5wm4 - Revision history

OCA at 14:16, 4 October 2023

OCA — Wed, 04 Oct 2023 14:16:59 GMT

←Older revision		Revision as of 14:16, 4 October 2023
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	<StructureSection load='5wm4' size='340' side='right'caption='[[5wm4]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='5wm4' size='340' side='right'caption='[[5wm4]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wm4]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"streptomyces_gandocaensis"_park_et_al._2016 "streptomyces~~ gandocaensis~~" park et al. 2016~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WM4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5WM4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wm4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_gandocaensis Streptomyces gandocaensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WM4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=B5M:9-(5-O-{(S)-hydroxy[(2-hydroxy-6-methylbenzene-1-carbonyl)oxy]phosphoryl}-alpha-L-lyxofuranosyl)-9H-purin-6-amine'>B5M</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.781Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cahJ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1649596 "Streptomyces gandocaensis" Park et al. 2016])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=B5M:9-(5-O-{(S)-hydroxy[(2-hydroxy-6-methylbenzene-1-carbonyl)oxy]phosphoryl}-alpha-L-lyxofuranosyl)-9H-purin-6-amine'>B5M</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5wm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wm4 OCA], [~~http~~://pdbe.org/5wm4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5wm4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5wm4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5wm4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wm4 OCA], [https://pdbe.org/5wm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wm4 RCSB], [https://www.ebi.ac.uk/pdbsum/5wm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wm4 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A140DJY3_9ACTN A0A140DJY3_9ACTN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Streptomyces gandocaensis park et al. 2016]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Sikkema, A P~~]]	+	[[Category: Streptomyces gandocaensis]]
-	[[Category: ~~Smith, J L~~]]	+	[[Category: Sikkema AP]]
-	[[Category: ~~Adenylation domain]]~~	+	[[Category: Smith JL]]
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Peptide synthetase~~]]	+

OCA at 12:40, 25 December 2019

OCA — Wed, 25 Dec 2019 12:40:15 GMT

←Older revision		Revision as of 12:40, 25 December 2019
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	==Crystal Structure of CahJ in Complex with 6-Methylsalicyl Adenylate==		==Crystal Structure of CahJ in Complex with 6-Methylsalicyl Adenylate==
-	<StructureSection load='5wm4' size='340' side='right' caption='[[5wm4]], [[Resolution\|resolution]] 1.78Å' scene=''>	+	<StructureSection load='5wm4' size='340' side='right'caption='[[5wm4]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5wm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"streptomyces_gandocaensis"_park_et_al._2016 "streptomyces gandocaensis" park et al. 2016]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WM4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5wm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"streptomyces_gandocaensis"_park_et_al._2016 "streptomyces gandocaensis" park et al. 2016]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WM4 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Streptomyces gandocaensis park et al. 2016]]		[[Category: Streptomyces gandocaensis park et al. 2016]]
		+	[[Category: Large Structures]]
	[[Category: Sikkema, A P]]		[[Category: Sikkema, A P]]
	[[Category: Smith, J L]]		[[Category: Smith, J L]]

OCA at 07:34, 4 July 2018

OCA — Wed, 04 Jul 2018 07:34:42 GMT

←Older revision		Revision as of 07:34, 4 July 2018
Line 3:		Line 3:
	<StructureSection load='5wm4' size='340' side='right' caption='[[5wm4]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='5wm4' size='340' side='right' caption='[[5wm4]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wm4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WM4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"streptomyces_gandocaensis"_park_et_al._2016 "streptomyces gandocaensis" park et al. 2016]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WM4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=B5M:9-(5-O-{(S)-hydroxy[(2-hydroxy-6-methylbenzene-1-carbonyl)oxy]phosphoryl}-alpha-L-lyxofuranosyl)-9H-purin-6-amine'>B5M</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=B5M:9-(5-O-{(S)-hydroxy[(2-hydroxy-6-methylbenzene-1-carbonyl)oxy]phosphoryl}-alpha-L-lyxofuranosyl)-9H-purin-6-amine'>B5M</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cahJ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1649596 "Streptomyces gandocaensis" Park et al. 2016])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wm4 OCA], [http://pdbe.org/5wm4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wm4 RCSB], [http://www.ebi.ac.uk/pdbsum/5wm4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wm4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wm4 OCA], [http://pdbe.org/5wm4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wm4 RCSB], [http://www.ebi.ac.uk/pdbsum/5wm4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wm4 ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Streptomyces gandocaensis park et al. 2016]]
	[[Category: Sikkema, A P]]		[[Category: Sikkema, A P]]
	[[Category: Smith, J L]]		[[Category: Smith, J L]]

OCA at 07:16, 23 May 2018

OCA — Wed, 23 May 2018 07:16:09 GMT

←Older revision		Revision as of 07:16, 23 May 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5wm4 is ~~ON HOLD until Paper~~ Publication	+	==Crystal Structure of CahJ in Complex with 6-Methylsalicyl Adenylate==
		+	<StructureSection load='5wm4' size='340' side='right' caption='[[5wm4]], [[Resolution\|resolution]] 1.78Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5wm4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WM4 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=B5M:9-(5-O-{(S)-hydroxy[(2-hydroxy-6-methylbenzene-1-carbonyl)oxy]phosphoryl}-alpha-L-lyxofuranosyl)-9H-purin-6-amine'>B5M</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wm4 OCA], [http://pdbe.org/5wm4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wm4 RCSB], [http://www.ebi.ac.uk/pdbsum/5wm4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wm4 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cahuitamycins are biofilm inhibitors biosynthesized by a convergent NRPS pathway. Previous genetic analysis indicated that a discrete enzyme, CahJ, serves as a gatekeeper for cahuitamycin structural diversification. Herein, the CahJ protein was probed structurally, functionally and through mutasynthesis. This analysis enabled production of a new cahuitamycin congener through targeted precursor incorporation.

-	~~Authors~~:	+	A Defined and Flexible Pocket Explains Aryl Substrate Promiscuity by the Cahuitamycin Starter Unit Activating Enzyme CahJ.,Sherman DH, Tripathi A, Park SR, Sikkema A, Cho HJ, Wu J, Lee B, Xi C, Smith JL Chembiochem. 2018 May 9. doi: 10.1002/cbic.201800233. PMID:29742306<ref>PMID:29742306</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5wm4" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Sikkema, A P]]
		+	[[Category: Smith, J L]]
		+	[[Category: Adenylation domain]]
		+	[[Category: Ligase]]
		+	[[Category: Peptide synthetase]]

OCA: Protected "5wm4" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 14:58:30 GMT

Protected "5wm4" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:58, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5wm4 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Sep 2017 14:58:29 GMT

New page: '''Unreleased structure''' The entry 5wm4 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5wm4 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]