5v7r - Revision history

OCA at 13:43, 4 October 2023

OCA — Wed, 04 Oct 2023 13:43:29 GMT

←Older revision		Revision as of 13:43, 4 October 2023
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	<StructureSection load='5v7r' size='340' side='right'caption='[[5v7r]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='5v7r' size='340' side='right'caption='[[5v7r]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5v7r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V7R OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5V7R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5v7r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5V7R FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">[[~~5v7u~~\|~~5v7u~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5v7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v7r OCA], [~~http~~://pdbe.org/5v7r PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5v7r RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5v7r PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5v7r ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5v7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v7r OCA], [https://pdbe.org/5v7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5v7r RCSB], [https://www.ebi.ac.uk/pdbsum/5v7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5v7r ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Wilson~~, I A~~]]	+	[[Category: Wilson IA]]
-	[[Category: Zhang, H]]	+	[[Category: Zhang H]]
-	[[Category: Zhu, X]]	+	[[Category: Zhu X]]
-	~~[[Category: Alzheimer's disease]]~~	+
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Fab]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Tau protein~~]]	+

OCA at 08:32, 30 September 2020

OCA — Wed, 30 Sep 2020 08:32:04 GMT

←Older revision		Revision as of 08:32, 30 September 2020
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	==Cyrstal structure of anti-Tau antibody CBTAU-7.1 Fab==		==Cyrstal structure of anti-Tau antibody CBTAU-7.1 Fab==
-	<StructureSection load='5v7r' size='340' side='right' caption='[[5v7r]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='5v7r' size='340' side='right'caption='[[5v7r]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5v7r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V7R OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5V7R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5v7r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V7R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5V7R FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5v7u\|5v7u]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5v7u\|5v7u]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5v7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v7r OCA], [http://pdbe.org/5v7r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v7r RCSB], [http://www.ebi.ac.uk/pdbsum/5v7r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v7r ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5v7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v7r OCA], [http://pdbe.org/5v7r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v7r RCSB], [http://www.ebi.ac.uk/pdbsum/5v7r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v7r ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Wilson, I A]]		[[Category: Wilson, I A]]
	[[Category: Zhang, H]]		[[Category: Zhang, H]]

OCA at 11:38, 12 April 2017

OCA — Wed, 12 Apr 2017 11:38:57 GMT

←Older revision		Revision as of 11:38, 12 April 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5v7r is ~~ON HOLD~~	+	==Cyrstal structure of anti-Tau antibody CBTAU-7.1 Fab==
		+	<StructureSection load='5v7r' size='340' side='right' caption='[[5v7r]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5v7r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V7R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V7R FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5v7u\|5v7u]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v7r OCA], [http://pdbe.org/5v7r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v7r RCSB], [http://www.ebi.ac.uk/pdbsum/5v7r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v7r ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Several reports have described the presence of antibodies against Alzheimer's disease-associated hyperphosphorylated forms of tau in serum of healthy individuals. To characterize the specificities that can be found, we interrogated peripheral IgG+ memory B cells from asymptomatic blood donors for reactivity to a panel of phosphorylated tau peptides using a single-cell screening assay. Antibody sequences were recovered, cloned, and expressed as full-length IgGs. In total, 52 somatically mutated tau-binding antibodies were identified, corresponding to 35 unique clonal families. Forty-one of these antibodies recognize epitopes in the proline-rich and C-terminal domains, and binding of 26 of these antibodies is strictly phosphorylation dependent. Thirteen antibodies showed inhibitory activity in a P301S lysate seeded in vitro tau aggregation assay. Two such antibodies, CBTAU-7.1 and CBTAU-22.1, which bind to the proline-rich and C-terminal regions of tau, respectively, were characterized in more detail. CBTAU-7.1 recognizes an epitope that is similar to that of murine anti-PHF antibody AT8, but has different phospho requirements. Both CBTAU-7.1 and CBTAU-22.1 detect pathological tau deposits in post-mortem brain tissue. CBTAU-7.1 reveals a similar IHC distribution pattern as AT8, immunostaining (pre)tangles, threads, and neuritic plaques. CBTAU-22.1 shows selective detection of neurofibrillary changes by IHC. Taken together, these results suggest the presence of an ongoing antigen-driven immune response against tau in healthy individuals. The wide range of specificities to tau suggests that the human immune repertoire may contain antibodies that can serve as biomarkers or be exploited for therapy.

-	~~Authors: Zhu~~, X., ~~Zhang~~, H., ~~Wilson~~, I.A.	+	Immunological memory to hyperphosphorylated tau in asymptomatic individuals.,Pascual G, Wadia JS, Zhu X, Keogh E, Kukrer B, van Ameijde J, Inganas H, Siregar B, Perdok G, Diefenbach O, Nahar T, Sprengers I, Koldijk MH, der Linden EC, Peferoen LA, Zhang H, Yu W, Li X, Wagner M, Moreno V, Kim J, Costa M, West K, Fulton Z, Chammas L, Luckashenak N, Fletcher L, Holland T, Arnold C, Anthony Williamson R, Hoozemans JJ, Apetri A, Bard F, Wilson IA, Koudstaal W, Goudsmit J Acta Neuropathol. 2017 Mar 24. doi: 10.1007/s00401-017-1705-y. PMID:28341999<ref>PMID:28341999</ref>

-	~~Description: Cyrstal structure~~ of ~~anti~~-~~Tau antibody CBTAU~~-~~7.1 Fab~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5v7r" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Wilson, I A]]
	[[Category: Zhang, H]]		[[Category: Zhang, H]]
-	[[Category: Wilson, I.A]]
	[[Category: Zhu, X]]		[[Category: Zhu, X]]
		+	[[Category: Alzheimer's disease]]
		+	[[Category: Antibody]]
		+	[[Category: Fab]]
		+	[[Category: Immune system]]
		+	[[Category: Tau protein]]

OCA: Protected "5v7r" [edit=sysop:move=sysop]

OCA — Wed, 05 Apr 2017 11:42:12 GMT

Protected "5v7r" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:42, 5 April 2017

OCA: New page: '''Unreleased structure''' The entry 5v7r is ON HOLD Authors: Zhu, X., Zhang, H., Wilson, I.A. Description: Cyrstal structure of anti-Tau antibody CBTAU-7.1 Fab [[Category: Unreleased ...

OCA — Wed, 05 Apr 2017 11:42:11 GMT

New page: '''Unreleased structure''' The entry 5v7r is ON HOLD Authors: Zhu, X., Zhang, H., Wilson, I.A. Description: Cyrstal structure of anti-Tau antibody CBTAU-7.1 Fab [[Category: Unreleased ...

New page

'''Unreleased structure'''

The entry 5v7r is ON HOLD

Authors: Zhu, X., Zhang, H., Wilson, I.A.

Description: Cyrstal structure of anti-Tau antibody CBTAU-7.1 Fab
[[Category: Unreleased Structures]]
[[Category: Zhang, H]]
[[Category: Wilson, I.A]]
[[Category: Zhu, X]]