5wmh - Revision history

OCA at 14:17, 4 October 2023

OCA — Wed, 04 Oct 2023 14:17:21 GMT

←Older revision		Revision as of 14:17, 4 October 2023
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	<StructureSection load='5wmh' size='340' side='right'caption='[[5wmh]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='5wmh' size='340' side='right'caption='[[5wmh]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wmh]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WMH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5WMH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wmh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WMH FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=PLP:PYRIDOXAL~~-~~5-PHOSPHATE'>PLP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PAT, AAT, MEE17, At2g22250, T26C19.9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=5~~&id=3702 ARATH])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5wmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wmh OCA], [~~http~~://pdbe.org/5wmh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5wmh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5wmh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5wmh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wmh OCA], [https://pdbe.org/5wmh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wmh RCSB], [https://www.ebi.ac.uk/pdbsum/5wmh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wmh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PAT_ARATH PAT_ARATH]] Prokaryotic-type aspartate aminotransferase. Has also a prenate transaminase activity. Involved in the aromatic amino acids biosynthesis pathway via the arogenate route. Required for the transamination of prephenate into arogenate. Required for early development of the embryo.<ref>PMID:15634699</ref> <ref>PMID:16623902</ref> <ref>PMID:20883697</ref>	+	[https://www.uniprot.org/uniprot/PAT_ARATH PAT_ARATH] Prokaryotic-type aspartate aminotransferase. Has also a prenate transaminase activity. Involved in the aromatic amino acids biosynthesis pathway via the arogenate route. Required for the transamination of prephenate into arogenate. Required for early development of the embryo.<ref>PMID:15634699</ref> <ref>PMID:16623902</ref> <ref>PMID:20883697</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath~~]]	+	[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Holland~~, C K~~]]	+	[[Category: Holland CK]]
-	[[Category: Jez~~, J M]]~~	+	[[Category: Jez JM]]
-	~~[[Category: Aminotransferase]]~~	+
-	~~[[Category: Plp-dependent]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:12, 27 November 2019

OCA — Wed, 27 Nov 2019 08:12:29 GMT

←Older revision		Revision as of 08:12, 27 November 2019
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	==Arabidopsis thaliana prephenate aminotransferase==		==Arabidopsis thaliana prephenate aminotransferase==
-	<StructureSection load='5wmh' size='340' side='right' caption='[[5wmh]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='5wmh' size='340' side='right'caption='[[5wmh]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5wmh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WMH FirstGlance]. <br>		<table><tr><td colspan='2'>[[5wmh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WMH FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 5wmh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5wmh" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aspartate aminotransferase 3D structures\|Aspartate aminotransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Arath]]		[[Category: Arath]]
		+	[[Category: Large Structures]]
	[[Category: Holland, C K]]		[[Category: Holland, C K]]
	[[Category: Jez, J M]]		[[Category: Jez, J M]]

OCA at 07:37, 21 February 2019

OCA — Thu, 21 Feb 2019 07:37:49 GMT

←Older revision		Revision as of 07:37, 21 February 2019
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	<StructureSection load='5wmh' size='340' side='right' caption='[[5wmh]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='5wmh' size='340' side='right' caption='[[5wmh]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wmh]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WMH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wmh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WMH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PAT, AAT, MEE17, At2g22250, T26C19.9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wmh OCA], [http://pdbe.org/5wmh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wmh RCSB], [http://www.ebi.ac.uk/pdbsum/5wmh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wmh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wmh OCA], [http://pdbe.org/5wmh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wmh RCSB], [http://www.ebi.ac.uk/pdbsum/5wmh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wmh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PAT_ARATH PAT_ARATH]] Prokaryotic-type aspartate aminotransferase. Has also a prenate transaminase activity. Involved in the aromatic amino acids biosynthesis pathway via the arogenate route. Required for the transamination of prephenate into arogenate. Required for early development of the embryo.<ref>PMID:15634699</ref> <ref>PMID:16623902</ref> <ref>PMID:20883697</ref>		[[http://www.uniprot.org/uniprot/PAT_ARATH PAT_ARATH]] Prokaryotic-type aspartate aminotransferase. Has also a prenate transaminase activity. Involved in the aromatic amino acids biosynthesis pathway via the arogenate route. Required for the transamination of prephenate into arogenate. Required for early development of the embryo.<ref>PMID:15634699</ref> <ref>PMID:16623902</ref> <ref>PMID:20883697</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aromatic amino acids are protein building blocks and precursors to a number of plant natural products, such as the structural polymer lignin and a variety of medicinally relevant compounds. Plants make tyrosine and phenylalanine by a different pathway from many microbes; this pathway requires prephenate aminotransferase (PAT) as the key enzyme. Prephenate aminotransferase produces arogenate, the unique and immediate precursor for both tyrosine and phenylalanine in plants, and also has aspartate aminotransferase (AAT) activity. The molecular mechanisms governing the substrate specificity and activation or inhibition of PAT are currently unknown. Here we present the X-ray crystal structures of the wild-type and various mutants of PAT from Arabidopsis thaliana (AtPAT). Steady-state kinetic and ligand-binding analyses identified key residues, such as Glu108, that are involved in both keto acid and amino acid substrate specificities and probably contributed to the evolution of PAT activity among class Ib AAT enzymes. Structures of AtPAT mutants co-crystallized with either alpha-ketoglutarate or pyridoxamine 5'-phosphate and glutamate further define the molecular mechanisms underlying recognition of keto acid and amino acid substrates. Furthermore, cysteine was identified as an inhibitor of PAT from A. thaliana and Antirrhinum majus plants as well as the bacterium Chlorobium tepidum, uncovering a potential new effector of PAT.
		+
		+	Structural basis for substrate recognition and inhibition of prephenate aminotransferase from Arabidopsis.,Holland CK, Berkovich DA, Kohn ML, Maeda H, Jez JM Plant J. 2018 Apr;94(2):304-314. doi: 10.1111/tpj.13856. Epub 2018 Mar 14. PMID:29405514<ref>PMID:29405514</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5wmh" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arath]]
	[[Category: Holland, C K]]		[[Category: Holland, C K]]
	[[Category: Jez, J M]]		[[Category: Jez, J M]]

OCA at 21:40, 9 August 2018

OCA — Thu, 09 Aug 2018 21:40:32 GMT

←Older revision		Revision as of 21:40, 9 August 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 5wmh is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Arabidopsis thaliana prephenate aminotransferase==
-		+	<StructureSection load='5wmh' size='340' side='right' caption='[[5wmh]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5wmh]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WMH FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wmh OCA], [http://pdbe.org/5wmh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wmh RCSB], [http://www.ebi.ac.uk/pdbsum/5wmh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wmh ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PAT_ARATH PAT_ARATH]] Prokaryotic-type aspartate aminotransferase. Has also a prenate transaminase activity. Involved in the aromatic amino acids biosynthesis pathway via the arogenate route. Required for the transamination of prephenate into arogenate. Required for early development of the embryo.<ref>PMID:15634699</ref> <ref>PMID:16623902</ref> <ref>PMID:20883697</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Holland, C K]]
		+	[[Category: Jez, J M]]
		+	[[Category: Aminotransferase]]
		+	[[Category: Plp-dependent]]
		+	[[Category: Transferase]]

OCA at 05:55, 21 March 2018

OCA — Wed, 21 Mar 2018 05:55:00 GMT

←Older revision		Revision as of 05:55, 21 March 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5wmh is ON HOLD	+	The entry 5wmh is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5wmh" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 14:59:00 GMT

Protected "5wmh" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:59, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5wmh is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Sep 2017 14:58:59 GMT

New page: '''Unreleased structure''' The entry 5wmh is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5wmh is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]