5uwa - Revision history

OCA at 13:36, 4 October 2023

OCA — Wed, 04 Oct 2023 13:36:03 GMT

←Older revision		Revision as of 13:36, 4 October 2023
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	<StructureSection load='5uwa' size='340' side='right'caption='[[5uwa]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='5uwa' size='340' side='right'caption='[[5uwa]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5uwa]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UWA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5UWA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5uwa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UWA FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=8ND:(2S)-3-(2-AMINOETHOXY)PROPANE-1,2-DIYL+DIHEXADECANOATE'>8ND</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.501Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5uvn\|5uvn]]~~, [[~~5uw2~~\|~~5uw2]], [[5uw8\|5uw8~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8ND:(2S)-3-(2-AMINOETHOXY)PROPANE-1,2-DIYL+DIHEXADECANOATE'>8ND</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~mlaC, yrbC, b3192, JW3159 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=83333 ECOLI]~~)</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uwa OCA], [https://pdbe.org/5uwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uwa RCSB], [https://www.ebi.ac.uk/pdbsum/5uwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uwa ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5uwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uwa OCA], [~~http~~://pdbe.org/5uwa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5uwa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5uwa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5uwa ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MLAC_ECOLI MLAC_ECOLI]] Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. May transfer phospholipid across the periplasmic space and deliver it to the MlaFEDB complex at the inner membrane.<ref>PMID:19383799</ref>	+	[https://www.uniprot.org/uniprot/MLAC_ECOLI MLAC_ECOLI] Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. May transfer phospholipid across the periplasmic space and deliver it to the MlaFEDB complex at the inner membrane.<ref>PMID:19383799</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli~~]]	+	[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bhabha, G]]	+	[[Category: Bhabha G]]
-	[[Category: Ekiert~~, D C]]~~	+	[[Category: Ekiert DC]]
-	~~[[Category: Bacterial lipid transport]]~~	+
-	~~[[Category: Phospholipid-binding protein]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 16:44, 20 November 2019

OCA — Wed, 20 Nov 2019 16:44:23 GMT

←Older revision		Revision as of 16:44, 20 November 2019
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	==Structure of E. coli phospholipid binding protein MlaC==		==Structure of E. coli phospholipid binding protein MlaC==
-	<StructureSection load='5uwa' size='340' side='right' caption='[[5uwa]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='5uwa' size='340' side='right'caption='[[5uwa]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5uwa]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UWA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5uwa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UWA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8ND:(2S)-3-(2-AMINOETHOXY)PROPANE-1,2-DIYL+DIHEXADECANOATE'>8ND</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8ND:(2S)-3-(2-AMINOETHOXY)PROPANE-1,2-DIYL+DIHEXADECANOATE'>8ND</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5uvn\|5uvn]], [[5uw2\|5uw2]], [[5uw8\|5uw8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5uvn\|5uvn]], [[5uw2\|5uw2]], [[5uw8\|5uw8]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mlaC, yrbC, b3192, JW3159 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uwa OCA], [http://pdbe.org/5uwa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uwa RCSB], [http://www.ebi.ac.uk/pdbsum/5uwa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uwa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uwa OCA], [http://pdbe.org/5uwa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uwa RCSB], [http://www.ebi.ac.uk/pdbsum/5uwa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uwa ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Ecoli]]
		+	[[Category: Large Structures]]
	[[Category: Bhabha, G]]		[[Category: Bhabha, G]]
	[[Category: Ekiert, D C]]		[[Category: Ekiert, D C]]

OCA at 06:18, 19 April 2017

OCA — Wed, 19 Apr 2017 06:18:40 GMT

←Older revision		Revision as of 06:18, 19 April 2017
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/MLAC_ECOLI MLAC_ECOLI]] Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. May transfer phospholipid across the periplasmic space and deliver it to the MlaFEDB complex at the inner membrane.<ref>PMID:19383799</ref>		[[http://www.uniprot.org/uniprot/MLAC_ECOLI MLAC_ECOLI]] Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. May transfer phospholipid across the periplasmic space and deliver it to the MlaFEDB complex at the inner membrane.<ref>PMID:19383799</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	How phospholipids are trafficked between the bacterial inner and outer membranes through the hydrophilic space of the periplasm is not known. We report that members of the mammalian cell entry (MCE) protein family form hexameric assemblies with a central channel capable of mediating lipid transport. The E. coli MCE protein, MlaD, forms a ring associated with an ABC transporter complex in the inner membrane. A soluble lipid-binding protein, MlaC, ferries lipids between MlaD and an outer membrane protein complex. In contrast, EM structures of two other E. coli MCE proteins show that YebT forms an elongated tube consisting of seven stacked MCE rings, and PqiB adopts a syringe-like architecture. Both YebT and PqiB create channels of sufficient length to span the periplasmic space. This work reveals diverse architectures of highly conserved protein-based channels implicated in the transport of lipids between the membranes of bacteria and some eukaryotic organelles.
		+
		+	Architectures of Lipid Transport Systems for the Bacterial Outer Membrane.,Ekiert DC, Bhabha G, Isom GL, Greenan G, Ovchinnikov S, Henderson IR, Cox JS, Vale RD Cell. 2017 Apr 6;169(2):273-285.e17. doi: 10.1016/j.cell.2017.03.019. PMID:28388411<ref>PMID:28388411</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5uwa" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:49, 12 April 2017

OCA — Wed, 12 Apr 2017 11:49:00 GMT

←Older revision		Revision as of 11:49, 12 April 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5uwa is ~~ON HOLD~~	+	==Structure of E. coli phospholipid binding protein MlaC==
-		+	<StructureSection load='5uwa' size='340' side='right' caption='[[5uwa]], [[Resolution\|resolution]] 1.50Å' scene=''>
-	~~Authors~~: ~~Bhabha~~, G., ~~Ekiert, D~~.C.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5uwa]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UWA FirstGlance]. <br>
-	~~Description~~: ~~Structure of E~~. ~~coli phospholipid binding protein MlaC~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8ND:(2S)-3-(2-AMINOETHOXY)PROPANE-1,2-DIYL+DIHEXADECANOATE'>8ND</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5uvn\|5uvn]], [[5uw2\|5uw2]], [[5uw8\|5uw8]]</td></tr>
-	[[~~Category~~: ~~Ekiert, D~~.C]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uwa OCA], [http://pdbe.org/5uwa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uwa RCSB], [http://www.ebi.ac.uk/pdbsum/5uwa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uwa ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MLAC_ECOLI MLAC_ECOLI]] Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. May transfer phospholipid across the periplasmic space and deliver it to the MlaFEDB complex at the inner membrane.<ref>PMID:19383799</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bhabha, G]]		[[Category: Bhabha, G]]
		+	[[Category: Ekiert, D C]]
		+	[[Category: Bacterial lipid transport]]
		+	[[Category: Phospholipid-binding protein]]
		+	[[Category: Transport protein]]

OCA: Protected "5uwa" [edit=sysop:move=sysop]

OCA — Thu, 09 Mar 2017 15:01:05 GMT

Protected "5uwa" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:01, 9 March 2017

OCA: New page: '''Unreleased structure''' The entry 5uwa is ON HOLD Authors: Bhabha, G., Ekiert, D.C. Description: Structure of E. coli phospholipid binding protein MlaC [[Category: Unreleased Struct...

OCA — Thu, 09 Mar 2017 15:01:04 GMT

New page: '''Unreleased structure''' The entry 5uwa is ON HOLD Authors: Bhabha, G., Ekiert, D.C. Description: Structure of E. coli phospholipid binding protein MlaC [[Category: Unreleased Struct...

New page

'''Unreleased structure'''

The entry 5uwa is ON HOLD

Authors: Bhabha, G., Ekiert, D.C.

Description: Structure of E. coli phospholipid binding protein MlaC
[[Category: Unreleased Structures]]
[[Category: Ekiert, D.C]]
[[Category: Bhabha, G]]