5vtm - Revision history

OCA at 13:58, 4 October 2023

OCA — Wed, 04 Oct 2023 13:58:14 GMT

←Older revision		Revision as of 13:58, 4 October 2023
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	<StructureSection load='5vtm' size='340' side='right'caption='[[5vtm]], [[Resolution\|resolution]] 2.04Å' scene=''>		<StructureSection load='5vtm' size='340' side='right'caption='[[5vtm]], [[Resolution\|resolution]] 2.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5vtm]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pseae Pseae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VTM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5VTM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5vtm]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VTM FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CA:CALCIUM+ION'>CA</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.041Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~MSE~~:~~SELENOMETHIONINE~~'>~~MSE~~</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><td class="sblockDat">xcpW, pddD, PA3098 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE]), xcpX, PA3097 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE]), xcpV, pddC, PA3099 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vtm OCA], [https://pdbe.org/5vtm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vtm RCSB], [https://www.ebi.ac.uk/pdbsum/5vtm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vtm ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5vtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vtm OCA], [~~http~~://pdbe.org/5vtm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5vtm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5vtm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5vtm ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GSPJ_PSEAE GSPJ_PSEAE]] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for the translocation of a variety of enzymes across the outer membrane. [[http://www.uniprot.org/uniprot/GSPI_PSEAE GSPI_PSEAE]] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for the translocation of a variety of enzymes across the outer membrane. [[http://www.uniprot.org/uniprot/GSPK_PSEAE GSPK_PSEAE]] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.	+	[https://www.uniprot.org/uniprot/GSPJ_PSEAE GSPJ_PSEAE] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for the translocation of a variety of enzymes across the outer membrane.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5vtm" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5vtm" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Pseudopilin\|Pseudopilin]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pseae~~]]	+	[[Category: Pseudomonas aeruginosa PAO1]]
-	[[Category: Jia, Z]]	+	[[Category: Jia Z]]
-	[[Category: Zhang, Y]]	+	[[Category: Zhang Y]]
-	~~[[Category: Transport protein]]~~	+
-	~~[[Category: Type 2 secretion system~~]]	+

OCA at 07:24, 6 November 2019

OCA — Wed, 06 Nov 2019 07:24:48 GMT

←Older revision		Revision as of 07:24, 6 November 2019
Line 1:		Line 1:

	==The crystal structure of minor pseudopilin ternary complex of XcpVWX from the Type 2 secretion system of Pseudomonas aeruginosa==		==The crystal structure of minor pseudopilin ternary complex of XcpVWX from the Type 2 secretion system of Pseudomonas aeruginosa==
-	<StructureSection load='5vtm' size='340' side='right' caption='[[5vtm]], [[Resolution\|resolution]] 2.04Å' scene=''>	+	<StructureSection load='5vtm' size='340' side='right'caption='[[5vtm]], [[Resolution\|resolution]] 2.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5vtm]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VTM FirstGlance]. <br>		<table><tr><td colspan='2'>[[5vtm]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VTM FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Pseae]]		[[Category: Pseae]]
	[[Category: Jia, Z]]		[[Category: Jia, Z]]

OCA at 12:33, 7 November 2018

OCA — Wed, 07 Nov 2018 12:33:38 GMT

←Older revision		Revision as of 12:33, 7 November 2018
Line 3:		Line 3:
	<StructureSection load='5vtm' size='340' side='right' caption='[[5vtm]], [[Resolution\|resolution]] 2.04Å' scene=''>		<StructureSection load='5vtm' size='340' side='right' caption='[[5vtm]], [[Resolution\|resolution]] 2.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5vtm]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VTM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5vtm]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VTM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">xcpW, pddD, PA3098 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE]), xcpX, PA3097 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE]), xcpV, pddC, PA3099 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vtm OCA], [http://pdbe.org/5vtm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vtm RCSB], [http://www.ebi.ac.uk/pdbsum/5vtm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vtm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vtm OCA], [http://pdbe.org/5vtm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vtm RCSB], [http://www.ebi.ac.uk/pdbsum/5vtm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vtm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/GSPJ_PSEAE GSPJ_PSEAE]] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for the translocation of a variety of enzymes across the outer membrane. [[http://www.uniprot.org/uniprot/GSPI_PSEAE GSPI_PSEAE]] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for the translocation of a variety of enzymes across the outer membrane. [[http://www.uniprot.org/uniprot/GSPK_PSEAE GSPK_PSEAE]] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.		[[http://www.uniprot.org/uniprot/GSPJ_PSEAE GSPJ_PSEAE]] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for the translocation of a variety of enzymes across the outer membrane. [[http://www.uniprot.org/uniprot/GSPI_PSEAE GSPI_PSEAE]] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for the translocation of a variety of enzymes across the outer membrane. [[http://www.uniprot.org/uniprot/GSPK_PSEAE GSPK_PSEAE]] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pseudomonas aeruginosa utilizes the Type II secretion system (T2SS) to translocate a wide range of large, structured protein virulence factors through the periplasm to the extracellular environment for infection. In the T2SS, five pseudopilins assemble into the pseudopilus that acts as a piston to extrude exoproteins out of cells. Through structure determination of the pseudopilin complexes of XcpVWX and XcpVW and function analysis, we have confirmed that two minor pseudopilins, XcpV and XcpW, constitute a core complex indispensable to the pseudopilus tip. The absence of either XcpV or -W resulted in the non-functional T2SS. Our small-angle X-ray scattering experiment for the first time revealed the architecture of the entire pseudopilus tip and established the working model. Based on the interaction interface of complexes, we have developed inhibitory peptides. The structure-based peptides not only disrupted of the XcpVW core complex and the entire pseudopilus tip in vitro but also inhibited the T2SS in vivo. More importantly, these peptides effectively reduced the virulence of P. aeruginosa towards Caenorhabditis elegans.
		+
		+	Structure-guided disruption of the pseudopilus tip complex inhibits the Type II secretion in Pseudomonas aeruginosa.,Zhang Y, Faucher F, Zhang W, Wang S, Neville N, Poole K, Zheng J, Jia Z PLoS Pathog. 2018 Oct 22;14(10):e1007343. doi: 10.1371/journal.ppat.1007343., eCollection 2018 Oct. PMID:30346996<ref>PMID:30346996</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5vtm" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Pseae]]
	[[Category: Jia, Z]]		[[Category: Jia, Z]]
	[[Category: Zhang, Y]]		[[Category: Zhang, Y]]
	[[Category: Transport protein]]		[[Category: Transport protein]]
	[[Category: Type 2 secretion system]]		[[Category: Type 2 secretion system]]

OCA at 07:14, 23 May 2018

OCA — Wed, 23 May 2018 07:14:40 GMT

←Older revision		Revision as of 07:14, 23 May 2018
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-	'''Unreleased structure'''

-	The ~~entry~~ 5vtm is ~~ON HOLD until Paper Publication~~	+	==The crystal structure of minor pseudopilin ternary complex of XcpVWX from the Type 2 secretion system of Pseudomonas aeruginosa==
-		+	<StructureSection load='5vtm' size='340' side='right' caption='[[5vtm]], [[Resolution\|resolution]] 2.04Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5vtm]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VTM FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vtm OCA], [http://pdbe.org/5vtm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vtm RCSB], [http://www.ebi.ac.uk/pdbsum/5vtm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vtm ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GSPJ_PSEAE GSPJ_PSEAE]] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for the translocation of a variety of enzymes across the outer membrane. [[http://www.uniprot.org/uniprot/GSPI_PSEAE GSPI_PSEAE]] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for the translocation of a variety of enzymes across the outer membrane. [[http://www.uniprot.org/uniprot/GSPK_PSEAE GSPK_PSEAE]] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Jia, Z]]
		+	[[Category: Zhang, Y]]
		+	[[Category: Transport protein]]
		+	[[Category: Type 2 secretion system]]

OCA at 14:13, 27 September 2017

OCA — Wed, 27 Sep 2017 14:13:12 GMT

←Older revision		Revision as of 14:13, 27 September 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5vtm is ON HOLD	+	The entry 5vtm is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5vtm" [edit=sysop:move=sysop]

OCA — Wed, 24 May 2017 11:49:24 GMT

Protected "5vtm" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:49, 24 May 2017

OCA: New page: '''Unreleased structure''' The entry 5vtm is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 24 May 2017 11:49:23 GMT

New page: '''Unreleased structure''' The entry 5vtm is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5vtm is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]