5vni - Revision history

OCA at 13:52, 4 October 2023

OCA — Wed, 04 Oct 2023 13:52:18 GMT

←Older revision		Revision as of 13:52, 4 October 2023
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	==Crystal structure of Sec23a/Sec24a/Sec22 complexed with a C-terminal FA sorting motif==		==Crystal structure of Sec23a/Sec24a/Sec22 complexed with a C-terminal FA sorting motif==
-	<StructureSection load='5vni' size='340' side='right' caption='[[5vni]], [[Resolution\|resolution]] 2.79Å' scene=''>	+	<StructureSection load='5vni' size='340' side='right'caption='[[5vni]], [[Resolution\|resolution]] 2.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5vni]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~] and [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VNI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5VNI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5vni]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VNI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VNI FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.788Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vne\|5vne]]~~, [[~~5vnf~~\|~~5vnf]], [[5vng\|5vng]], [[5vnh\|5vnh]], [[5vnj\|5vnj]], [[5vnk\|5vnk]], [[5vnl\|5vnl]], [[5vnm\|5vnm]], [[5vnn\|5vnn]], [[5vno\|5vno~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>SEC23A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN]), SEC24A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN]), Sec22b, Sec22l1 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vni OCA], [https://pdbe.org/5vni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vni RCSB], [https://www.ebi.ac.uk/pdbsum/5vni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vni ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5vni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vni OCA], [~~http~~://pdbe.org/5vni PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5vni RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5vni PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5vni ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/SC23A_HUMAN SC23A_HUMAN]] Defects in SEC23A are the cause of craniolenticulosutural dysplasia (CLSD) [MIM:[~~http~~://omim.org/entry/607812 607812]]; also known as cranio-lenticulo-sutural dysplasia. CLSD is an autosomal recessive syndrome characterized by late-closing fontanels, sutural cataracts, facial dysmorphisms and skeletal defects.<ref>PMID:16980979</ref>	+	[https://www.uniprot.org/uniprot/SC23A_HUMAN SC23A_HUMAN] Defects in SEC23A are the cause of craniolenticulosutural dysplasia (CLSD) [MIM:[https://omim.org/entry/607812 607812]; also known as cranio-lenticulo-sutural dysplasia. CLSD is an autosomal recessive syndrome characterized by late-closing fontanels, sutural cataracts, facial dysmorphisms and skeletal defects.<ref>PMID:16980979</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SC23A_HUMAN SC23A_HUMAN]] Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex. [[http://www.uniprot.org/uniprot/SC22B_MOUSE SC22B_MOUSE]] SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. [[http://www.uniprot.org/uniprot/SC24A_HUMAN SC24A_HUMAN]] Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.	+	[https://www.uniprot.org/uniprot/SC23A_HUMAN SC23A_HUMAN] Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Goldberg, J~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Ma, W~~]]	+	[[Category: Goldberg J]]
-	[[Category: ~~Copii]]~~	+	[[Category: Ma W]]
-	~~[[Category: Er retention]]~~	+
-	~~[[Category: P24]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Trafficking~~]]	+

OCA at 06:44, 16 November 2017

OCA — Thu, 16 Nov 2017 06:44:04 GMT

←Older revision		Revision as of 06:44, 16 November 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5vni is ~~ON HOLD~~	+	==Crystal structure of Sec23a/Sec24a/Sec22 complexed with a C-terminal FA sorting motif==
		+	<StructureSection load='5vni' size='340' side='right' caption='[[5vni]], [[Resolution\|resolution]] 2.79Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5vni]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VNI FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vne\|5vne]], [[5vnf\|5vnf]], [[5vng\|5vng]], [[5vnh\|5vnh]], [[5vnj\|5vnj]], [[5vnk\|5vnk]], [[5vnl\|5vnl]], [[5vnm\|5vnm]], [[5vnn\|5vnn]], [[5vno\|5vno]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SEC23A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), SEC24A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Sec22b, Sec22l1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vni OCA], [http://pdbe.org/5vni PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vni RCSB], [http://www.ebi.ac.uk/pdbsum/5vni PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vni ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/SC23A_HUMAN SC23A_HUMAN]] Defects in SEC23A are the cause of craniolenticulosutural dysplasia (CLSD) [MIM:[http://omim.org/entry/607812 607812]]; also known as cranio-lenticulo-sutural dysplasia. CLSD is an autosomal recessive syndrome characterized by late-closing fontanels, sutural cataracts, facial dysmorphisms and skeletal defects.<ref>PMID:16980979</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SC23A_HUMAN SC23A_HUMAN]] Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex. [[http://www.uniprot.org/uniprot/SC22B_MOUSE SC22B_MOUSE]] SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. [[http://www.uniprot.org/uniprot/SC24A_HUMAN SC24A_HUMAN]] Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Native cargo proteins exit the endoplasmic reticulum (ER) in COPII-coated vesicles, whereas resident and misfolded proteins are substantially excluded from vesicles by a retention mechanism that remains unresolved. We probed the ER retention process using the proteostasis regulator 4-phenylbutyrate (4-PBA), which we show targets COPII protein to reduce the stringency of retention. 4-PBA competes with p24 proteins to bind COPII. When p24 protein uptake is blocked, COPII vesicles package resident proteins and an ER-trapped mutant LDL receptor. We further show that 4-PBA triggers the secretion of a KDEL-tagged luminal resident, implying that a compromised retention mechanism causes saturation of the KDEL retrieval system. The results indicate that stringent ER retention requires the COPII coat machinery to actively sort biosynthetic cargo from diffusible misfolded and resident ER proteins.

-	~~Authors: Ma~~, W., Goldberg, J.	+	ER retention is imposed by COPII protein sorting and attenuated by 4-phenylbutyrate.,Ma W, Goldberg E, Goldberg J Elife. 2017 Jun 8;6. pii: e26624. doi: 10.7554/eLife.26624. PMID:28594326<ref>PMID:28594326</ref>

-	~~Description: Crystal structure of Sec23a~~/~~Sec24a/Sec22 complexed with~~ a C-~~terminal FA sorting motif~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Ma, W~~]]	+	<div class="pdbe-citations 5vni" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Goldberg, J]]		[[Category: Goldberg, J]]
		+	[[Category: Ma, W]]
		+	[[Category: Copii]]
		+	[[Category: Er retention]]
		+	[[Category: P24]]
		+	[[Category: Protein transport]]
		+	[[Category: Trafficking]]

OCA: Protected "5vni" [edit=sysop:move=sysop]

OCA — Wed, 10 May 2017 11:13:25 GMT

Protected "5vni" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:13, 10 May 2017

OCA: New page: '''Unreleased structure''' The entry 5vni is ON HOLD Authors: Ma, W., Goldberg, J. Description: Crystal structure of Sec23a/Sec24a/Sec22 complexed with a C-terminal FA sorting motif [[...

OCA — Wed, 10 May 2017 11:13:23 GMT

New page: '''Unreleased structure''' The entry 5vni is ON HOLD Authors: Ma, W., Goldberg, J. Description: Crystal structure of Sec23a/Sec24a/Sec22 complexed with a C-terminal FA sorting motif [[...

New page

'''Unreleased structure'''

The entry 5vni is ON HOLD

Authors: Ma, W., Goldberg, J.

Description: Crystal structure of Sec23a/Sec24a/Sec22 complexed with a C-terminal FA sorting motif
[[Category: Unreleased Structures]]
[[Category: Ma, W]]
[[Category: Goldberg, J]]