5vem - Revision history

OCA at 08:25, 8 January 2020

OCA — Wed, 08 Jan 2020 08:25:54 GMT

←Older revision		Revision as of 08:25, 8 January 2020
Line 1:		Line 1:

	==Human ectonucleotide pyrophosphatase / phosphodiesterase 5 (ENPP5, NPP5)==		==Human ectonucleotide pyrophosphatase / phosphodiesterase 5 (ENPP5, NPP5)==
-	<StructureSection load='5vem' size='340' side='right' caption='[[5vem]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='5vem' size='340' side='right'caption='[[5vem]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5vem]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VEM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VEM FirstGlance]. <br>		<table><tr><td colspan='2'>[[5vem]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VEM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VEM FirstGlance]. <br>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5vem" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5vem" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ectonucleotide pyrophosphatase/phosphodiesterase 3D structures\|Ectonucleotide pyrophosphatase/phosphodiesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Gorelik, A]]		[[Category: Gorelik, A]]
	[[Category: Illes, K]]		[[Category: Illes, K]]

OCA at 14:41, 6 November 2017

OCA — Mon, 06 Nov 2017 14:41:01 GMT

←Older revision		Revision as of 14:41, 6 November 2017
Line 3:		Line 3:
	<StructureSection load='5vem' size='340' side='right' caption='[[5vem]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5vem' size='340' side='right' caption='[[5vem]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5vem]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VEM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VEM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5vem]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VEM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VEM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5veo\|5veo]], [[5ven\|5ven]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5veo\|5veo]], [[5ven\|5ven]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ENPP5, UNQ550/PRO1107 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vem OCA], [http://pdbe.org/5vem PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vem RCSB], [http://www.ebi.ac.uk/pdbsum/5vem PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vem ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vem OCA], [http://pdbe.org/5vem PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vem RCSB], [http://www.ebi.ac.uk/pdbsum/5vem PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vem ProSAT]</span></td></tr>
	</table>		</table>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Gorelik, A]]		[[Category: Gorelik, A]]
	[[Category: Illes, K]]		[[Category: Illes, K]]

OCA at 04:39, 21 September 2017

OCA — Thu, 21 Sep 2017 04:39:47 GMT

←Older revision		Revision as of 04:39, 21 September 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5vem is ~~ON HOLD~~	+	==Human ectonucleotide pyrophosphatase / phosphodiesterase 5 (ENPP5, NPP5)==
		+	<StructureSection load='5vem' size='340' side='right' caption='[[5vem]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5vem]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VEM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VEM FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5veo\|5veo]], [[5ven\|5ven]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vem OCA], [http://pdbe.org/5vem PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vem RCSB], [http://www.ebi.ac.uk/pdbsum/5vem PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vem ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ENPP5_HUMAN ENPP5_HUMAN]] May play a role in neuronal cell communication. Lacks nucleotide pyrophosphatase and lysopholipase D activity (By similarity).[UniProtKB:P84039]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The ecto-nucleotide pyrophosphatase / phosphodiesterase (NPP) family of proteins mediates purinergic signaling by degrading extracellular nucleotides, and also participates in phospholipid metabolism. NPP5 (ENPP5) is the least characterized member of this group and its specific role is unknown. This enzyme does not display activity on certain nucleotides and on other typical NPP substrates. In order to gain insights into its function, we determined the crystal structure of human and murine NPP5. Structural comparison with close homologs revealed a key phenylalanine to tyrosine substitution that prevents efficient hydrolysis of nucleotide diphosphates and triphosphates; reversal of this mutation enabled degradation of these molecules. Interestingly, NPP5 is able to cleave nicotinamide adenine dinucleotide (NAD), suggesting a potential role of this enzyme in NAD-based neurotransmission. An NPP5-specific metal binding motif is found adjacent to the active site, although its significance is unclear. These findings expand our understanding of substrate specificity within the NPP family. This article is protected by copyright. All rights reserved.

-	~~Authors~~:	+	A Key Tyrosine Substitution Restricts Nucleotide Hydrolysis by the Ectoenzyme NPP5.,Gorelik A, Randriamihaja A, Illes K, Nagar B FEBS J. 2017 Sep 12. doi: 10.1111/febs.14266. PMID:28898552<ref>PMID:28898552</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5vem" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gorelik, A]]
		+	[[Category: Illes, K]]
		+	[[Category: Nagar, B]]
		+	[[Category: Randriamihaja, A]]
		+	[[Category: Hydrolase]]

OCA: Protected "5vem" [edit=sysop:move=sysop]

OCA — Wed, 12 Apr 2017 09:58:57 GMT

Protected "5vem" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:58, 12 April 2017

OCA: New page: '''Unreleased structure''' The entry 5vem is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 12 Apr 2017 09:58:55 GMT

New page: '''Unreleased structure''' The entry 5vem is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5vem is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]