5vwf - Revision history

OCA at 14:00, 4 October 2023

OCA — Wed, 04 Oct 2023 14:00:44 GMT

←Older revision		Revision as of 14:00, 4 October 2023
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	<StructureSection load='5vwf' size='340' side='right'caption='[[5vwf]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='5vwf' size='340' side='right'caption='[[5vwf]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5vwf]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VWF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5VWF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5vwf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VWF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VWF FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5vud\|5vud]], [[5vue\|5vue]], [[5vuf\|5vuf]], [[5vvp\|5vvp]], [[5vwd\|5vwd]], [[5vwh\|5vwh]], [[5vwj\|5vwj]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">HLA-B ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vwf OCA], [https://pdbe.org/5vwf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vwf RCSB], [https://www.ebi.ac.uk/pdbsum/5vwf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vwf ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5vwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vwf OCA], [~~http~~://pdbe.org/5vwf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5vwf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5vwf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5vwf ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[~~http~~://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>	+	[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
	== Function ==		== Function ==
-	[~~[http://www.uniprot.org/uniprot/I3ZN84_HUMAN I3ZN84_HUMAN]] Involved in the presentation of foreign antigens to the immune system.[SAAS:SAAS00291881] [[http~~://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	+	[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pymm, P~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Rossjohn, J~~]]	+	[[Category: Pymm P]]
-	[[Category: ~~Vivian,~~ J P]]	+	[[Category: Rossjohn J]]
-	[[Category: ~~Antigen presentation]]~~	+	[[Category: Vivian JP]]
-	~~[[Category: Human leukocyte antigen]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 06:30, 17 April 2019

OCA — Wed, 17 Apr 2019 06:30:38 GMT

←Older revision		Revision as of 06:30, 17 April 2019
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	==HLA-B*58:03 presenting LTVQVARVY==		==HLA-B*58:03 presenting LTVQVARVY==
-	<StructureSection load='5vwf' size='340' side='right' caption='[[5vwf]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='5vwf' size='340' side='right'caption='[[5vwf]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5vwf]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VWF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VWF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5vwf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VWF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VWF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vud\|5vud]], [[5vue\|5vue]], [[5vuf\|5vuf]], [[5vvp\|5vvp]], [[5vwd\|5vwd]], [[5vwh\|5vwh]], [[5vwj\|5vwj]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vud\|5vud]], [[5vue\|5vue]], [[5vuf\|5vuf]], [[5vvp\|5vvp]], [[5vwd\|5vwd]], [[5vwh\|5vwh]], [[5vwj\|5vwj]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA-B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vwf OCA], [http://pdbe.org/5vwf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vwf RCSB], [http://www.ebi.ac.uk/pdbsum/5vwf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vwf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vwf OCA], [http://pdbe.org/5vwf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vwf RCSB], [http://www.ebi.ac.uk/pdbsum/5vwf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vwf ProSAT]</span></td></tr>
	</table>		</table>
Line 11:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/I3ZN84_HUMAN I3ZN84_HUMAN]] Involved in the presentation of foreign antigens to the immune system.[SAAS:SAAS00291881] [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.		[[http://www.uniprot.org/uniprot/I3ZN84_HUMAN I3ZN84_HUMAN]] Involved in the presentation of foreign antigens to the immune system.[SAAS:SAAS00291881] [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Immunophenotypic differences between closely related human leukocyte antigen (HLA) alleles have been associated with divergent clinical outcomes in infection, autoimmunity, transplantation and drug hypersensitivity. Here we explore the impact of micropolymorphism on peptide antigen presentation by three closely related HLA molecules, HLA-B57:01, HLA-B57:03 and HLA-B*58:01, that are differentially associated with the HIV elite controller phenotype and adverse drug reactions. For each allotype, we mine HLA ligand data sets derived from the same parental cell proteome to define qualitative differences in peptide presentation using classical peptide binding motifs and an unbiased statistical approach. The peptide repertoires show marked qualitative overlap, with 982 peptides presented by all allomorphs. However, differences in peptide abundance, HLA-peptide stability, and HLA-bound conformation demonstrate that HLA micropolymorphism impacts more than simply the range of peptide ligands. These differences provide grounds for distinct immune reactivity and insights into the capacity of micropolymorphism to diversify immune outcomes.
		+
		+	HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome.,Illing PT, Pymm P, Croft NP, Hilton HG, Jojic V, Han AS, Mendoza JL, Mifsud NA, Dudek NL, McCluskey J, Parham P, Rossjohn J, Vivian JP, Purcell AW Nat Commun. 2018 Nov 8;9(1):4693. doi: 10.1038/s41467-018-07109-w. PMID:30410026<ref>PMID:30410026</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5vwf" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Pymm, P]]		[[Category: Pymm, P]]
	[[Category: Rossjohn, J]]		[[Category: Rossjohn, J]]

OCA at 07:37, 3 October 2018

OCA — Wed, 03 Oct 2018 07:37:20 GMT

←Older revision		Revision as of 07:37, 3 October 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5vwf is ~~ON HOLD~~ ~~until Paper Publication~~	+	==HLA-B*58:03 presenting LTVQVARVY==
-		+	<StructureSection load='5vwf' size='340' side='right' caption='[[5vwf]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5vwf]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VWF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VWF FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vud\|5vud]], [[5vue\|5vue]], [[5vuf\|5vuf]], [[5vvp\|5vvp]], [[5vwd\|5vwd]], [[5vwh\|5vwh]], [[5vwj\|5vwj]]</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vwf OCA], [http://pdbe.org/5vwf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vwf RCSB], [http://www.ebi.ac.uk/pdbsum/5vwf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vwf ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/I3ZN84_HUMAN I3ZN84_HUMAN]] Involved in the presentation of foreign antigens to the immune system.[SAAS:SAAS00291881] [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Pymm, P]]
		+	[[Category: Rossjohn, J]]
		+	[[Category: Vivian, J P]]
		+	[[Category: Antigen presentation]]
		+	[[Category: Human leukocyte antigen]]
		+	[[Category: Immune system]]

OCA: Protected "5vwf" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 14:14:47 GMT

Protected "5vwf" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:14, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5vwf is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Sep 2017 14:14:46 GMT

New page: '''Unreleased structure''' The entry 5vwf is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5vwf is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]