5w2u - Revision history

OCA at 14:05, 4 October 2023

OCA — Wed, 04 Oct 2023 14:05:51 GMT

←Older revision		Revision as of 14:05, 4 October 2023
Line 1:		Line 1:

	==INFLUENZA VIRUS NEURAMINIDASE N9 IN COMPLEX WITH 7-DEOXYGENATED 2,3-DIFLUORO-N-ACETYLNEURAMINIC ACID==		==INFLUENZA VIRUS NEURAMINIDASE N9 IN COMPLEX WITH 7-DEOXYGENATED 2,3-DIFLUORO-N-ACETYLNEURAMINIC ACID==
-	<StructureSection load='5w2u' size='340' side='right' caption='[[5w2u]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='5w2u' size='340' side='right'caption='[[5w2u]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5w2u]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~I75a5 I75a5~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W2U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5W2U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5w2u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/tern/Australia/G70C/1975(H11N9)) Influenza A virus (A/tern/Australia/G70C/1975(H11N9))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W2U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5W2U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9S4:(2~{S},3~{R},4~{R},5~{R})-3-acetamido-2-[(2~{S})-2,3-bis(oxidanyl)propyl]-5-fluoranyl-4-oxidanyl-2,3,4,5-tetrahydropyran-1-ium-6-carboxylic+acid'>9S4</scene>, <scene name='pdbligand=9SJ:5-~~(acetylamino)~~-2,6-anhydro-3,5,7-trideoxy-3-fluoro-D-threo-L-galacto-nononic+acid'>9SJ</scene>, <scene name='pdbligand=9SM:(~~2~{R}~~,~~3~{R}~~,~~4~{R}~~,~~5~{R}~~,~~6~{S}~~)-5-acetamido-6-[(~~2~{S}~~)-2,3-bis(oxidanyl)propyl]-2,3-bis(fluoranyl)-4-oxidanyl-oxane-2-carboxylic+acid'>9SM</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5w26\|5w26]], [[5w2w\|5w2w]], [[5w2y\|5w2y]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9S4:(2~{S},3~{R},4~{R},5~{R})-3-acetamido-2-[(2~{S})-2,3-bis(oxidanyl)propyl]-5-fluoranyl-4-oxidanyl-2,3,4,5-tetrahydropyran-1-ium-6-carboxylic+acid'>9S4</scene>, <scene name='pdbligand=9SJ:5-acetamido-2,6-anhydro-3,5,7-trideoxy-3-fluoro-D-threo-L-galacto-nononic+acid'>9SJ</scene>, <scene name='pdbligand=9SM:(2R,3R,4R,5R,6S)-5-acetamido-6-[(2S)-2,3-bis(oxidanyl)propyl]-2,3-bis(fluoranyl)-4-oxidanyl-oxane-2-carboxylic+acid'>9SM</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=384509 I75A5])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5w2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w2u OCA], [https://pdbe.org/5w2u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5w2u RCSB], [https://www.ebi.ac.uk/pdbsum/5w2u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5w2u ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5w2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w2u OCA], [~~http~~://pdbe.org/5w2u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5w2u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5w2u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5w2u ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NRAM_I75A5 NRAM_I75A5]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.	+	[https://www.uniprot.org/uniprot/NRAM_I75A5 NRAM_I75A5] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5w2u" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5w2u" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Exo-alpha-sialidase]]~~	+	[[Category: Large Structures]]
-	~~[[Category: I75a5~~]]	+	[[Category: Barrett S]]
-	[[Category: Barrett, S]]	+	[[Category: Hader S]]
-	[[Category: Hader, S]]	+	[[Category: Mckimm-Breschkin J]]
-	[[Category: Mckimm-Breschkin, J]]	+	[[Category: Pilling P]]
-	[[Category: Pilling, P]]	+	[[Category: Streltsov VA]]
-	[[Category: Streltsov~~, V A~~]]	+	[[Category: Watt AG]]
-	[[Category: Watt~~, A G]]~~	+
-	~~[[Category: 3-difluorosialic acid]]~~	+
-	~~[[Category: 7-deoxy 2]]~~	+
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Influenza virus neuraminidase]]~~	+
-	~~[[Category: N9]]~~	+
-	~~[[Category: Second binding site~~]]	+

OCA at 07:55, 21 March 2018

OCA — Wed, 21 Mar 2018 07:55:34 GMT

←Older revision		Revision as of 07:55, 21 March 2018
Line 3:		Line 3:
	<StructureSection load='5w2u' size='340' side='right' caption='[[5w2u]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5w2u' size='340' side='right' caption='[[5w2u]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5w2u]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W2U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W2U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5w2u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/I75a5 I75a5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W2U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W2U FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9S4:(2~{S},3~{R},4~{R},5~{R})-3-acetamido-2-[(2~{S})-2,3-bis(oxidanyl)propyl]-5-fluoranyl-4-oxidanyl-2,3,4,5-tetrahydropyran-1-ium-6-carboxylic+acid'>9S4</scene>, <scene name='pdbligand=9SJ:5-(acetylamino)-2,6-anhydro-3,5,7-trideoxy-3-fluoro-D-threo-L-galacto-nononic+acid'>9SJ</scene>, <scene name='pdbligand=9SM:(2~{R},3~{R},4~{R},5~{R},6~{S})-5-acetamido-6-[(2~{S})-2,3-bis(oxidanyl)propyl]-2,3-bis(fluoranyl)-4-oxidanyl-oxane-2-carboxylic+acid'>9SM</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9S4:(2~{S},3~{R},4~{R},5~{R})-3-acetamido-2-[(2~{S})-2,3-bis(oxidanyl)propyl]-5-fluoranyl-4-oxidanyl-2,3,4,5-tetrahydropyran-1-ium-6-carboxylic+acid'>9S4</scene>, <scene name='pdbligand=9SJ:5-(acetylamino)-2,6-anhydro-3,5,7-trideoxy-3-fluoro-D-threo-L-galacto-nononic+acid'>9SJ</scene>, <scene name='pdbligand=9SM:(2~{R},3~{R},4~{R},5~{R},6~{S})-5-acetamido-6-[(2~{S})-2,3-bis(oxidanyl)propyl]-2,3-bis(fluoranyl)-4-oxidanyl-oxane-2-carboxylic+acid'>9SM</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5w26\|5w26]], [[5w2w\|5w2w]], [[5w2y\|5w2y]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5w26\|5w26]], [[5w2w\|5w2w]], [[5w2y\|5w2y]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=384509 I75A5])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w2u OCA], [http://pdbe.org/5w2u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w2u RCSB], [http://www.ebi.ac.uk/pdbsum/5w2u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w2u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w2u OCA], [http://pdbe.org/5w2u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w2u RCSB], [http://www.ebi.ac.uk/pdbsum/5w2u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w2u ProSAT]</span></td></tr>
Line 25:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
		+	[[Category: I75a5]]
	[[Category: Barrett, S]]		[[Category: Barrett, S]]
	[[Category: Hader, S]]		[[Category: Hader, S]]

OCA at 07:17, 22 February 2018

OCA — Thu, 22 Feb 2018 07:17:33 GMT

←Older revision		Revision as of 07:17, 22 February 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5w2u is ~~ON HOLD until Paper~~ Publication	+	==INFLUENZA VIRUS NEURAMINIDASE N9 IN COMPLEX WITH 7-DEOXYGENATED 2,3-DIFLUORO-N-ACETYLNEURAMINIC ACID==
		+	<StructureSection load='5w2u' size='340' side='right' caption='[[5w2u]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5w2u]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W2U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W2U FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9S4:(2~{S},3~{R},4~{R},5~{R})-3-acetamido-2-[(2~{S})-2,3-bis(oxidanyl)propyl]-5-fluoranyl-4-oxidanyl-2,3,4,5-tetrahydropyran-1-ium-6-carboxylic+acid'>9S4</scene>, <scene name='pdbligand=9SJ:5-(acetylamino)-2,6-anhydro-3,5,7-trideoxy-3-fluoro-D-threo-L-galacto-nononic+acid'>9SJ</scene>, <scene name='pdbligand=9SM:(2~{R},3~{R},4~{R},5~{R},6~{S})-5-acetamido-6-[(2~{S})-2,3-bis(oxidanyl)propyl]-2,3-bis(fluoranyl)-4-oxidanyl-oxane-2-carboxylic+acid'>9SM</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5w26\|5w26]], [[5w2w\|5w2w]], [[5w2y\|5w2y]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w2u OCA], [http://pdbe.org/5w2u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w2u RCSB], [http://www.ebi.ac.uk/pdbsum/5w2u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w2u ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NRAM_I75A5 NRAM_I75A5]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Competitive inhibitors of the influenza neuraminidase (NA) were discovered almost 20 years ago, with zanamivir and oseltamivir licensed globally. These compounds are based on a transition state analogue of the sialic acid substrate. We recently showed that 5-N-(acetylamino)-2,3,5-trideoxy-2,3-difluoro-d-erythro-beta-l-manno-2-nonulopyra nosonic acid (DFSA) and its derivatives are also potent inhibitors of the influenza NA. They are mechanism based inhibitors, forming a covalent bond between the C2 of the sugar ring and Y406 in the NA active site, thus inactivating the enzyme. We have now synthesized a series of deoxygenated DFSA derivatives in order to understand the contribution of each hydroxyl in DFSA to binding and inhibition of the influenza NA. We have investigated their relative efficacy in enzyme assays in vitro, in cell culture, and by X-ray crystallography. We found loss of the 8- and 9-OH had the biggest impact on the affinity of binding and antiviral potency.

-	~~Authors: Streltsov~~, ~~V.A.~~, ~~Mckimm~~-~~Breschkin~~, J., ~~Barrett~~, S., Pilling~~, P.~~, Hader, S., ~~Watt~~, A.G.	+	Structural and Functional Analysis of Anti-Influenza Activity of 4-, 7-, 8- and 9-Deoxygenated 2,3-Difluoro-N-acetylneuraminic Acid Derivatives.,McKimm-Breschkin JL, Barrett S, Pilling PA, Hader S, Watts AG, Streltsov VA J Med Chem. 2018 Feb 15. doi: 10.1021/acs.jmedchem.7b01467. PMID:29397718<ref>PMID:29397718</ref>

-	~~Description: INFLUENZA VIRUS NEURAMINIDASE N9 IN COMPLEX WITH 7-DEOXYGENATED 2~~,3-~~DIFLUORO~~-~~N-ACETYLNEURAMINIC ACID~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Watt, A.G~~]]	+	<div class="pdbe-citations 5w2u" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Exo-alpha-sialidase]]
	[[Category: Barrett, S]]		[[Category: Barrett, S]]
-	[[Category: Pilling, P]]
-	[[Category: Mckimm-Breschkin, J]]
	[[Category: Hader, S]]		[[Category: Hader, S]]
-	[[Category: Streltsov, V.A]]	+	[[Category: Mckimm-Breschkin, J]]
		+	[[Category: Pilling, P]]
		+	[[Category: Streltsov, V A]]
		+	[[Category: Watt, A G]]
		+	[[Category: 3-difluorosialic acid]]
		+	[[Category: 7-deoxy 2]]
		+	[[Category: Complex]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Influenza virus neuraminidase]]
		+	[[Category: N9]]
		+	[[Category: Second binding site]]

OCA: Protected "5w2u" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 14:23:25 GMT

Protected "5w2u" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:23, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5w2u is ON HOLD until Paper Publication Authors: Streltsov, V.A., Mckimm-Breschkin, J., Barrett, S., Pilling, P., Hader, S., Watt, A.G. Description...

OCA — Wed, 27 Sep 2017 14:23:23 GMT

New page: '''Unreleased structure''' The entry 5w2u is ON HOLD until Paper Publication Authors: Streltsov, V.A., Mckimm-Breschkin, J., Barrett, S., Pilling, P., Hader, S., Watt, A.G. Description...

New page

'''Unreleased structure'''

The entry 5w2u is ON HOLD until Paper Publication

Authors: Streltsov, V.A., Mckimm-Breschkin, J., Barrett, S., Pilling, P., Hader, S., Watt, A.G.

Description: INFLUENZA VIRUS NEURAMINIDASE N9 IN COMPLEX WITH 7-DEOXYGENATED 2,3-DIFLUORO-N-ACETYLNEURAMINIC ACID
[[Category: Unreleased Structures]]
[[Category: Watt, A.G]]
[[Category: Barrett, S]]
[[Category: Pilling, P]]
[[Category: Mckimm-Breschkin, J]]
[[Category: Hader, S]]
[[Category: Streltsov, V.A]]