5wi1 - Revision history

OCA at 14:13, 4 October 2023

OCA — Wed, 04 Oct 2023 14:13:39 GMT

←Older revision		Revision as of 14:13, 4 October 2023
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	<StructureSection load='5wi1' size='340' side='right'caption='[[5wi1]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='5wi1' size='340' side='right'caption='[[5wi1]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wi1]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WI1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5WI1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wi1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WI1 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=AOY:(3E)-3~~-[~~(phenylamino)methylidene~~]~~oxan-2-one'>AOY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.99Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>NAMPT, PBEF, PBEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AOY:(3E)-3-[(phenylamino)methylidene]oxan-2-one'>AOY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wi1 OCA], [https://pdbe.org/5wi1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wi1 RCSB], [https://www.ebi.ac.uk/pdbsum/5wi1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wi1 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5wi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wi1 OCA], [~~http~~://pdbe.org/5wi1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5wi1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5wi1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5wi1 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).	+	[https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5wi1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5wi1" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phosphoribosyltransferase 3D structures\|Phosphoribosyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Nicotinamide phosphoribosyltransferase]]~~	+	[[Category: Korepanova AV]]
-	[[Category: Korepanova~~, A V~~]]	+	[[Category: Longenecker KL]]
-	[[Category: Longenecker~~, K L~~]]	+	[[Category: Raich D]]
-	[[Category: Raich, D]]	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Nampt]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 09:01, 1 May 2019

OCA — Wed, 01 May 2019 09:01:40 GMT

←Older revision		Revision as of 09:01, 1 May 2019
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	==Crystal structure of human NAMPT with fragment 5: (3E)-3-[(phenylamino)methylidene]oxan-2-one==		==Crystal structure of human NAMPT with fragment 5: (3E)-3-[(phenylamino)methylidene]oxan-2-one==
-	<StructureSection load='5wi1' size='340' side='right' caption='[[5wi1]], [[Resolution\|resolution]] 1.99Å' scene=''>	+	<StructureSection load='5wi1' size='340' side='right'caption='[[5wi1]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5wi1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WI1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5wi1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WI1 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Nicotinamide phosphoribosyltransferase]]		[[Category: Nicotinamide phosphoribosyltransferase]]
	[[Category: Korepanova, A V]]		[[Category: Korepanova, A V]]

OCA at 07:56, 21 March 2018

OCA — Wed, 21 Mar 2018 07:56:19 GMT

←Older revision		Revision as of 07:56, 21 March 2018
Line 3:		Line 3:
	<StructureSection load='5wi1' size='340' side='right' caption='[[5wi1]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='5wi1' size='340' side='right' caption='[[5wi1]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wi1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WI1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wi1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WI1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AOY:(3E)-3-[(phenylamino)methylidene]oxan-2-one'>AOY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AOY:(3E)-3-[(phenylamino)methylidene]oxan-2-one'>AOY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NAMPT, PBEF, PBEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wi1 OCA], [http://pdbe.org/5wi1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wi1 RCSB], [http://www.ebi.ac.uk/pdbsum/5wi1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wi1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wi1 OCA], [http://pdbe.org/5wi1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wi1 RCSB], [http://www.ebi.ac.uk/pdbsum/5wi1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wi1 ProSAT]</span></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Nicotinamide phosphoribosyltransferase]]		[[Category: Nicotinamide phosphoribosyltransferase]]
	[[Category: Korepanova, A V]]		[[Category: Korepanova, A V]]

OCA at 08:28, 10 January 2018

OCA — Wed, 10 Jan 2018 08:28:41 GMT

←Older revision		Revision as of 08:28, 10 January 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5wi1 is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of human NAMPT with fragment 5: (3E)-3-[(phenylamino)methylidene]oxan-2-one==
		+	<StructureSection load='5wi1' size='340' side='right' caption='[[5wi1]], [[Resolution\|resolution]] 1.99Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5wi1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WI1 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AOY:(3E)-3-[(phenylamino)methylidene]oxan-2-one'>AOY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wi1 OCA], [http://pdbe.org/5wi1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wi1 RCSB], [http://www.ebi.ac.uk/pdbsum/5wi1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wi1 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	NAMPT expression is elevated in many cancers, making this protein a potential target for anticancer therapy. We have carried out both NMR based and TR-FRET based fragment screens against human NAMPT and identified six novel binders with a range of potencies. Co-crystal structures were obtained for two of the fragments bound to NAMPT while for the other four fragments force-field driven docking was employed to generate a bound pose. Based on structural insights arising from comparison of the bound fragment poses to that of bound FK866 we were able to synthetically elaborate one of the fragments into a potent NAMPT inhibitor.

-	~~Authors~~:	+	Fragment-based discovery of a potent NAMPT inhibitor.,Korepanova A, Longenecker KL, Pratt SD, Panchal SC, Clark RF, Lake M, Gopalakrishnan SM, Raich D, Sun C, Petros AM Bioorg Med Chem Lett. 2017 Dec 12. pii: S0960-894X(17)31183-6. doi:, 10.1016/j.bmcl.2017.12.023. PMID:29287958<ref>PMID:29287958</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5wi1" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Nicotinamide phosphoribosyltransferase]]
		+	[[Category: Korepanova, A V]]
		+	[[Category: Longenecker, K L]]
		+	[[Category: Raich, D]]
		+	[[Category: Inhibitor]]
		+	[[Category: Nampt]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA: Protected "5wi1" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 14:50:31 GMT

Protected "5wi1" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:50, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5wi1 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Sep 2017 14:50:30 GMT

New page: '''Unreleased structure''' The entry 5wi1 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5wi1 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]