5uwc - Revision history

OCA at 13:36, 4 October 2023

OCA — Wed, 04 Oct 2023 13:36:04 GMT

←Older revision		Revision as of 13:36, 4 October 2023
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	<StructureSection load='5uwc' size='340' side='right'caption='[[5uwc]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5uwc' size='340' side='right'caption='[[5uwc]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5uwc]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UWC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5UWC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5uwc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UWC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EDT:{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC+ACID'>EDT</scene>, <scene name='pdbligand=~~IMD~~:~~IMIDAZOLE~~'>~~IMD~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL-D-GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~FUL~~:~~BETA~~-L-~~FUCOSE~~'>~~FUL~~</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5uv8\|5uv8]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EDT:{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC+ACID'>EDT</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IL3RA, IL3R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IL3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uwc OCA], [https://pdbe.org/5uwc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uwc RCSB], [https://www.ebi.ac.uk/pdbsum/5uwc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uwc ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5uwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uwc OCA], [~~http~~://pdbe.org/5uwc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5uwc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5uwc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5uwc ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/IL3RA_HUMAN IL3RA_HUMAN]] This is a receptor for interleukin-3. [[http://www.uniprot.org/uniprot/IL3_HUMAN IL3_HUMAN]] Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.	+	[https://www.uniprot.org/uniprot/IL3RA_HUMAN IL3RA_HUMAN] This is a receptor for interleukin-3.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Broughton~~, S E~~]]	+	[[Category: Broughton SE]]
-	[[Category: Parker~~, M W]]~~	+	[[Category: Parker MW]]
-	~~[[Category: Cytokine]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Signalling~~]]	+

OCA at 08:25, 30 September 2020

OCA — Wed, 30 Sep 2020 08:25:29 GMT

←Older revision		Revision as of 08:25, 30 September 2020
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	==Cytokine-receptor complex==		==Cytokine-receptor complex==
-	<StructureSection load='5uwc' size='340' side='right' caption='[[5uwc]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='5uwc' size='340' side='right'caption='[[5uwc]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5uwc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UWC OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5UWC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5uwc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UWC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5UWC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EDT:{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC+ACID'>EDT</scene>, <scene name='pdbligand=~~FUL~~:~~BETA-L-FUCOSE~~'>~~FUL~~</scene>, <scene name='pdbligand=~~IMD~~:~~IMIDAZOLE~~'>~~IMD~~</scene>, <scene name='pdbligand=~~NAG~~:N-~~ACETYL~~-~~D-GLUCOSAMINE~~'>~~NAG~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EDT:{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC+ACID'>EDT</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5uv8\|5uv8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5uv8\|5uv8]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5uwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uwc OCA], [http://pdbe.org/5uwc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uwc RCSB], [http://www.ebi.ac.uk/pdbsum/5uwc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uwc ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IL3RA, IL3R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IL3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5uwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uwc OCA], [http://pdbe.org/5uwc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uwc RCSB], [http://www.ebi.ac.uk/pdbsum/5uwc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uwc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5uwc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5uwc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Interleukin 3D structures\|Interleukin 3D structures]]
		+	*[[Interleukin receptor 3D structures\|Interleukin receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Broughton, S E]]		[[Category: Broughton, S E]]
	[[Category: Parker, M W]]		[[Category: Parker, M W]]

OCA at 06:13, 7 February 2018

OCA — Wed, 07 Feb 2018 06:13:21 GMT

←Older revision		Revision as of 06:13, 7 February 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5uwc is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Cytokine-receptor complex==
		+	<StructureSection load='5uwc' size='340' side='right' caption='[[5uwc]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5uwc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UWC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UWC FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EDT:{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC+ACID'>EDT</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5uv8\|5uv8]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uwc OCA], [http://pdbe.org/5uwc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uwc RCSB], [http://www.ebi.ac.uk/pdbsum/5uwc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uwc ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IL3RA_HUMAN IL3RA_HUMAN]] This is a receptor for interleukin-3. [[http://www.uniprot.org/uniprot/IL3_HUMAN IL3_HUMAN]] Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The interleukin-3 (IL-3) receptor is a cell-surface heterodimer that links the haemopoietic, vascular and immune systems and is overexpressed in acute and chronic myeloid leukaemia progenitor cells. It belongs to the type I cytokine receptor family in which the alpha-subunits consist of two fibronectin III-like domains that bind cytokine, and a third, evolutionarily unrelated and topologically conserved, N-terminal domain (NTD) with unknown function. Here we show by crystallography that, while the NTD of IL3Ralpha is highly mobile in the presence of IL-3, it becomes surprisingly rigid in the presence of IL-3 K116W. Mutagenesis, biochemical and functional studies show that the NTD of IL3Ralpha regulates IL-3 binding and signalling and reveal an unexpected role in preventing spontaneous receptor dimerisation. Our work identifies a dual role for the NTD in this cytokine receptor family, protecting against inappropriate signalling and dynamically regulating cytokine receptor binding and function.

-	~~Authors:~~ Broughton, ~~S.E.~~, ~~Parker~~, M.W.	+	A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.,Broughton SE, Hercus TR, Nero TL, Kan WL, Barry EF, Dottore M, Cheung Tung Shing KS, Morton CJ, Dhagat U, Hardy MP, Wilson NJ, Downton MT, Schieber C, Hughes TP, Lopez AF, Parker MW Nat Commun. 2018 Jan 26;9(1):386. doi: 10.1038/s41467-017-02633-7. PMID:29374162<ref>PMID:29374162</ref>

-	~~Description: Cytokine-receptor complex~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: Broughton, S.E]]	+	<div class="pdbe-citations 5uwc" style="background-color:#fffaf0;"></div>
-	[[Category: Parker, M.W]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Broughton, S E]]
		+	[[Category: Parker, M W]]
		+	[[Category: Cytokine]]
		+	[[Category: Receptor]]
		+	[[Category: Signaling protein]]
		+	[[Category: Signalling]]

OCA at 04:47, 20 December 2017

OCA — Wed, 20 Dec 2017 04:47:30 GMT

←Older revision		Revision as of 04:47, 20 December 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5uwc is ON HOLD	+	The entry 5uwc is ON HOLD until Paper Publication

	Authors: Broughton, S.E., Parker, M.W.		Authors: Broughton, S.E., Parker, M.W.

OCA: Protected "5uwc" [edit=sysop:move=sysop]

OCA — Thu, 09 Mar 2017 15:01:11 GMT

Protected "5uwc" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:01, 9 March 2017

OCA: New page: '''Unreleased structure''' The entry 5uwc is ON HOLD Authors: Broughton, S.E., Parker, M.W. Description: Cytokine-receptor complex Category: Unreleased Structures [[Category: Broug...

OCA — Thu, 09 Mar 2017 15:01:10 GMT

New page: '''Unreleased structure''' The entry 5uwc is ON HOLD Authors: Broughton, S.E., Parker, M.W. Description: Cytokine-receptor complex Category: Unreleased Structures [[Category: Broug...

New page

'''Unreleased structure'''

The entry 5uwc is ON HOLD

Authors: Broughton, S.E., Parker, M.W.

Description: Cytokine-receptor complex
[[Category: Unreleased Structures]]
[[Category: Broughton, S.E]]
[[Category: Parker, M.W]]