj3\|5uj3]], [[5ul8\|5ul8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5uj3\|5uj3]], [[5ul8\|5ul8]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bla, kpc, kpc1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uj4 OCA], [http://pdbe.org/5uj4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uj4 RCSB], [http://www.ebi.ac.uk/pdbsum/5uj4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uj4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uj4 OCA], [http://pdbe.org/5uj4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uj4 RCSB], [http://www.ebi.ac.uk/pdbsum/5uj4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uj4 ProSAT]</span></td></tr>

OCA at 13:53, 27 April 2017

OCA — Thu, 27 Apr 2017 13:53:15 GMT

←Older revision		Revision as of 13:53, 27 April 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5uj4 is ~~ON HOLD~~	+	==Crystal structure of the KPC-2 beta-lactamase complexed with hydrolyzed faropenem==
		+	<StructureSection load='5uj4' size='340' side='right' caption='[[5uj4]], [[Resolution\|resolution]] 1.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5uj4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UJ4 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SFR:(2R)-2-[(1S,2R)-1-CARBOXY-2-HYDROXYPROPYL]-5-[(2R)-OXOLAN-2-YL]-2,3-DIHYDRO-1,3-THIAZOLE-4-CARBOXYLIC+ACID'>SFR</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5uj3\|5uj3]], [[5ul8\|5ul8]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uj4 OCA], [http://pdbe.org/5uj4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uj4 RCSB], [http://www.ebi.ac.uk/pdbsum/5uj4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uj4 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BLKPC_KLEPN BLKPC_KLEPN]] Hydrolyzes carbapenems, penicillins, cephalosporins and monobactams with varying efficiency.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Carbapenem-resistant Enterobacteriaceae are resistant to most beta-lactam antibiotics due to the production of the Klebsiella pneumoniae carbapenemase (KPC-2) class A beta-lactamase. Here, we present the first product complex crystal structures of KPC-2 with beta-lactam antibiotics containing hydrolyzed cefotaxime and faropenem. They provide experimental insights into substrate recognition by KPC-2 and its unique cephalosporinase/carbapenemase activity. These structures also represent the first product complexes for a wild-type serine beta-lactamase, elucidating the product release mechanism of these enzymes in general.

-	~~Authors~~:	+	Molecular Basis of Substrate Recognition and Product Release by the Klebsiella pneumoniae Carbapenemase (KPC-2).,Pemberton OA, Zhang X, Chen Y J Med Chem. 2017 Apr 17. doi: 10.1021/acs.jmedchem.7b00158. PMID:28388065<ref>PMID:28388065</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5uj4" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Beta-lactamase]]
		+	[[Category: Chen, Y]]
		+	[[Category: Pemberton, O A]]
		+	[[Category: Carbapenemase]]
		+	[[Category: Complex]]
		+	[[Category: Faropenem]]
		+	[[Category: Hydrolase-antibiotic complex]]

OCA: Protected "5uj4" [edit=sysop:move=sysop]

OCA — Wed, 25 Jan 2017 22:12:25 GMT

Protected "5uj4" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:12, 25 January 2017

OCA: New page: '''Unreleased structure''' The entry 5uj4 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 25 Jan 2017 22:12:23 GMT

New page: '''Unreleased structure''' The entry 5uj4 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5uj4 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]