5w94 - Revision history

OCA at 14:09, 4 October 2023

OCA — Wed, 04 Oct 2023 14:09:09 GMT

←Older revision		Revision as of 14:09, 4 October 2023
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	<StructureSection load='5w94' size='340' side='right'caption='[[5w94]], [[Resolution\|resolution]] 3.19Å' scene=''>		<StructureSection load='5w94' size='340' side='right'caption='[[5w94]], [[Resolution\|resolution]] 3.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5w94]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W94 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5W94 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5w94]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5W94 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=SEP:PHOSPHOSERINE'>SEP</scene~~>, ~~<scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.193Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[4xdn\|4xdn]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td><~~td class~~=~~"sblockDat">SCC4, YER147C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode=5&id=4932 ATCC 18824]), SCC2, YDR180W, YD9395.14 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5w94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w94 OCA], [https://pdbe.org/5w94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5w94 RCSB], [https://www.ebi.ac.uk/pdbsum/5w94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5w94 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5w94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w94 OCA], [~~http~~://pdbe.org/5w94 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5w94 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5w94 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5w94 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SCC4_YEAST SCC4_YEAST]] Involved in sister chromatid cohesion. Forms a complex with SCC2, which is required for the association of the cohesin complex with chromosomes.<ref>PMID:10882066</ref> [[http://www.uniprot.org/uniprot/SCC2_YEAST SCC2_YEAST]] Plays a structural role in chromatin. Involved in sister chromatid cohesion. Forms a complex with SCC4 required for the stable association of the cohesin complex with chromatin, which may act by hydrolyzing ATP from SMC1 and SMC3 heads. Also participates in DNA repair.<ref>PMID:10882066</ref> <ref>PMID:14614819</ref>	+	[https://www.uniprot.org/uniprot/SCC4_YEAST SCC4_YEAST] Involved in sister chromatid cohesion. Forms a complex with SCC2, which is required for the association of the cohesin complex with chromosomes.<ref>PMID:10882066</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Harrison, S C~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Hinshaw, S M~~]]	+	[[Category: Harrison SC]]
-	[[Category: ~~Cell cycle]]~~	+	[[Category: Hinshaw SM]]
-	~~[[Category: Centromere]]~~	+
-	~~[[Category: Cohesin]]~~	+
-	~~[[Category: Kinetochore~~]]	+

OCA at 16:59, 20 November 2019

OCA — Wed, 20 Nov 2019 16:59:29 GMT

←Older revision		Revision as of 16:59, 20 November 2019
Line 1:		Line 1:

	==Crystal structure of Scc4 in complex with Scc2n and Ctf19n==		==Crystal structure of Scc4 in complex with Scc2n and Ctf19n==
-	<StructureSection load='5w94' size='340' side='right' caption='[[5w94]], [[Resolution\|resolution]] 3.19Å' scene=''>	+	<StructureSection load='5w94' size='340' side='right'caption='[[5w94]], [[Resolution\|resolution]] 3.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5w94]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W94 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5w94]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W94 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xdn\|4xdn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xdn\|4xdn]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCC4, YER147C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), SCC2, YDR180W, YD9395.14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w94 OCA], [http://pdbe.org/5w94 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w94 RCSB], [http://www.ebi.ac.uk/pdbsum/5w94 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w94 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w94 OCA], [http://pdbe.org/5w94 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w94 RCSB], [http://www.ebi.ac.uk/pdbsum/5w94 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w94 ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Harrison, S C]]		[[Category: Harrison, S C]]
	[[Category: Hinshaw, S M]]		[[Category: Hinshaw, S M]]

OCA at 09:18, 4 October 2017

OCA — Wed, 04 Oct 2017 09:18:25 GMT

←Older revision		Revision as of 09:18, 4 October 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5w94 is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of Scc4 in complex with Scc2n and Ctf19n==
		+	<StructureSection load='5w94' size='340' side='right' caption='[[5w94]], [[Resolution\|resolution]] 3.19Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5w94]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W94 FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xdn\|4xdn]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w94 OCA], [http://pdbe.org/5w94 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w94 RCSB], [http://www.ebi.ac.uk/pdbsum/5w94 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w94 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SCC4_YEAST SCC4_YEAST]] Involved in sister chromatid cohesion. Forms a complex with SCC2, which is required for the association of the cohesin complex with chromosomes.<ref>PMID:10882066</ref> [[http://www.uniprot.org/uniprot/SCC2_YEAST SCC2_YEAST]] Plays a structural role in chromatin. Involved in sister chromatid cohesion. Forms a complex with SCC4 required for the stable association of the cohesin complex with chromatin, which may act by hydrolyzing ATP from SMC1 and SMC3 heads. Also participates in DNA repair.<ref>PMID:10882066</ref> <ref>PMID:14614819</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The ring-shaped cohesin complex brings together distant DNA domains to maintain, express, and segregate the genome. Establishing specific chromosomal linkages depends on cohesin recruitment to defined loci. One such locus is the budding yeast centromere, which is a paradigm for targeted cohesin loading. The kinetochore, a multiprotein complex that connects centromeres to microtubules, drives the recruitment of high levels of cohesin to link sister chromatids together. We have exploited this system to determine the mechanism of specific cohesin recruitment. We show that phosphorylation of the Ctf19 kinetochore protein by a conserved kinase, DDK, provides a binding site for the Scc2/4 cohesin loading complex, thereby directing cohesin loading to centromeres. A similar mechanism targets cohesin to chromosomes in vertebrates. These findings represent a complete molecular description of targeted cohesin loading, a phenomenon with wide-ranging importance in chromosome segregation and, in multicellular organisms, transcription regulation.

-	~~Authors~~:	+	The Kinetochore Receptor for the Cohesin Loading Complex.,Hinshaw SM, Makrantoni V, Harrison SC, Marston AL Cell. 2017 Sep 21;171(1):72-84.e13. doi: 10.1016/j.cell.2017.08.017. PMID:28938124<ref>PMID:28938124</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5w94" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Harrison, S C]]
		+	[[Category: Hinshaw, S M]]
		+	[[Category: Cell cycle]]
		+	[[Category: Centromere]]
		+	[[Category: Cohesin]]
		+	[[Category: Kinetochore]]

OCA: Protected "5w94" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 14:35:12 GMT

Protected "5w94" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:35, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5w94 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Sep 2017 14:35:10 GMT

New page: '''Unreleased structure''' The entry 5w94 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5w94 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]