5v5v - Revision history

OCA at 13:42, 4 October 2023

OCA — Wed, 04 Oct 2023 13:42:16 GMT

←Older revision		Revision as of 13:42, 4 October 2023
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	<StructureSection load='5v5v' size='340' side='right'caption='[[5v5v]], [[Resolution\|resolution]] 4.11Å' scene=''>		<StructureSection load='5v5v' size='340' side='right'caption='[[5v5v]], [[Resolution\|resolution]] 4.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5v5v]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V5V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5V5V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5v5v]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V5V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5V5V FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5v5w\|5v5w]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 4.11Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">Nlgn2 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10116 Buffalo rat]), MDGA1, MAMDC3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5v5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v5v OCA], [https://pdbe.org/5v5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5v5v RCSB], [https://www.ebi.ac.uk/pdbsum/5v5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5v5v ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5v5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v5v OCA], [~~http~~://pdbe.org/5v5v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5v5v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5v5v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5v5v ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NLGN2_RAT NLGN2_RAT]] Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion.<ref>PMID:19755106</ref> <ref>PMID:22528485</ref> [[http://www.uniprot.org/uniprot/MDGA1_HUMAN MDGA1_HUMAN]] Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2.<ref>PMID:23248271</ref>	+	[https://www.uniprot.org/uniprot/NLGN2_RAT NLGN2_RAT] Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion.<ref>PMID:19755106</ref> <ref>PMID:22528485</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Buffalo rat]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Gangwar, S P~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Machius, M~~]]	+	[[Category: Gangwar SP]]
-	[[Category: ~~Rudenko, G~~]]	+	[[Category: Machius M]]
-	[[Category: ~~Cell adhesion]]~~	+	[[Category: Rudenko G]]
-	~~[[Category: Mdga]]~~	+
-	~~[[Category: Neuroligin]]~~	+
-	~~[[Category: Regulatory complex]]~~	+
-	~~[[Category: Synaptic organizer~~]]	+

OCA at 08:02, 27 November 2019

OCA — Wed, 27 Nov 2019 08:02:52 GMT

←Older revision		Revision as of 08:02, 27 November 2019
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	==Complex of NLGN2 with MDGA1 Ig1-Ig2==		==Complex of NLGN2 with MDGA1 Ig1-Ig2==
-	<StructureSection load='5v5v' size='340' side='right' caption='[[5v5v]], [[Resolution\|resolution]] 4.11Å' scene=''>	+	<StructureSection load='5v5v' size='340' side='right'caption='[[5v5v]], [[Resolution\|resolution]] 4.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5v5v]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V5V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5v5v]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V5V FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5v5w\|5v5w]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5v5w\|5v5w]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Nlgn2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), MDGA1, MAMDC3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v5v OCA], [http://pdbe.org/5v5v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v5v RCSB], [http://www.ebi.ac.uk/pdbsum/5v5v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v5v ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v5v OCA], [http://pdbe.org/5v5v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v5v RCSB], [http://www.ebi.ac.uk/pdbsum/5v5v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v5v ProSAT]</span></td></tr>
	</table>		</table>
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	</div>		</div>
	<div class="pdbe-citations 5v5v" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5v5v" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Neuroligin\|Neuroligin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Gangwar, S P]]		[[Category: Gangwar, S P]]
	[[Category: Machius, M]]		[[Category: Machius, M]]

OCA at 14:39, 6 November 2017

OCA — Mon, 06 Nov 2017 14:39:23 GMT

←Older revision		Revision as of 14:39, 6 November 2017
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5v5v" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5v5v" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Neuroligin\|Neuroligin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:20, 27 September 2017

OCA — Wed, 27 Sep 2017 10:20:07 GMT

←Older revision		Revision as of 10:20, 27 September 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5v5v is ~~ON HOLD~~	+	==Complex of NLGN2 with MDGA1 Ig1-Ig2==
		+	<StructureSection load='5v5v' size='340' side='right' caption='[[5v5v]], [[Resolution\|resolution]] 4.11Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5v5v]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V5V FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5v5w\|5v5w]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v5v OCA], [http://pdbe.org/5v5v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v5v RCSB], [http://www.ebi.ac.uk/pdbsum/5v5v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v5v ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NLGN2_RAT NLGN2_RAT]] Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion.<ref>PMID:19755106</ref> <ref>PMID:22528485</ref> [[http://www.uniprot.org/uniprot/MDGA1_HUMAN MDGA1_HUMAN]] Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2.<ref>PMID:23248271</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Neuroligins and neurexins promote synapse development and validation by forming trans-synaptic bridges spanning the synaptic cleft. Select pairs promote excitatory and inhibitory synapses, with neuroligin 2 (NLGN2) limited to inhibitory synapses and neuroligin 1 (NLGN1) dominating at excitatory synapses. The cell-surface molecules, MAM domain-containing glycosylphosphatidylinositol anchor 1 (MDGA1) and 2 (MDGA2), regulate trans-synaptic adhesion between neurexins and neuroligins, impacting NLGN2 and NLGN1, respectively. We have determined the molecular mechanism of MDGA action. MDGA1 Ig1-Ig2 is sufficient to bind NLGN2 with nanomolar affinity; its crystal structure reveals an unusual locked rod-shaped array. In the crystal structure of the complex, two MDGA1 Ig1-Ig2 molecules each span the entire NLGN2 dimer. Site-directed mutagenesis confirms the observed interaction interface. Strikingly, Ig1 from MDGA1 binds to the same region on NLGN2 as neurexins do. Thus, MDGAs regulate the formation of neuroligin-neurexin trans-synaptic bridges by sterically blocking access of neurexins to neuroligins.

-	~~Authors~~:	+	Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin Trans-synaptic Bridges.,Gangwar SP, Zhong X, Seshadrinathan S, Chen H, Machius M, Rudenko G Neuron. 2017 Jun 21;94(6):1132-1141.e4. doi: 10.1016/j.neuron.2017.06.009. PMID:28641112<ref>PMID:28641112</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5v5v" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Neuroligin\|Neuroligin]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gangwar, S P]]
		+	[[Category: Machius, M]]
		+	[[Category: Rudenko, G]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Mdga]]
		+	[[Category: Neuroligin]]
		+	[[Category: Regulatory complex]]
		+	[[Category: Synaptic organizer]]

OCA: Protected "5v5v" [edit=sysop:move=sysop]

OCA — Wed, 05 Apr 2017 11:38:25 GMT

Protected "5v5v" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:38, 5 April 2017

OCA: New page: '''Unreleased structure''' The entry 5v5v is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 05 Apr 2017 11:38:24 GMT

New page: '''Unreleased structure''' The entry 5v5v is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5v5v is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]