5v3m - Revision history

OCA at 08:29, 30 September 2020

OCA — Wed, 30 Sep 2020 08:29:58 GMT

←Older revision		Revision as of 08:29, 30 September 2020
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	==mouseZFP568-ZnF1-11 in complex with DNA==		==mouseZFP568-ZnF1-11 in complex with DNA==
-	<StructureSection load='5v3m' size='340' side='right' caption='[[5v3m]], [[Resolution\|resolution]] 2.09Å' scene=''>	+	<StructureSection load='5v3m' size='340' side='right'caption='[[5v3m]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5v3m]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V3M OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5V3M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5v3m]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V3M OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5V3M FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5v3g\|5v3g]], [[5v3j\|5v3j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5v3g\|5v3g]], [[5v3j\|5v3j]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5v3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v3m OCA], [http://pdbe.org/5v3m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v3m RCSB], [http://www.ebi.ac.uk/pdbsum/5v3m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v3m ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Znf568, chato, Zfp568 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5v3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v3m OCA], [http://pdbe.org/5v3m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v3m RCSB], [http://www.ebi.ac.uk/pdbsum/5v3m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v3m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/ZN568_MOUSE ZN568_MOUSE]] Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction (PubMed:22110054, PubMed:27658112). Essential during embryonic development, where it acts as direct repressor of IGF2-P0, placental-specific transcript of IGF2, in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers (PubMed:18701545, PubMed:22110054, PubMed:28522536). Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta (PubMed:18701545, PubMed:21094155). May enhance proliferation or maintenance of neural stem cells (PubMed:23071813).<ref>PMID:18701545</ref> <ref>PMID:21094155</ref> <ref>PMID:22110054</ref> <ref>PMID:23071813</ref> <ref>PMID:27658112</ref>		[[http://www.uniprot.org/uniprot/ZN568_MOUSE ZN568_MOUSE]] Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction (PubMed:22110054, PubMed:27658112). Essential during embryonic development, where it acts as direct repressor of IGF2-P0, placental-specific transcript of IGF2, in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers (PubMed:18701545, PubMed:22110054, PubMed:28522536). Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta (PubMed:18701545, PubMed:21094155). May enhance proliferation or maintenance of neural stem cells (PubMed:23071813).<ref>PMID:18701545</ref> <ref>PMID:21094155</ref> <ref>PMID:22110054</ref> <ref>PMID:23071813</ref> <ref>PMID:27658112</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tandem zinc finger (ZF) proteins are the largest and most rapidly diverging family of DNA-binding transcription regulators in mammals. ZFP568 represses a transcript of placental-specific insulin like growth factor 2 (Igf2-P0) in mice. ZFP568 binds a 24-base pair sequence-specific element upstream of Igf2-P0 via the eleven-ZF array. Both DNA and protein conformations deviate from the conventional one finger-three bases recognition, with individual ZFs contacting 2, 3, or 4 bases and recognizing thymine on the opposite strand. These interactions arise from a shortened minor groove caused by an AT-rich stretch, suggesting adaptability of ZF arrays to sequence variations. Despite conservation in mammals, mutations at Igf2 and ZFP568 reduce their binding affinity in chimpanzee and humans. Our studies provide important insights into the evolutionary and structural dynamics of ZF-DNA interactions that play a key role in mammalian development and evolution.
		+
		+	DNA Conformation Induces Adaptable Binding by Tandem Zinc Finger Proteins.,Patel A, Yang P, Tinkham M, Pradhan M, Sun MA, Wang Y, Hoang D, Wolf G, Horton JR, Zhang X, Macfarlan T, Cheng X Cell. 2018 Mar 22;173(1):221-233.e12. doi: 10.1016/j.cell.2018.02.058. Epub 2018 , Mar 15. PMID:29551271<ref>PMID:29551271</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5v3m" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Cheng, X]]		[[Category: Cheng, X]]
	[[Category: Patel, A]]		[[Category: Patel, A]]

OCA at 05:02, 8 March 2018

OCA — Thu, 08 Mar 2018 05:02:12 GMT

←Older revision		Revision as of 05:02, 8 March 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 5v3m is ~~ON HOLD~~ ~~until Paper Publication~~	+	==mouseZFP568-ZnF1-11 in complex with DNA==
-		+	<StructureSection load='5v3m' size='340' side='right' caption='[[5v3m]], [[Resolution\|resolution]] 2.09Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5v3m]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V3M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V3M FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5v3g\|5v3g]], [[5v3j\|5v3j]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v3m OCA], [http://pdbe.org/5v3m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v3m RCSB], [http://www.ebi.ac.uk/pdbsum/5v3m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v3m ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ZN568_MOUSE ZN568_MOUSE]] Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction (PubMed:22110054, PubMed:27658112). Essential during embryonic development, where it acts as direct repressor of IGF2-P0, placental-specific transcript of IGF2, in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers (PubMed:18701545, PubMed:22110054, PubMed:28522536). Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta (PubMed:18701545, PubMed:21094155). May enhance proliferation or maintenance of neural stem cells (PubMed:23071813).<ref>PMID:18701545</ref> <ref>PMID:21094155</ref> <ref>PMID:22110054</ref> <ref>PMID:23071813</ref> <ref>PMID:27658112</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Cheng, X]]
		+	[[Category: Patel, A]]
		+	[[Category: C2h2 type zinc finger]]
		+	[[Category: Dna binding]]
		+	[[Category: Dna binding protein-dna complex]]
		+	[[Category: Transferase-dna complex]]

OCA at 11:33, 5 April 2017

OCA — Wed, 05 Apr 2017 11:33:39 GMT

←Older revision		Revision as of 11:33, 5 April 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5v3m is ON HOLD	+	The entry 5v3m is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5v3m" [edit=sysop:move=sysop]

OCA — Wed, 15 Mar 2017 19:43:17 GMT

Protected "5v3m" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:43, 15 March 2017

OCA: New page: '''Unreleased structure''' The entry 5v3m is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 15 Mar 2017 19:43:16 GMT

New page: '''Unreleased structure''' The entry 5v3m is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5v3m is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]