5vgr - Revision history

OCA at 13:48, 4 October 2023

OCA — Wed, 04 Oct 2023 13:48:33 GMT

←Older revision		Revision as of 13:48, 4 October 2023
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	<StructureSection load='5vgr' size='340' side='right'caption='[[5vgr]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='5vgr' size='340' side='right'caption='[[5vgr]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5vgr]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VGR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5VGR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5vgr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VGR FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=GDP:GUANOSINE~~-~~5-DIPHOSPHATE'>GDP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.096Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~ATL3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=5~~&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5vgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vgr OCA], [~~http~~://pdbe.org/5vgr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5vgr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5vgr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5vgr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vgr OCA], [https://pdbe.org/5vgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vgr RCSB], [https://www.ebi.ac.uk/pdbsum/5vgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vgr ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/ATLA3_HUMAN ATLA3_HUMAN]] Hereditary sensory and autonomic neuropathy type 1. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/ATLA3_HUMAN ATLA3_HUMAN] Hereditary sensory and autonomic neuropathy type 1. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ATLA3_HUMAN ATLA3_HUMAN]] GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis.<ref>PMID:18270207</ref> <ref>PMID:19665976</ref>	+	[https://www.uniprot.org/uniprot/ATLA3_HUMAN ATLA3_HUMAN] GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis.<ref>PMID:18270207</ref> <ref>PMID:19665976</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Donnell~~, J P.O~~]]	+	[[Category: O'Donnell JP]]
-	[[Category: Sondermann, H]]	+	[[Category: Sondermann H]]
-	~~[[Category: G protein]]~~	+
-	~~[[Category: Gtpase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Membrane fusion~~]]	+

OCA at 09:33, 1 January 2020

OCA — Wed, 01 Jan 2020 09:33:34 GMT

←Older revision		Revision as of 09:33, 1 January 2020
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	==Human Atlastin-3, GDP-bound==		==Human Atlastin-3, GDP-bound==
-	<StructureSection load='5vgr' size='340' side='right' caption='[[5vgr]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='5vgr' size='340' side='right'caption='[[5vgr]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5vgr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VGR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5vgr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VGR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATL3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vgr OCA], [http://pdbe.org/5vgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vgr RCSB], [http://www.ebi.ac.uk/pdbsum/5vgr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vgr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vgr OCA], [http://pdbe.org/5vgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vgr RCSB], [http://www.ebi.ac.uk/pdbsum/5vgr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vgr ProSAT]</span></td></tr>
	</table>		</table>
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	</div>		</div>
	<div class="pdbe-citations 5vgr" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5vgr" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Atlastin 3D structures\|Atlastin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Donnell, J P.O]]		[[Category: Donnell, J P.O]]
	[[Category: Sondermann, H]]		[[Category: Sondermann, H]]

OCA at 10:45, 3 August 2017

OCA — Thu, 03 Aug 2017 10:45:07 GMT

←Older revision		Revision as of 10:45, 3 August 2017
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/ATLA3_HUMAN ATLA3_HUMAN]] GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis.<ref>PMID:18270207</ref> <ref>PMID:19665976</ref>		[[http://www.uniprot.org/uniprot/ATLA3_HUMAN ATLA3_HUMAN]] GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis.<ref>PMID:18270207</ref> <ref>PMID:19665976</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The endoplasmic reticulum (ER) forms a branched, dynamic membrane tubule network that is vital for cellular function. Branching arises from membrane fusion facilitated by the GTPase atlastin (ATL). Many metazoan genomes encode for three ATL isoforms that appear to fulfill partially redundant function despite differences in their intrinsic GTPase activity and localization within the ER; however, the underlying mechanistic differences between the isoforms are poorly understood. Here, we identify discrete temporal steps in the catalytic cycle for the two most dissimilar isoforms, ATL1 and ATL3, revealing an overall conserved progression of molecular events from nucleotide binding and hydrolysis to ATL dimerization and phosphate release. A crystal structure of ATL3 suggests a mechanism for the displacement of the catalytic Mg2+ ion following guanosine triphosphate (GTP) hydrolysis. Together, the data extend the mechanistic framework for how GTP hydrolysis drives conformational changes in ATL and how the cycle is reset for subsequent rounds of catalysis.
		+
		+	Timing and Reset Mechanism of GTP Hydrolysis-Driven Conformational Changes of Atlastin.,O'Donnell JP, Cooley RB, Kelly CM, Miller K, Andersen OS, Rusinova R, Sondermann H Structure. 2017 Jul 5;25(7):997-1010.e4. doi: 10.1016/j.str.2017.05.007. Epub, 2017 Jun 9. PMID:28602821<ref>PMID:28602821</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5vgr" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:51, 17 May 2017

OCA — Wed, 17 May 2017 15:51:11 GMT

←Older revision		Revision as of 15:51, 17 May 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5vgr is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Human Atlastin-3, GDP-bound==
-		+	<StructureSection load='5vgr' size='340' side='right' caption='[[5vgr]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5vgr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VGR FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vgr OCA], [http://pdbe.org/5vgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vgr RCSB], [http://www.ebi.ac.uk/pdbsum/5vgr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vgr ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/ATLA3_HUMAN ATLA3_HUMAN]] Hereditary sensory and autonomic neuropathy type 1. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ATLA3_HUMAN ATLA3_HUMAN]] GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis.<ref>PMID:18270207</ref> <ref>PMID:19665976</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Donnell, J P.O]]
		+	[[Category: Sondermann, H]]
		+	[[Category: G protein]]
		+	[[Category: Gtpase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Membrane fusion]]

OCA at 11:18, 4 May 2017

OCA — Thu, 04 May 2017 11:18:30 GMT

←Older revision		Revision as of 11:18, 4 May 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5vgr is ON HOLD	+	The entry 5vgr is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5vgr" [edit=sysop:move=sysop]

OCA — Wed, 19 Apr 2017 11:25:49 GMT

Protected "5vgr" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:25, 19 April 2017

OCA: New page: '''Unreleased structure''' The entry 5vgr is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 19 Apr 2017 11:25:48 GMT

New page: '''Unreleased structure''' The entry 5vgr is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5vgr is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]