5v6z - Revision history

OCA at 13:42, 4 October 2023

OCA — Wed, 04 Oct 2023 13:42:57 GMT

←Older revision		Revision as of 13:42, 4 October 2023
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	<StructureSection load='5v6z' size='340' side='right'caption='[[5v6z]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5v6z' size='340' side='right'caption='[[5v6z]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5v6z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V6Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5V6Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5v6z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5V6Z FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=8YJ:2~~-{[2~~-(4-chlorophenyl)-2-oxoethyl]sulfanyl}benzoic+acid'>8YJ</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5v6u\|5v6u]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8YJ:2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}benzoic+acid'>8YJ</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[http~~:~~//en.wikipedia.org/wiki/Caspase~~-~~7 Caspase-7], with EC number~~ [~~http://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=3.~~4~~.22.60 3.4.22.60~~] </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5v6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v6z OCA], [https://pdbe.org/5v6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5v6z RCSB], [https://www.ebi.ac.uk/pdbsum/5v6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5v6z ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5v6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v6z OCA], [~~http~~://pdbe.org/5v6z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5v6z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5v6z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5v6z ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Overexpression promotes programmed cell death.	+	[https://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Overexpression promotes programmed cell death.

	==See Also==		==See Also==
Line 16:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Caspase-7~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gakhar, L]]	+	[[Category: Gakhar L]]
-	[[Category: Spies~~, M A~~]]	+	[[Category: Spies MA]]
-	[[Category: Vance~~, N R]]~~	+	[[Category: Vance NR]]
-	~~[[Category: Allosteric]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Protease~~]]	+

OCA at 08:31, 30 September 2020

OCA — Wed, 30 Sep 2020 08:31:48 GMT

←Older revision		Revision as of 08:31, 30 September 2020
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	==Crystal structure of human caspase-7 soaked with allosteric inhibitor 2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}benzoic acid==		==Crystal structure of human caspase-7 soaked with allosteric inhibitor 2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}benzoic acid==
-	<StructureSection load='5v6z' size='340' side='right' caption='[[5v6z]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='5v6z' size='340' side='right'caption='[[5v6z]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5v6z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V6Z OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5V6Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5v6z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V6Z OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5V6Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8YJ:2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}benzoic+acid'>8YJ</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8YJ:2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}benzoic+acid'>8YJ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5v6u\|5v6u]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5v6u\|5v6u]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5v6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v6z OCA], [http://pdbe.org/5v6z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v6z RCSB], [http://www.ebi.ac.uk/pdbsum/5v6z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v6z ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5v6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v6z OCA], [http://pdbe.org/5v6z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v6z RCSB], [http://www.ebi.ac.uk/pdbsum/5v6z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v6z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Overexpression promotes programmed cell death.		[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Overexpression promotes programmed cell death.
		+
		+	==See Also==
		+	*[[Caspase 3D structures\|Caspase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Caspase-7]]		[[Category: Caspase-7]]
		+	[[Category: Large Structures]]
	[[Category: Gakhar, L]]		[[Category: Gakhar, L]]
	[[Category: Spies, M A]]		[[Category: Spies, M A]]

OCA at 07:32, 21 March 2018

OCA — Wed, 21 Mar 2018 07:32:24 GMT

←Older revision		Revision as of 07:32, 21 March 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 5v6z is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of human caspase-7 soaked with allosteric inhibitor 2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}benzoic acid==
-		+	<StructureSection load='5v6z' size='340' side='right' caption='[[5v6z]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5v6z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V6Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V6Z FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8YJ:2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}benzoic+acid'>8YJ</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5v6u\|5v6u]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v6z OCA], [http://pdbe.org/5v6z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v6z RCSB], [http://www.ebi.ac.uk/pdbsum/5v6z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v6z ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Overexpression promotes programmed cell death.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Caspase-7]]
		+	[[Category: Gakhar, L]]
		+	[[Category: Spies, M A]]
		+	[[Category: Vance, N R]]
		+	[[Category: Allosteric]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Inhibitor]]
		+	[[Category: Protease]]

OCA at 13:55, 27 September 2017

OCA — Wed, 27 Sep 2017 13:55:13 GMT

←Older revision		Revision as of 13:55, 27 September 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5v6z is ON HOLD	+	The entry 5v6z is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5v6z" [edit=sysop:move=sysop]

OCA — Wed, 05 Apr 2017 11:40:39 GMT

Protected "5v6z" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:40, 5 April 2017

OCA: New page: '''Unreleased structure''' The entry 5v6z is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 05 Apr 2017 11:40:38 GMT

New page: '''Unreleased structure''' The entry 5v6z is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5v6z is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]