5von - Revision history

OCA at 13:53, 4 October 2023

OCA — Wed, 04 Oct 2023 13:53:32 GMT

←Older revision		Revision as of 13:53, 4 October 2023
Line 1:		Line 1:

	==Methionine synthase folate-binding domain from Thermus thermophilus HB8==		==Methionine synthase folate-binding domain from Thermus thermophilus HB8==
-	<StructureSection load='5von' size='340' side='right' caption='[[5von]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='5von' size='340' side='right'caption='[[5von]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5von]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Thet8 Thet8~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VON OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5VON FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5von]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VON FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5voo\|5voo]]~~, [[~~5vop~~\|~~5vop~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~TTHA0618 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5von FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5von OCA], [https://pdbe.org/5von PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5von RCSB], [https://www.ebi.ac.uk/pdbsum/5von PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5von ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5von FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5von OCA], [~~http~~://pdbe.org/5von PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5von RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5von PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5von ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q5SKM5_THET8 Q5SKM5_THET8]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5von" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5von" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Methionine synthase 3D structures\|Methionine synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Thet8~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Koutmos, M~~]]	+	[[Category: Thermus thermophilus HB8]]
-	[[Category: ~~Yamada, K~~]]	+	[[Category: Koutmos M]]
-	[[Category: ~~B12 binding]]~~	+	[[Category: Yamada K]]
-	~~[[Category: Methyltransferase]]~~	+
-	~~[[Category: Pterin binding]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 05:53, 16 May 2018

OCA — Wed, 16 May 2018 05:53:40 GMT

←Older revision		Revision as of 05:53, 16 May 2018
Line 3:		Line 3:
	<StructureSection load='5von' size='340' side='right' caption='[[5von]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='5von' size='340' side='right' caption='[[5von]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5von]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VON OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VON FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5von]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VON OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VON FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5voo\|5voo]], [[5vop\|5vop]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5voo\|5voo]], [[5vop\|5vop]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TTHA0618 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5von FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5von OCA], [http://pdbe.org/5von PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5von RCSB], [http://www.ebi.ac.uk/pdbsum/5von PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5von ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5von FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5von OCA], [http://pdbe.org/5von PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5von RCSB], [http://www.ebi.ac.uk/pdbsum/5von PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5von ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Methyl transfer between methyltetrahydrofolate and corrinoid molecules is a key reaction in biology that is catalyzed by a number of enzymes in many prokaryotic and eukaryotic organisms. One classic example of such an enzyme is cobalamin-dependent methionine synthase (MS). MS is a large modular protein that utilizes an SN2-type mechanism to catalyze the chemically challenging methyl transfer from the tertiary amine (N5) of methyltetrahydrofolate to homocysteine in order to form methionine. Despite over half a century of study, many questions remain about how folate-dependent methyltransferases, and MS in particular, function. Here, the structure of the folate-binding (Fol) domain of MS from Thermus thermophilus is reported in the presence and absence of methyltetrahydrofolate. It is found that the methyltetrahydrofolate-binding environment is similar to those of previously described methyltransferases, highlighting the conserved role of this domain in binding, and perhaps activating, the methyltetrahydrofolate substrate. These structural studies further reveal a new distinct and uncharacterized topology in the C-terminal region of MS Fol domains. Furthermore, it is found that in contrast to the canonical TIM-barrel beta8alpha8 fold found in all other folate-binding domains, MS Fol domains exhibit a unique beta8alpha7 fold. It is posited that these structural differences are important for MS function.
		+
		+	The folate-binding module of Thermus thermophilus cobalamin-dependent methionine synthase displays a distinct variation of the classical TIM barrel: a TIM barrel with a `twist'.,Yamada K, Koutmos M Acta Crystallogr D Struct Biol. 2018 Jan 1;74(Pt 1):41-51. doi:, 10.1107/S2059798317018290. Epub 2018 Jan 1. PMID:29372898<ref>PMID:29372898</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5von" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Thet8]]
	[[Category: Koutmos, M]]		[[Category: Koutmos, M]]
	[[Category: Yamada, K]]		[[Category: Yamada, K]]

OCA at 06:53, 17 January 2018

OCA — Wed, 17 Jan 2018 06:53:28 GMT

←Older revision		Revision as of 06:53, 17 January 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5von is ~~ON HOLD until Paper Publication~~	+	==Methionine synthase folate-binding domain from Thermus thermophilus HB8==
-		+	<StructureSection load='5von' size='340' side='right' caption='[[5von]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5von]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VON OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VON FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5voo\|5voo]], [[5vop\|5vop]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5von FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5von OCA], [http://pdbe.org/5von PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5von RCSB], [http://www.ebi.ac.uk/pdbsum/5von PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5von ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Koutmos, M]]
		+	[[Category: Yamada, K]]
		+	[[Category: B12 binding]]
		+	[[Category: Methyltransferase]]
		+	[[Category: Pterin binding]]
		+	[[Category: Transferase]]

OCA at 14:08, 27 September 2017

OCA — Wed, 27 Sep 2017 14:08:41 GMT

←Older revision		Revision as of 14:08, 27 September 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5von is ON HOLD	+	The entry 5von is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5von" [edit=sysop:move=sysop]

OCA — Wed, 10 May 2017 11:16:17 GMT

Protected "5von" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:16, 10 May 2017

OCA: New page: '''Unreleased structure''' The entry 5von is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 10 May 2017 11:16:15 GMT

New page: '''Unreleased structure''' The entry 5von is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5von is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]