5vja - Revision history

OCA at 13:49, 4 October 2023

OCA — Wed, 04 Oct 2023 13:49:50 GMT

←Older revision		Revision as of 13:49, 4 October 2023
Line 1:		Line 1:

	==Crystal Structure of human zipper-interacting protein kinase (ZIPK, alias DAPK3) in complex with a pyrazolo[3,4-d]pyrimidinone ligand (HS38)==		==Crystal Structure of human zipper-interacting protein kinase (ZIPK, alias DAPK3) in complex with a pyrazolo[3,4-d]pyrimidinone ligand (HS38)==
-	<StructureSection load='5vja' size='340' side='right' caption='[[5vja]], [[Resolution\|resolution]] 2.46Å' scene=''>	+	<StructureSection load='5vja' size='340' side='right'caption='[[5vja]], [[Resolution\|resolution]] 2.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5vja]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VJA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5VJA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5vja]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VJA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DUK:(2R)-2-{[1-(3-chlorophenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl}propanamide'>DUK</scene>, <scene name='pdbligand=ILE:ISOLEUCINE'>ILE</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.46Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DAPK3, ZIPK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DUK:(2R)-2-{[1-(3-chlorophenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl}propanamide'>DUK</scene>, <scene name='pdbligand=ILE:ISOLEUCINE'>ILE</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vja OCA], [https://pdbe.org/5vja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vja RCSB], [https://www.ebi.ac.uk/pdbsum/5vja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vja ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5vja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vja OCA], [~~http~~://pdbe.org/5vja PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5vja RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5vja PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5vja ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DAPK3_HUMAN DAPK3_HUMAN]] Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation, actin cytoskeleton reorganization, cell motility, smooth muscle contraction, and mitosis, particularly cytokinesis. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A, and the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Phosphorylates STAT3 and enhances its transcriptional activity. Positively regulates the canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Can disrupt the NLK-TCF7L2 complex thereby influencing the phosphorylation of TCF7L2 by NLK. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. Involved in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, its association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition.<ref>PMID:10356987</ref> <ref>PMID:17126281</ref> <ref>PMID:12917339</ref> <ref>PMID:12560483</ref> <ref>PMID:15367680</ref> <ref>PMID:18995835</ref> <ref>PMID:16219639</ref> <ref>PMID:17158456</ref> <ref>PMID:18515077</ref> <ref>PMID:18084323</ref> <ref>PMID:21454679</ref> <ref>PMID:21408167</ref> Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B.<ref>PMID:10356987</ref> <ref>PMID:17126281</ref> <ref>PMID:12917339</ref> <ref>PMID:12560483</ref> <ref>PMID:15367680</ref> <ref>PMID:18995835</ref> <ref>PMID:16219639</ref> <ref>PMID:17158456</ref> <ref>PMID:18515077</ref> <ref>PMID:18084323</ref> <ref>PMID:21454679</ref> <ref>PMID:21408167</ref>	+	[https://www.uniprot.org/uniprot/DAPK3_HUMAN DAPK3_HUMAN] Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation, actin cytoskeleton reorganization, cell motility, smooth muscle contraction, and mitosis, particularly cytokinesis. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A, and the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Phosphorylates STAT3 and enhances its transcriptional activity. Positively regulates the canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Can disrupt the NLK-TCF7L2 complex thereby influencing the phosphorylation of TCF7L2 by NLK. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. Involved in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, its association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition.<ref>PMID:10356987</ref> <ref>PMID:17126281</ref> <ref>PMID:12917339</ref> <ref>PMID:12560483</ref> <ref>PMID:15367680</ref> <ref>PMID:18995835</ref> <ref>PMID:16219639</ref> <ref>PMID:17158456</ref> <ref>PMID:18515077</ref> <ref>PMID:18084323</ref> <ref>PMID:21454679</ref> <ref>PMID:21408167</ref> Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B.<ref>PMID:10356987</ref> <ref>PMID:17126281</ref> <ref>PMID:12917339</ref> <ref>PMID:12560483</ref> <ref>PMID:15367680</ref> <ref>PMID:18995835</ref> <ref>PMID:16219639</ref> <ref>PMID:17158456</ref> <ref>PMID:18515077</ref> <ref>PMID:18084323</ref> <ref>PMID:21454679</ref> <ref>PMID:21408167</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5vja" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5vja" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Death-associated protein kinase 3D structures\|Death-associated protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Non-specific serine/threonine protein kinase~~]]	+	[[Category: Large Structures]]
-	[[Category: Alexander, L]]	+	[[Category: Alexander L]]
-	[[Category: Carlson~~, D A~~]]	+	[[Category: Carlson DA]]
-	[[Category: Haystead~~, T A.J~~]]	+	[[Category: Haystead TAJ]]
-	[[Category: Hughes~~, P F~~]]	+	[[Category: Hughes PF]]
-	[[Category: Knapp, S]]	+	[[Category: Knapp S]]
-	[[Category: MacDonald~~, J A~~]]	+	[[Category: MacDonald JA]]
-	[[Category: Redondo, C]]	+	[[Category: Redondo C]]
-	[[Category: Singer~~, M R~~]]	+	[[Category: Singer MR]]
-	[[Category: Sutherland, C]]	+	[[Category: Sutherland C]]
-	~~[[Category: Death-associated protein kinase 3]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Smooth muscle contraction]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 07:07, 31 October 2018

OCA — Wed, 31 Oct 2018 07:07:14 GMT

←Older revision		Revision as of 07:07, 31 October 2018
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	<StructureSection load='5vja' size='340' side='right' caption='[[5vja]], [[Resolution\|resolution]] 2.46Å' scene=''>		<StructureSection load='5vja' size='340' side='right' caption='[[5vja]], [[Resolution\|resolution]] 2.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5vja]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VJA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VJA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5vja]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VJA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VJA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DUK:(2R)-2-{[1-(3-chlorophenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl}propanamide'>DUK</scene>, <scene name='pdbligand=ILE:ISOLEUCINE'>ILE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DUK:(2R)-2-{[1-(3-chlorophenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl}propanamide'>DUK</scene>, <scene name='pdbligand=ILE:ISOLEUCINE'>ILE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DAPK3, ZIPK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vja OCA], [http://pdbe.org/5vja PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vja RCSB], [http://www.ebi.ac.uk/pdbsum/5vja PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vja ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vja OCA], [http://pdbe.org/5vja PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vja RCSB], [http://www.ebi.ac.uk/pdbsum/5vja PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vja ProSAT]</span></td></tr>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Alexander, L]]		[[Category: Alexander, L]]

OCA at 21:39, 9 August 2018

OCA — Thu, 09 Aug 2018 21:39:58 GMT

←Older revision		Revision as of 21:39, 9 August 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5vja is ~~ON HOLD~~ ~~until Oct 19 2019~~	+	==Crystal Structure of human zipper-interacting protein kinase (ZIPK, alias DAPK3) in complex with a pyrazolo[3,4-d]pyrimidinone ligand (HS38)==
		+	<StructureSection load='5vja' size='340' side='right' caption='[[5vja]], [[Resolution\|resolution]] 2.46Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5vja]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VJA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VJA FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DUK:(2R)-2-{[1-(3-chlorophenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl}propanamide'>DUK</scene>, <scene name='pdbligand=ILE:ISOLEUCINE'>ILE</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vja OCA], [http://pdbe.org/5vja PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vja RCSB], [http://www.ebi.ac.uk/pdbsum/5vja PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vja ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DAPK3_HUMAN DAPK3_HUMAN]] Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation, actin cytoskeleton reorganization, cell motility, smooth muscle contraction, and mitosis, particularly cytokinesis. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A, and the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Phosphorylates STAT3 and enhances its transcriptional activity. Positively regulates the canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Can disrupt the NLK-TCF7L2 complex thereby influencing the phosphorylation of TCF7L2 by NLK. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. Involved in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, its association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition.<ref>PMID:10356987</ref> <ref>PMID:17126281</ref> <ref>PMID:12917339</ref> <ref>PMID:12560483</ref> <ref>PMID:15367680</ref> <ref>PMID:18995835</ref> <ref>PMID:16219639</ref> <ref>PMID:17158456</ref> <ref>PMID:18515077</ref> <ref>PMID:18084323</ref> <ref>PMID:21454679</ref> <ref>PMID:21408167</ref> Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B.<ref>PMID:10356987</ref> <ref>PMID:17126281</ref> <ref>PMID:12917339</ref> <ref>PMID:12560483</ref> <ref>PMID:15367680</ref> <ref>PMID:18995835</ref> <ref>PMID:16219639</ref> <ref>PMID:17158456</ref> <ref>PMID:18515077</ref> <ref>PMID:18084323</ref> <ref>PMID:21454679</ref> <ref>PMID:21408167</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Sustained vascular smooth muscle hypercontractility promotes hypertension and cardiovascular disease. The etiology of hypercontractility is not completely understood. New therapeutic targets remain vitally important for drug discovery. Here we report that Pim kinases, in combination with DAPK3, regulate contractility and control hypertension. Using a co-crystal structure of lead molecule (HS38) in complex with DAPK3, a dual Pim/DAPK3 inhibitor (HS56) and selective DAPK3 inhibitors (HS94 and HS148) were developed to provide mechanistic insight into the polypharmacology of hypertension. In vitro and ex vivo studies indicated that Pim kinases directly phosphorylate smooth muscle targets and that Pim/DAPK3 inhibition, unlike selective DAPK3 inhibition, significantly reduces contractility. In vivo, HS56 decreased blood pressure in spontaneously hypertensive mice in a dose-dependent manner without affecting heart rate. These findings suggest including Pim kinase inhibition within a multi-target engagement strategy for hypertension management. HS56 represents a significant step in the development of molecularly targeted antihypertensive medications.

-	~~Authors:~~ Carlson~~, D.A.~~, Singer~~, M.R.~~, Sutherland, C., Redondo, C., Alexander~~, L.~~, Hughes~~, P.F.~~, Knapp, S., MacDonald, J.A., ~~Haystead, T~~.A.J.	+	Targeting Pim Kinases and DAPK3 to Control Hypertension.,Carlson DA, Singer MR, Sutherland C, Redondo C, Alexander LT, Hughes PF, Knapp S, Gurley SB, Sparks MA, MacDonald JA, Haystead TAJ Cell Chem Biol. 2018 Jul 4. pii: S2451-9456(18)30220-4. doi:, 10.1016/j.chembiol.2018.06.006. PMID:30033129<ref>PMID:30033129</ref>

-	~~Description: Crystal Structure of human zipper-interacting protein kinase (ZIPK~~, ~~alias DAPK3) in complex with~~ a ~~pyrazolo~~[~~3,4~~-d]~~pyrimidinone ligand (HS38)~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Singer~~, ~~M.R~~]]	+	<div class="pdbe-citations 5vja" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Sutherland~~, C]]	+	== References ==
-	[[Category: ~~Macdonald~~, ~~J.A~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Non-specific serine/threonine protein kinase]]
		+	[[Category: Alexander, L]]
		+	[[Category: Carlson, D A]]
		+	[[Category: Haystead, T A.J]]
		+	[[Category: Hughes, P F]]
	[[Category: Knapp, S]]		[[Category: Knapp, S]]
-	[[Category: ~~Carlson~~, D.A]]	+	[[Category: MacDonald, J A]]
	[[Category: Redondo, C]]		[[Category: Redondo, C]]
-	[[Category: ~~Hughes~~, ~~P.F~~]]	+	[[Category: Singer, M R]]
-	[[Category: ~~Alexander~~, L]]	+	[[Category: Sutherland, C]]
-	[[Category: ~~Haystead, T.A.J~~]]	+	[[Category: Death-associated protein kinase 3]]
		+	[[Category: Inhibitor]]
		+	[[Category: Smooth muscle contraction]]
		+	[[Category: Transferase]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 03:46, 25 April 2018

OCA — Wed, 25 Apr 2018 03:46:16 GMT

←Older revision		Revision as of 03:46, 25 April 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5vja is ON HOLD until ~~Apr~~ 19 2019	+	The entry 5vja is ON HOLD until Oct 19 2019

	Authors: Carlson, D.A., Singer, M.R., Sutherland, C., Redondo, C., Alexander, L., Hughes, P.F., Knapp, S., MacDonald, J.A., Haystead, T.A.J.		Authors: Carlson, D.A., Singer, M.R., Sutherland, C., Redondo, C., Alexander, L., Hughes, P.F., Knapp, S., MacDonald, J.A., Haystead, T.A.J.
Line 7:		Line 7:
	Description: Crystal Structure of human zipper-interacting protein kinase (ZIPK, alias DAPK3) in complex with a pyrazolo[3,4-d]pyrimidinone ligand (HS38)		Description: Crystal Structure of human zipper-interacting protein kinase (ZIPK, alias DAPK3) in complex with a pyrazolo[3,4-d]pyrimidinone ligand (HS38)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Macdonald, J.A]]
	[[Category: Singer, M.R]]		[[Category: Singer, M.R]]
	[[Category: Sutherland, C]]		[[Category: Sutherland, C]]
		+	[[Category: Macdonald, J.A]]
	[[Category: Knapp, S]]		[[Category: Knapp, S]]
-	[[Category: Haystead, T.A.J]]
	[[Category: Carlson, D.A]]		[[Category: Carlson, D.A]]
-	[[Category: Alexander, L]]
-	[[Category: Hughes, P.F]]
	[[Category: Redondo, C]]		[[Category: Redondo, C]]
		+	[[Category: Hughes, P.F]]
		+	[[Category: Alexander, L]]
		+	[[Category: Haystead, T.A.J]]

OCA at 14:04, 27 September 2017

OCA — Wed, 27 Sep 2017 14:04:26 GMT

←Older revision		Revision as of 14:04, 27 September 2017
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Macdonald, J.A]]		[[Category: Macdonald, J.A]]
-	[[Category: Carlson, D.A]]
-	[[Category: Alexander, L]]
	[[Category: Singer, M.R]]		[[Category: Singer, M.R]]
	[[Category: Sutherland, C]]		[[Category: Sutherland, C]]
	[[Category: Knapp, S]]		[[Category: Knapp, S]]
		+	[[Category: Haystead, T.A.J]]
		+	[[Category: Carlson, D.A]]
		+	[[Category: Alexander, L]]
	[[Category: Hughes, P.F]]		[[Category: Hughes, P.F]]
	[[Category: Redondo, C]]		[[Category: Redondo, C]]
-	[[Category: Haystead, T.A.J]]

OCA at 13:54, 17 May 2017

OCA — Wed, 17 May 2017 13:54:03 GMT

←Older revision		Revision as of 13:54, 17 May 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5vja is ON HOLD	+	The entry 5vja is ON HOLD until Apr 19 2019

	Authors: Carlson, D.A., Singer, M.R., Sutherland, C., Redondo, C., Alexander, L., Hughes, P.F., Knapp, S., MacDonald, J.A., Haystead, T.A.J.		Authors: Carlson, D.A., Singer, M.R., Sutherland, C., Redondo, C., Alexander, L., Hughes, P.F., Knapp, S., MacDonald, J.A., Haystead, T.A.J.

OCA at 11:22, 4 May 2017

OCA — Thu, 04 May 2017 11:22:10 GMT

←Older revision		Revision as of 11:22, 4 May 2017
Line 3:		Line 3:
	The entry 5vja is ON HOLD		The entry 5vja is ON HOLD

-	Authors: Carlson, D.A., Singer, M.R., Sutherland, C., Redondo, C., Alexander, L., Hughes, P.F., Knapp, S, MacDonald, J.A., Haystead, T.A.J	+	Authors: Carlson, D.A., Singer, M.R., Sutherland, C., Redondo, C., Alexander, L., Hughes, P.F., Knapp, S., MacDonald, J.A., Haystead, T.A.J.

	Description: Crystal Structure of human zipper-interacting protein kinase (ZIPK, alias DAPK3) in complex with a pyrazolo[3,4-d]pyrimidinone ligand (HS38)		Description: Crystal Structure of human zipper-interacting protein kinase (ZIPK, alias DAPK3) in complex with a pyrazolo[3,4-d]pyrimidinone ligand (HS38)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Macdonald, J.A]]
	[[Category: Carlson, D.A]]		[[Category: Carlson, D.A]]
	[[Category: Alexander, L]]		[[Category: Alexander, L]]
	[[Category: Singer, M.R]]		[[Category: Singer, M.R]]
	[[Category: Sutherland, C]]		[[Category: Sutherland, C]]
		+	[[Category: Knapp, S]]
	[[Category: Hughes, P.F]]		[[Category: Hughes, P.F]]
	[[Category: Redondo, C]]		[[Category: Redondo, C]]
-	[[Category: Knapp, S, Macdonald, J.A]]
	[[Category: Haystead, T.A.J]]		[[Category: Haystead, T.A.J]]

OCA: Protected "5vja" [edit=sysop:move=sysop]

OCA — Thu, 27 Apr 2017 12:21:03 GMT

Protected "5vja" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:21, 27 April 2017

OCA: New page: '''Unreleased structure''' The entry 5vja is ON HOLD Authors: Carlson, D.A., Singer, M.R., Sutherland, C., Redondo, C., Alexander, L., Hughes, P.F., Knapp, S, MacDonald, J.A., Haystead,...

OCA — Thu, 27 Apr 2017 12:21:02 GMT

New page: '''Unreleased structure''' The entry 5vja is ON HOLD Authors: Carlson, D.A., Singer, M.R., Sutherland, C., Redondo, C., Alexander, L., Hughes, P.F., Knapp, S, MacDonald, J.A., Haystead,...

New page

'''Unreleased structure'''

The entry 5vja is ON HOLD

Authors: Carlson, D.A., Singer, M.R., Sutherland, C., Redondo, C., Alexander, L., Hughes, P.F., Knapp, S, MacDonald, J.A., Haystead, T.A.J

Description: Crystal Structure of human zipper-interacting protein kinase (ZIPK, alias DAPK3) in complex with a pyrazolo[3,4-d]pyrimidinone ligand (HS38)
[[Category: Unreleased Structures]]
[[Category: Carlson, D.A]]
[[Category: Alexander, L]]
[[Category: Singer, M.R]]
[[Category: Sutherland, C]]
[[Category: Hughes, P.F]]
[[Category: Redondo, C]]
[[Category: Knapp, S, Macdonald, J.A]]
[[Category: Haystead, T.A.J]]