5vax - Revision history

OCA at 13:45, 4 October 2023

OCA — Wed, 04 Oct 2023 13:45:07 GMT

←Older revision		Revision as of 13:45, 4 October 2023
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	<StructureSection load='5vax' size='340' side='right'caption='[[5vax]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5vax' size='340' side='right'caption='[[5vax]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5vax]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VAX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5VAX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5vax]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VAX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VAX FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5vau\|5vau]], [[5vay\|5vay]], [[5vb1\|5vb1]], [[5vb4\|5vb4]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5vax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vax OCA], [~~http~~://pdbe.org/5vax PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5vax RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5vax PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5vax ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vax OCA], [https://pdbe.org/5vax PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vax RCSB], [https://www.ebi.ac.uk/pdbsum/5vax PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vax ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.	+	[https://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref> [[http://www.uniprot.org/uniprot/BECN1_HUMAN BECN1_HUMAN]] Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.<ref>PMID:20208530</ref>	+	[https://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fairlie~~, W D~~]]	+	[[Category: Fairlie WD]]
-	[[Category: Lee~~, E F~~]]	+	[[Category: Lee EF]]
-	[[Category: Smith~~, B J~~]]	+	[[Category: Smith BJ]]
-	[[Category: Yao, S]]	+	[[Category: Yao S]]
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Autophagy]]~~	+
-	~~[[Category: Bcl-2]]~~	+
-	~~[[Category: Beclin 1~~]]	+

OCA at 08:33, 30 September 2020

OCA — Wed, 30 Sep 2020 08:33:52 GMT

←Older revision		Revision as of 08:33, 30 September 2020
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	==Bcl-2 complex with Beclin 1 BH3 domain==		==Bcl-2 complex with Beclin 1 BH3 domain==
-	<StructureSection load='5vax' size='340' side='right' caption='[[5vax]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='5vax' size='340' side='right'caption='[[5vax]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5vax]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VAX OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5VAX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5vax]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VAX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5VAX FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vau\|5vau]], [[5vay\|5vay]], [[5vb1\|5vb1]], [[5vb4\|5vb4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vau\|5vau]], [[5vay\|5vay]], [[5vb1\|5vb1]], [[5vb4\|5vb4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5vax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vax OCA], [http://pdbe.org/5vax PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vax RCSB], [http://www.ebi.ac.uk/pdbsum/5vax PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vax ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5vax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vax OCA], [http://pdbe.org/5vax PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vax RCSB], [http://www.ebi.ac.uk/pdbsum/5vax PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vax ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 16:		Line 16:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Fairlie, W D]]		[[Category: Fairlie, W D]]
	[[Category: Lee, E F]]		[[Category: Lee, E F]]

OCA at 05:53, 4 April 2018

OCA — Wed, 04 Apr 2018 05:53:01 GMT

←Older revision		Revision as of 05:53, 4 April 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5vax is ~~ON HOLD until Paper Publication~~	+	==Bcl-2 complex with Beclin 1 BH3 domain==
-		+	<StructureSection load='5vax' size='340' side='right' caption='[[5vax]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~Authors~~: ~~Lee~~, E.F., ~~Smith, B~~.J., ~~Yao~~, S., ~~Fairlie~~, W.D.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5vax]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VAX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VAX FirstGlance]. <br>
-	~~Description~~: ~~Bcl~~-~~2 complex~~ with ~~Beclin~~ 1 ~~BH3 domain~~	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vau\|5vau]], [[5vay\|5vay]], [[5vb1\|5vb1]], [[5vb4\|5vb4]]</td></tr>
-	[[Category: Fairlie, W.D]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vax OCA], [http://pdbe.org/5vax PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vax RCSB], [http://www.ebi.ac.uk/pdbsum/5vax PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vax ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref> [[http://www.uniprot.org/uniprot/BECN1_HUMAN BECN1_HUMAN]] Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.<ref>PMID:20208530</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Fairlie, W D]]
		+	[[Category: Lee, E F]]
		+	[[Category: Smith, B J]]
	[[Category: Yao, S]]		[[Category: Yao, S]]
-	[[Category: ~~Lee, E.F~~]]	+	[[Category: Apoptosis]]
-	[[Category: ~~Smith, B.J~~]]	+	[[Category: Autophagy]]
		+	[[Category: Bcl-2]]
		+	[[Category: Beclin 1]]

OCA at 06:23, 8 November 2017

OCA — Wed, 08 Nov 2017 06:23:06 GMT

←Older revision		Revision as of 06:23, 8 November 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5vax is ON HOLD	+	The entry 5vax is ON HOLD until Paper Publication

	Authors: Lee, E.F., Smith, B.J., Yao, S., Fairlie, W.D.		Authors: Lee, E.F., Smith, B.J., Yao, S., Fairlie, W.D.

OCA at 13:58, 27 September 2017

OCA — Wed, 27 Sep 2017 13:58:19 GMT

←Older revision		Revision as of 13:58, 27 September 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5vax is ON HOLD ~~until sometime in the future~~	+	The entry 5vax is ON HOLD

-	Authors: ~~Erinna~~ F.~~Lee~~, ~~Brian~~ J.~~Smith~~, ~~Shenggen~~ Yao, ~~Walter D~~.Fairlie	+	Authors: Lee, E.F., Smith, B.J., Yao, S., Fairlie, W.D.

	Description: Bcl-2 complex with Beclin 1 BH3 domain		Description: Bcl-2 complex with Beclin 1 BH3 domain
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Erinna F~~.Lee, ~~Brian J~~.Smith, ~~Shenggen Yao, Walter D~~.~~Fairlie~~]]	+	[[Category: Fairlie, W.D]]
		+	[[Category: Yao, S]]
		+	[[Category: Lee, E.F]]
		+	[[Category: Smith, B.J]]

OCA at 11:14, 19 April 2017

OCA — Wed, 19 Apr 2017 11:14:49 GMT

←Older revision		Revision as of 11:14, 19 April 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5vax is ON HOLD	+	The entry 5vax is ON HOLD until sometime in the future

	Authors: Erinna F.Lee, Brian J.Smith, Shenggen Yao, Walter D.Fairlie		Authors: Erinna F.Lee, Brian J.Smith, Shenggen Yao, Walter D.Fairlie

OCA at 09:48, 12 April 2017

OCA — Wed, 12 Apr 2017 09:48:04 GMT

←Older revision		Revision as of 09:48, 12 April 2017
Line 3:		Line 3:
	The entry 5vax is ON HOLD		The entry 5vax is ON HOLD

-	Authors: Erinna F.Lee, Brian J.Smith, Shenggen Yao, Walter D. Fairlie	+	Authors: Erinna F.Lee, Brian J.Smith, Shenggen Yao, Walter D.Fairlie

	Description: Bcl-2 complex with Beclin 1 BH3 domain		Description: Bcl-2 complex with Beclin 1 BH3 domain
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Erinna F.Lee, Brian J.Smith, Shenggen Yao, Walter D. Fairlie]]	+	[[Category: Erinna F.Lee, Brian J.Smith, Shenggen Yao, Walter D.Fairlie]]

OCA: Protected "5vax" [edit=sysop:move=sysop]

OCA — Wed, 05 Apr 2017 11:52:37 GMT

Protected "5vax" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:52, 5 April 2017

OCA: New page: '''Unreleased structure''' The entry 5vax is ON HOLD Authors: Erinna F.Lee, Brian J.Smith, Shenggen Yao, Walter D. Fairlie Description: Bcl-2 complex with Beclin 1 BH3 domain [[Categor...

OCA — Wed, 05 Apr 2017 11:52:36 GMT

New page: '''Unreleased structure''' The entry 5vax is ON HOLD Authors: Erinna F.Lee, Brian J.Smith, Shenggen Yao, Walter D. Fairlie Description: Bcl-2 complex with Beclin 1 BH3 domain [[Categor...

New page

'''Unreleased structure'''

The entry 5vax is ON HOLD

Authors: Erinna F.Lee, Brian J.Smith, Shenggen Yao, Walter D. Fairlie

Description: Bcl-2 complex with Beclin 1 BH3 domain
[[Category: Unreleased Structures]]
[[Category: Erinna F.Lee, Brian J.Smith, Shenggen Yao, Walter D. Fairlie]]