5wkg - Revision history

OCA at 08:53, 30 September 2020

OCA — Wed, 30 Sep 2020 08:53:18 GMT

←Older revision		Revision as of 08:53, 30 September 2020
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	==Crystal Structure of Human CD1b in Complex with PA==		==Crystal Structure of Human CD1b in Complex with PA==
-	<StructureSection load='5wkg' size='340' side='right' caption='[[5wkg]], [[Resolution\|resolution]] 2.06Å' scene=''>	+	<StructureSection load='5wkg' size='340' side='right'caption='[[5wkg]], [[Resolution\|resolution]] 2.06Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wkg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WKG OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5WKG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wkg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WKG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5WKG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CUY:tetracosyl+octadecanoate'>CUY</scene>, <scene name='pdbligand=D21:(2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl+(9Z)-octadec-9-enoate'>D21</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=~~FUC~~:~~ALPHA-L-FUCOSE~~'>~~FUC~~</scene>, <scene name='pdbligand=~~IOD~~:~~IODIDE~~+ION'>~~IOD~~</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA~~-D-~~MANNOSE~~'>~~MAN~~</scene>, <scene name='pdbligand=NA:~~SODIUM+ION~~'>NA</scene>, <scene name='pdbligand=~~NAG~~:N-~~ACETYL~~-~~D-GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~PEG~~:~~DI(HYDROXYETHYL)ETHER~~'>~~PEG~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CUY:tetracosyl+octadecanoate'>CUY</scene>, <scene name='pdbligand=D21:(2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl+(9Z)-octadec-9-enoate'>D21</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca.weizmann~~.~~ac.il/oca-docs~~/fgij/fg.htm?mol=5wkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wkg OCA], [http://pdbe.org/5wkg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wkg RCSB], [http://www.ebi.ac.uk/pdbsum/5wkg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wkg ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5wkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wkg OCA], [http://pdbe.org/5wkg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wkg RCSB], [http://www.ebi.ac.uk/pdbsum/5wkg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wkg ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	</div>		</div>
	<div class="pdbe-citations 5wkg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5wkg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Gras, S]]		[[Category: Gras, S]]
	[[Category: Rossjohn, J]]		[[Category: Rossjohn, J]]

OCA at 06:04, 1 November 2017

OCA — Wed, 01 Nov 2017 06:04:45 GMT

←Older revision		Revision as of 06:04, 1 November 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5wkg is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal Structure of Human CD1b in Complex with PA==
		+	<StructureSection load='5wkg' size='340' side='right' caption='[[5wkg]], [[Resolution\|resolution]] 2.06Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5wkg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WKG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CUY:tetracosyl+octadecanoate'>CUY</scene>, <scene name='pdbligand=D21:(2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl+(9Z)-octadec-9-enoate'>D21</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wkg OCA], [http://pdbe.org/5wkg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wkg RCSB], [http://www.ebi.ac.uk/pdbsum/5wkg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wkg ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CD1B_HUMAN CD1B_HUMAN]] Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:10981968</ref> <ref>PMID:14716313</ref> [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human T cell autoreactivity toward lipid antigens presented by CD1 proteins can manifest in numerous diseases, including psoriasis, contact hypersensitivities, and allergies. However, the molecular mechanisms for regulating T cell autoreactivity toward lipid antigens remain unclear. We determined the basis for T cell receptor (TCR) autoreactivity toward CD1b bound to self-phospholipids. The spectrum of self-antigens captured by CD1b skews toward abundant membrane phospholipids such as phosphatidylcholine and phosphatidylethanolamine. However, TCRs can specifically recognize rare phospholipids, including phosphatidylglycerol (PG). The structure of an autoreactive TCR bound to CD1b-PG shows that discrimination occurs through a marked induced fit movement of PG so that its polar head group fits snugly into the cationic cup of the TCR. Conversely, TCR binding toward ubiquitous self-phospholipids was sterically or electrostatically repelled. Accordingly, we describe a mechanism of TCR autoreactivity toward rare phospholipids and avoidance of autoreactivity to the most abundant self-phospholipids.

-	~~Authors: Shahine,~~ A., ~~Gras~~, S., ~~Rossjohn~~, J.	+	A molecular basis of human T cell receptor autoreactivity toward self-phospholipids.,Shahine A, Van Rhijn I, Cheng TY, Iwany S, Gras S, Moody DB, Rossjohn J Sci Immunol. 2017 Oct 20;2(16). pii: eaao1384. doi: 10.1126/sciimmunol.aao1384. PMID:29054999<ref>PMID:29054999</ref>

-	~~Description: Crystal Structure~~ of ~~Human CD1b in Complex with PA~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 5wkg" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Gras, S]]		[[Category: Gras, S]]
-	[[Category: Shahine, A]]
	[[Category: Rossjohn, J]]		[[Category: Rossjohn, J]]
		+	[[Category: Shahine, A]]
		+	[[Category: Antigen presenting molecule]]
		+	[[Category: Cd1b]]
		+	[[Category: Immune system]]
		+	[[Category: Mhc]]
		+	[[Category: Pa]]
		+	[[Category: Phospholipid]]

OCA at 05:20, 11 October 2017

OCA — Wed, 11 Oct 2017 05:20:01 GMT

←Older revision		Revision as of 05:20, 11 October 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5wkg is ON HOLD	+	The entry 5wkg is ON HOLD until Paper Publication

	Authors: Shahine, A., Gras, S., Rossjohn, J.		Authors: Shahine, A., Gras, S., Rossjohn, J.
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	Description: Crystal Structure of Human CD1b in Complex with PA		Description: Crystal Structure of Human CD1b in Complex with PA
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Rossjohn, J]]
	[[Category: Gras, S]]		[[Category: Gras, S]]
	[[Category: Shahine, A]]		[[Category: Shahine, A]]
		+	[[Category: Rossjohn, J]]

OCA: Protected "5wkg" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 14:55:23 GMT

Protected "5wkg" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:55, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5wkg is ON HOLD Authors: Shahine, A., Gras, S., Rossjohn, J. Description: Crystal Structure of Human CD1b in Complex with PA [[Category: Unreleased...

OCA — Wed, 27 Sep 2017 14:55:22 GMT

New page: '''Unreleased structure''' The entry 5wkg is ON HOLD Authors: Shahine, A., Gras, S., Rossjohn, J. Description: Crystal Structure of Human CD1b in Complex with PA [[Category: Unreleased...

New page

'''Unreleased structure'''

The entry 5wkg is ON HOLD

Authors: Shahine, A., Gras, S., Rossjohn, J.

Description: Crystal Structure of Human CD1b in Complex with PA
[[Category: Unreleased Structures]]
[[Category: Rossjohn, J]]
[[Category: Gras, S]]
[[Category: Shahine, A]]