5v5m - Revision history

OCA at 13:42, 4 October 2023

OCA — Wed, 04 Oct 2023 13:42:06 GMT

←Older revision		Revision as of 13:42, 4 October 2023
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	==Crystal structure of HLA-B*5701 complex with HIV-1 gag derived peptide TW10==		==Crystal structure of HLA-B*5701 complex with HIV-1 gag derived peptide TW10==
-	<StructureSection load='5v5m' size='340' side='right' caption='[[5v5m]], [[Resolution\|resolution]] 2.88Å' scene=''>	+	<StructureSection load='5v5m' size='340' side='right'caption='[[5v5m]], [[Resolution\|resolution]] 2.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5v5m]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human ~~Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V5M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5V5M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5v5m]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5V5M FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5v5l\|5v5l]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.878Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">HLA-B, HLAB ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5v5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v5m OCA], [https://pdbe.org/5v5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5v5m RCSB], [https://www.ebi.ac.uk/pdbsum/5v5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5v5m ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5v5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v5m OCA], [~~http~~://pdbe.org/5v5m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5v5m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5v5m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5v5m ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[~~http~~://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>	+	[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
	== Function ==		== Function ==
-	[~~[http://www.uniprot.org/uniprot/1B57_HUMAN 1B57_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http~~://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	+	[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Li, X~~]]	+	[[Category: Human immunodeficiency virus 1]]
-	[[Category: ~~Wang, J H~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Gag~~]]	+	[[Category: Li X]]
-	[[Category: ~~Hiv]]~~	+	[[Category: Wang J-H]]
-	~~[[Category: Hla]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Tw10~~]]	+

OCA at 10:05, 16 November 2017

OCA — Thu, 16 Nov 2017 10:05:04 GMT

←Older revision		Revision as of 10:05, 16 November 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5v5m is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of HLA-B*5701 complex with HIV-1 gag derived peptide TW10==
-		+	<StructureSection load='5v5m' size='340' side='right' caption='[[5v5m]], [[Resolution\|resolution]] 2.88Å' scene=''>
-	~~Authors~~: Li, X., ~~Wang~~, J.-H.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5v5m]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V5M FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of ~~HLA~~-~~B*5701 complex with HIV~~-~~1 gag derived~~ peptide ~~TW10~~	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5v5l\|5v5l]]</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA-B, HLAB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v5m OCA], [http://pdbe.org/5v5m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v5m RCSB], [http://www.ebi.ac.uk/pdbsum/5v5m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v5m ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/1B57_HUMAN 1B57_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
	[[Category: Li, X]]		[[Category: Li, X]]
-	[[Category: Wang, J.-H]]	+	[[Category: Wang, J H]]
		+	[[Category: Gag]]
		+	[[Category: Hiv]]
		+	[[Category: Hla]]
		+	[[Category: Immune system]]
		+	[[Category: Tw10]]

OCA at 11:06, 19 April 2017

OCA — Wed, 19 Apr 2017 11:06:48 GMT

←Older revision		Revision as of 11:06, 19 April 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5v5m is ON HOLD	+	The entry 5v5m is ON HOLD until Paper Publication

	Authors: Li, X., Wang, J.-H.		Authors: Li, X., Wang, J.-H.

OCA: Protected "5v5m" [edit=sysop:move=sysop]

OCA — Wed, 05 Apr 2017 11:37:49 GMT

Protected "5v5m" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:37, 5 April 2017

OCA: New page: '''Unreleased structure''' The entry 5v5m is ON HOLD Authors: Li, X., Wang, J.-H. Description: Crystal structure of HLA-B*5701 complex with HIV-1 gag derived peptide TW10 [[Category: U...

OCA — Wed, 05 Apr 2017 11:37:47 GMT

New page: '''Unreleased structure''' The entry 5v5m is ON HOLD Authors: Li, X., Wang, J.-H. Description: Crystal structure of HLA-B*5701 complex with HIV-1 gag derived peptide TW10 [[Category: U...

New page

'''Unreleased structure'''

The entry 5v5m is ON HOLD

Authors: Li, X., Wang, J.-H.

Description: Crystal structure of HLA-B*5701 complex with HIV-1 gag derived peptide TW10
[[Category: Unreleased Structures]]
[[Category: Li, X]]
[[Category: Wang, J.-H]]