5unq - Revision history

OCA at 13:30, 4 October 2023

OCA — Wed, 04 Oct 2023 13:30:59 GMT

←Older revision		Revision as of 13:30, 4 October 2023
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	<StructureSection load='5unq' size='340' side='right'caption='[[5unq]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='5unq' size='340' side='right'caption='[[5unq]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5unq]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pusst Pusst~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UNQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5UNQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5unq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Pusillimonas_sp._T7-7 Pusillimonas sp. T7-7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UNQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UNQ FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=DYJ:'>DYJ</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.976Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PT7_0534 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=1007105 PUSST]~~)</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DYJ:1-[(2E)-4-carboxy-4-oxobut-2-en-2-yl]-L-proline'>DYJ</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5unq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5unq OCA], [~~http~~://pdbe.org/5unq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5unq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5unq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5unq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5unq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5unq OCA], [https://pdbe.org/5unq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5unq RCSB], [https://www.ebi.ac.uk/pdbsum/5unq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5unq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/F4GMX9_PUSST F4GMX9_PUSST]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pusst~~]]	+	[[Category: Pusillimonas sp. T7-7]]
-	[[Category: Baas~~, B J~~]]	+	[[Category: Baas BJ]]
-	[[Category: LeVieux, J]]	+	[[Category: LeVieux J]]
-	[[Category: Whitman~~, C P~~]]	+	[[Category: Whitman CP]]
-	[[Category: Zhang~~, Y J]]~~	+	[[Category: Zhang YJ]]
-	~~[[Category: 4-oxalocrotonate tautomerase]]~~	+
-	~~[[Category: Ciscaad]]~~	+
-	~~[[Category: Dehalogenase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Mif~~]]	+

OCA at 09:19, 1 January 2020

OCA — Wed, 01 Jan 2020 09:19:43 GMT

←Older revision		Revision as of 09:19, 1 January 2020
Line 1:		Line 1:

	==Crystal Structure of Pt0534 Inactivated by 2-Oxo-3-pentynoate==		==Crystal Structure of Pt0534 Inactivated by 2-Oxo-3-pentynoate==
-	<StructureSection load='5unq' size='340' side='right' caption='[[5unq]], [[Resolution\|resolution]] 1.98Å' scene=''>	+	<StructureSection load='5unq' size='340' side='right'caption='[[5unq]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5unq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Pusst Pusst]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UNQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UNQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[5unq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Pusst Pusst]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UNQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UNQ FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Pusst]]		[[Category: Pusst]]
	[[Category: Baas, B J]]		[[Category: Baas, B J]]

OCA at 06:58, 5 December 2018

OCA — Wed, 05 Dec 2018 06:58:42 GMT

←Older revision		Revision as of 06:58, 5 December 2018
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5unq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5unq OCA], [http://pdbe.org/5unq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5unq RCSB], [http://www.ebi.ac.uk/pdbsum/5unq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5unq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5unq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5unq OCA], [http://pdbe.org/5unq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5unq RCSB], [http://www.ebi.ac.uk/pdbsum/5unq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5unq ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The tautomerase superfamily (TSF) consists of more than 11,000 non-redundant sequences present throughout the biosphere. Characterized members have attracted much attention because of the unusual and key catalytic role of an N-terminal proline. These few characterized members catalyze a diverse range of chemical reactions, but the full scale of their chemical capabilities and biological functions remains unknown. To gain new insight into TSF structure-function relationships, we performed a global analysis of similarities across the entire superfamily and computed a sequence-similarity network to guide classification into distinct subgroups. Our results indicated that TSF members are found in all domains of life, with most being present in bacteria. The eukaryotic members of the cis-3- chloroacrylic acid dehalogenase subgroup are limited to fungal species, while the macrophagemigration inhibitory factor subgroup has wide eukaryotic representation (including mammals). Unexpectedly, we found that 346 TSF sequences lack Pro-1, of which 85% are present in the malonate semialdehyde decarboxylase subgroup. The computed network also enabled identification of similarity paths, namely sequences that link functionally diverse subgroups and exhibit transitional structural features that may help explain reaction divergence. A structure-guided comparison of these linker proteins identified conserved transitions between them, and kinetic analysis paralleled these observations. Phylogenetic reconstruction of the linker set was consistent with these findings. Our results also suggest that contemporary TSF members may have evolved from a short 4-oxalocrotonate tautomerase-like ancestor, followed by gene duplication and fusion. Our new linker-guided strategy can be used to enrich discovery of sequence/structure/function transitions in other enzyme superfamilies.
		+
		+	A global view of structure-function relationships in the tautomerase superfamily.,Davidson R, Baas BJ, Akiva E, Holliday GL, Polacco BJ, LeVieux JA, Pullara CR, Zhang YJ, Whitman CP, Babbitt PC J Biol Chem. 2017 Nov 28. pii: M117.815340. doi: 10.1074/jbc.M117.815340. PMID:29184004<ref>PMID:29184004</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5unq" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:47, 6 December 2017

OCA — Wed, 06 Dec 2017 07:47:33 GMT

←Older revision		Revision as of 07:47, 6 December 2017
Line 3:		Line 3:
	<StructureSection load='5unq' size='340' side='right' caption='[[5unq]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='5unq' size='340' side='right' caption='[[5unq]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5unq]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UNQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UNQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5unq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Pusst Pusst]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UNQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UNQ FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DYJ:'>DYJ</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DYJ:'>DYJ</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PT7_0534 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1007105 PUSST])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5unq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5unq OCA], [http://pdbe.org/5unq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5unq RCSB], [http://www.ebi.ac.uk/pdbsum/5unq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5unq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5unq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5unq OCA], [http://pdbe.org/5unq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5unq RCSB], [http://www.ebi.ac.uk/pdbsum/5unq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5unq ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Pusst]]
	[[Category: Baas, B J]]		[[Category: Baas, B J]]
	[[Category: LeVieux, J]]		[[Category: LeVieux, J]]

OCA at 07:42, 22 November 2017

OCA — Wed, 22 Nov 2017 07:42:39 GMT

←Older revision		Revision as of 07:42, 22 November 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5unq is ~~ON HOLD~~	+	==Crystal Structure of Pt0534 Inactivated by 2-Oxo-3-pentynoate==
-		+	<StructureSection load='5unq' size='340' side='right' caption='[[5unq]], [[Resolution\|resolution]] 1.98Å' scene=''>
-	~~Authors~~: ~~LeVieux~~, J., ~~Baas~~, B.J., ~~Zhang, Y~~.J., ~~Whitman, C~~.P.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5unq]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UNQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UNQ FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure of Pt0534 Inactivated by 2-Oxo-3-pentynoate~~	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DYJ:'>DYJ</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5unq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5unq OCA], [http://pdbe.org/5unq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5unq RCSB], [http://www.ebi.ac.uk/pdbsum/5unq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5unq ProSAT]</span></td></tr>
-	[[Category: Whitman, C.P]]	+	</table>
-	[[Category: Zhang, Y.J]]	+	__TOC__
-	[[Category: ~~Baas, B.J~~]]	+	</StructureSection>
-	[[Category: ~~Levieux, J~~]]	+	[[Category: Baas, B J]]
		+	[[Category: LeVieux, J]]
		+	[[Category: Whitman, C P]]
		+	[[Category: Zhang, Y J]]
		+	[[Category: 4-oxalocrotonate tautomerase]]
		+	[[Category: Ciscaad]]
		+	[[Category: Dehalogenase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Mif]]

OCA at 13:45, 27 September 2017

OCA — Wed, 27 Sep 2017 13:45:15 GMT

←Older revision		Revision as of 13:45, 27 September 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5unq is ON HOLD ~~until Paper Publication~~	+	The entry 5unq is ON HOLD

	Authors: LeVieux, J., Baas, B.J., Zhang, Y.J., Whitman, C.P.		Authors: LeVieux, J., Baas, B.J., Zhang, Y.J., Whitman, C.P.
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	Description: Crystal Structure of Pt0534 Inactivated by 2-Oxo-3-pentynoate		Description: Crystal Structure of Pt0534 Inactivated by 2-Oxo-3-pentynoate
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Whitman, C.P]]
	[[Category: Zhang, Y.J]]		[[Category: Zhang, Y.J]]
	[[Category: Baas, B.J]]		[[Category: Baas, B.J]]
-	[[Category: Whitman, C.P]]
	[[Category: Levieux, J]]		[[Category: Levieux, J]]

OCA at 19:13, 15 March 2017

OCA — Wed, 15 Mar 2017 19:13:20 GMT

←Older revision		Revision as of 19:13, 15 March 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5unq is ON HOLD	+	The entry 5unq is ON HOLD until Paper Publication

	Authors: LeVieux, J., Baas, B.J., Zhang, Y.J., Whitman, C.P.		Authors: LeVieux, J., Baas, B.J., Zhang, Y.J., Whitman, C.P.
Line 7:		Line 7:
	Description: Crystal Structure of Pt0534 Inactivated by 2-Oxo-3-pentynoate		Description: Crystal Structure of Pt0534 Inactivated by 2-Oxo-3-pentynoate
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Whitman, C.P]]
	[[Category: Zhang, Y.J]]		[[Category: Zhang, Y.J]]
	[[Category: Baas, B.J]]		[[Category: Baas, B.J]]
		+	[[Category: Whitman, C.P]]
	[[Category: Levieux, J]]		[[Category: Levieux, J]]

OCA: Protected "5unq" [edit=sysop:move=sysop]

OCA — Thu, 09 Mar 2017 14:39:33 GMT

Protected "5unq" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:39, 9 March 2017

OCA: New page: '''Unreleased structure''' The entry 5unq is ON HOLD Authors: LeVieux, J., Baas, B.J., Zhang, Y.J., Whitman, C.P. Description: Crystal Structure of Pt0534 Inactivated by 2-Oxo-3-pentyn...

OCA — Thu, 09 Mar 2017 14:39:30 GMT

New page: '''Unreleased structure''' The entry 5unq is ON HOLD Authors: LeVieux, J., Baas, B.J., Zhang, Y.J., Whitman, C.P. Description: Crystal Structure of Pt0534 Inactivated by 2-Oxo-3-pentyn...

New page

'''Unreleased structure'''

The entry 5unq is ON HOLD

Authors: LeVieux, J., Baas, B.J., Zhang, Y.J., Whitman, C.P.

Description: Crystal Structure of Pt0534 Inactivated by 2-Oxo-3-pentynoate
[[Category: Unreleased Structures]]
[[Category: Whitman, C.P]]
[[Category: Zhang, Y.J]]
[[Category: Baas, B.J]]
[[Category: Levieux, J]]