5vql - Revision history

OCA at 14:11, 13 March 2024

OCA — Wed, 13 Mar 2024 14:11:55 GMT

←Older revision		Revision as of 14:11, 13 March 2024
Line 3:		Line 3:
	<StructureSection load='5vql' size='340' side='right'caption='[[5vql]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='5vql' size='340' side='right'caption='[[5vql]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5vql]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VQL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5VQL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5vql]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VQL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9GS:5-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-N-{[4-(ethylsulfonyl)phenyl]methyl}spiro[cyclopentane-1,3-pyrrolo[3,2-b]pyridine]-1(2H)-carboxamide'>9GS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vb3\|5vb3]], [[5vb5\|5vb5]], [[5vb6\|5vb6]], [[5vb7\|5vb7]], [[5vqk\|5vqk]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9GS:5-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-N-{[4-(ethylsulfonyl)phenyl]methyl}spiro[cyclopentane-1,3-pyrrolo[3,2-b]pyridine]-1(2H)-carboxamide'>9GS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5vql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vql OCA], [~~http~~://pdbe.org/5vql PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5vql RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5vql PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5vql ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vql OCA], [https://pdbe.org/5vql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vql RCSB], [https://www.ebi.ac.uk/pdbsum/5vql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vql ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.	+	[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref> [https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Li, X]]	+	[[Category: Li X]]
-	~~[[Category: Nuclear hormone receptor]]~~	+
-	~~[[Category: Nuclear receptor]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 08:43, 30 September 2020

OCA — Wed, 30 Sep 2020 08:43:27 GMT

←Older revision		Revision as of 08:43, 30 September 2020
Line 1:		Line 1:

	==X-ray co-structure of nuclear receptor ROR-gammat Ligand Binding Domain with a inverse agonist and SRC2 peptide==		==X-ray co-structure of nuclear receptor ROR-gammat Ligand Binding Domain with a inverse agonist and SRC2 peptide==
-	<StructureSection load='5vql' size='340' side='right' caption='[[5vql]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='5vql' size='340' side='right'caption='[[5vql]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5vql]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VQL OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5VQL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5vql]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VQL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5VQL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9GS:5-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-N-{[4-(ethylsulfonyl)phenyl]methyl}spiro[cyclopentane-1,3-pyrrolo[3,2-b]pyridine]-1(2H)-carboxamide'>9GS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9GS:5-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-N-{[4-(ethylsulfonyl)phenyl]methyl}spiro[cyclopentane-1,3-pyrrolo[3,2-b]pyridine]-1(2H)-carboxamide'>9GS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vb3\|5vb3]], [[5vb5\|5vb5]], [[5vb6\|5vb6]], [[5vb7\|5vb7]], [[5vqk\|5vqk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vb3\|5vb3]], [[5vb5\|5vb5]], [[5vb6\|5vb6]], [[5vb7\|5vb7]], [[5vqk\|5vqk]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5vql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vql OCA], [http://pdbe.org/5vql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vql RCSB], [http://www.ebi.ac.uk/pdbsum/5vql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vql ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5vql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vql OCA], [http://pdbe.org/5vql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vql RCSB], [http://www.ebi.ac.uk/pdbsum/5vql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vql ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 12:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Li, X]]		[[Category: Li, X]]
	[[Category: Nuclear hormone receptor]]		[[Category: Nuclear hormone receptor]]
	[[Category: Nuclear receptor]]		[[Category: Nuclear receptor]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 05:24, 16 May 2018

OCA — Wed, 16 May 2018 05:24:23 GMT

←Older revision		Revision as of 05:24, 16 May 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5vql is ~~ON HOLD until Paper Publication~~	+	==X-ray co-structure of nuclear receptor ROR-gammat Ligand Binding Domain with a inverse agonist and SRC2 peptide==
-		+	<StructureSection load='5vql' size='340' side='right' caption='[[5vql]], [[Resolution\|resolution]] 2.70Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5vql]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VQL FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9GS:5-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-N-{[4-(ethylsulfonyl)phenyl]methyl}spiro[cyclopentane-1,3-pyrrolo[3,2-b]pyridine]-1(2H)-carboxamide'>9GS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vb3\|5vb3]], [[5vb5\|5vb5]], [[5vb6\|5vb6]], [[5vb7\|5vb7]], [[5vqk\|5vqk]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vql OCA], [http://pdbe.org/5vql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vql RCSB], [http://www.ebi.ac.uk/pdbsum/5vql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vql ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Li, X]]
		+	[[Category: Nuclear hormone receptor]]
		+	[[Category: Nuclear receptor]]
		+	[[Category: Transcription]]

OCA: Protected "5vql" [edit=sysop:move=sysop]

OCA — Wed, 17 May 2017 14:07:27 GMT

Protected "5vql" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:07, 17 May 2017

OCA: New page: '''Unreleased structure''' The entry 5vql is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 17 May 2017 14:07:26 GMT

New page: '''Unreleased structure''' The entry 5vql is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5vql is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]