5ukq - Revision history

OCA at 13:29, 4 October 2023

OCA — Wed, 04 Oct 2023 13:29:08 GMT

←Older revision		Revision as of 13:29, 4 October 2023
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	<StructureSection load='5ukq' size='340' side='right'caption='[[5ukq]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='5ukq' size='340' side='right'caption='[[5ukq]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ukq]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Macmu Macmu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UKQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5UKQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ukq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UKQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UKQ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=GOL:GLYCEROL'>GOL</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5uko\|5uko]], [[5ukp\|5ukp]], [[5ukn\|5ukn]], [[5ukr\|5ukr]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ukq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ukq OCA], [~~http~~://pdbe.org/5ukq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ukq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ukq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ukq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ukq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ukq OCA], [https://pdbe.org/5ukq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ukq RCSB], [https://www.ebi.ac.uk/pdbsum/5ukq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ukq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Macmu~~]]	+	[[Category: Macaca mulatta]]
-	[[Category: Nicely~~, N I]]~~	+	[[Category: Nicely NI]]
-	~~[[Category: Hiv gp120 immune system]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 17:09, 11 December 2019

OCA — Wed, 11 Dec 2019 17:09:17 GMT

←Older revision		Revision as of 17:09, 11 December 2019
Line 1:		Line 1:

	==Structure of unliganded anti-gp120 CD4bs antibody DH522.2 Fab==		==Structure of unliganded anti-gp120 CD4bs antibody DH522.2 Fab==
-	<StructureSection load='5ukq' size='340' side='right' caption='[[5ukq]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='5ukq' size='340' side='right'caption='[[5ukq]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ukq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UKQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ukq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UKQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5uko\|5uko]], [[5ukp\|5ukp]], [[5ukn\|5ukn]], [[5ukr\|5ukr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5uko\|5uko]], [[5ukp\|5ukp]], [[5ukn\|5ukn]], [[5ukr\|5ukr]]</td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Macmu]]
	[[Category: Nicely, N I]]		[[Category: Nicely, N I]]
	[[Category: Hiv gp120 immune system]]		[[Category: Hiv gp120 immune system]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 07:14, 6 December 2017

OCA — Wed, 06 Dec 2017 07:14:29 GMT

←Older revision		Revision as of 07:14, 6 December 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5ukq is ~~ON HOLD until Paper~~ Publication	+	==Structure of unliganded anti-gp120 CD4bs antibody DH522.2 Fab==
		+	<StructureSection load='5ukq' size='340' side='right' caption='[[5ukq]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ukq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UKQ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5uko\|5uko]], [[5ukp\|5ukp]], [[5ukn\|5ukn]], [[5ukr\|5ukr]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ukq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ukq OCA], [http://pdbe.org/5ukq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ukq RCSB], [http://www.ebi.ac.uk/pdbsum/5ukq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ukq ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A strategy for HIV-1 vaccine development is to define envelope (Env) evolution of broadly neutralizing antibodies (bnAbs) in infection and to recreate those events by vaccination. Here, we report host tolerance mechanisms that limit the development of CD4-binding site (CD4bs), HCDR3-binder bnAbs via sequential HIV-1 Env vaccination. Vaccine-induced macaque CD4bs antibodies neutralize 7% of HIV-1 strains, recognize open Env trimers, and accumulate relatively modest somatic mutations. In naive CD4bs, unmutated common ancestor knock-in mice Env(+)B cell clones develop anergy and partial deletion at the transitional to mature B cell stage, but become Env(-) upon receptor editing. In comparison with repetitive Env immunizations, sequential Env administration rescue anergic Env(+) (non-edited) precursor B cells. Thus, stepwise immunization initiates CD4bs-bnAb responses, but immune tolerance mechanisms restrict their development, suggesting that sequential immunogen-based vaccine regimens will likely need to incorporate strategies to expand bnAb precursor pools.

-	~~Authors:~~ Nicely, N.I.	+	Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations.,Williams WB, Zhang J, Jiang C, Nicely NI, Fera D, Luo K, Moody MA, Liao HX, Alam SM, Kepler TB, Ramesh A, Wiehe K, Holland JA, Bradley T, Vandergrift N, Saunders KO, Parks R, Foulger A, Xia SM, Bonsignori M, Montefiori DC, Louder M, Eaton A, Santra S, Scearce R, Sutherland L, Newman A, Bouton-Verville H, Bowman C, Bomze H, Gao F, Marshall DJ, Whitesides JF, Nie X, Kelsoe G, Reed SG, Fox CB, Clary K, Koutsoukos M, Franco D, Mascola JR, Harrison SC, Haynes BF, Verkoczy L Nat Commun. 2017 Nov 23;8(1):1732. doi: 10.1038/s41467-017-01336-3. PMID:29170366<ref>PMID:29170366</ref>

-	~~Description: Structure~~ of ~~unliganded anti-gp120 CD4bs antibody DH522~~.~~2 Fab~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Nicely, N.I~~]]	+	<div class="pdbe-citations 5ukq" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Nicely, N I]]
		+	[[Category: Hiv gp120 immune system]]
		+	[[Category: Immune system]]

OCA at 14:33, 9 March 2017

OCA — Thu, 09 Mar 2017 14:33:41 GMT

←Older revision		Revision as of 14:33, 9 March 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ukq is ON HOLD	+	The entry 5ukq is ON HOLD until Paper Publication

	Authors: Nicely, N.I.		Authors: Nicely, N.I.

OCA: Protected "5ukq" [edit=sysop:move=sysop]

OCA — Wed, 01 Feb 2017 16:44:31 GMT

Protected "5ukq" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:44, 1 February 2017

OCA: New page: '''Unreleased structure''' The entry 5ukq is ON HOLD Authors: Nicely, N.I. Description: Structure of unliganded anti-gp120 CD4bs antibody DH522.2 Fab [[Category: Unreleased Structures]...

OCA — Wed, 01 Feb 2017 16:44:30 GMT

New page: '''Unreleased structure''' The entry 5ukq is ON HOLD Authors: Nicely, N.I. Description: Structure of unliganded anti-gp120 CD4bs antibody DH522.2 Fab [[Category: Unreleased Structures]...

New page

'''Unreleased structure'''

The entry 5ukq is ON HOLD

Authors: Nicely, N.I.

Description: Structure of unliganded anti-gp120 CD4bs antibody DH522.2 Fab
[[Category: Unreleased Structures]]
[[Category: Nicely, N.I]]