5wnb - Revision history

OCA at 14:17, 4 October 2023

OCA — Wed, 04 Oct 2023 14:17:59 GMT

←Older revision		Revision as of 14:17, 4 October 2023
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	<StructureSection load='5wnb' size='340' side='right'caption='[[5wnb]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5wnb' size='340' side='right'caption='[[5wnb]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wnb]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human ~~Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WNB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5WNB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wnb]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_respiratory_syncytial_virus_A2 Human respiratory syncytial virus A2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WNB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5wnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wnb OCA], [~~http~~://pdbe.org/5wnb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5wnb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5wnb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5wnb ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wnb OCA], [https://pdbe.org/5wnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wnb RCSB], [https://www.ebi.ac.uk/pdbsum/5wnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wnb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GLYC_HRSVA GLYC_HRSVA]] Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities. Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors.	+	[https://www.uniprot.org/uniprot/GLYC_HRSVA GLYC_HRSVA] Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities. Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5wnb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5wnb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]	+	[[Category: Homo sapiens]]
		+	[[Category: Human respiratory syncytial virus A2]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: DuBois~~, R M~~]]	+	[[Category: DuBois RM]]
-	[[Category: Fedechkin~~, S O~~]]	+	[[Category: Fedechkin SO]]
-	[[Category: George~~, N L~~]]	+	[[Category: George NL]]
-	[[Category: Kauvar~~, L M~~]]	+	[[Category: Kauvar LM]]
-	[[Category: Wolff~~, J T]]~~	+	[[Category: Wolff JT]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: G glycoprotein]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Rsv]]~~	+
-	~~[[Category: Viral attachment protein]]~~	+
-	~~[[Category: Viral protein]]~~	+
-	~~[[Category: Viral protein-immune system complex~~]]	+

OCA at 07:13, 7 October 2020

OCA — Wed, 07 Oct 2020 07:13:16 GMT

←Older revision		Revision as of 07:13, 7 October 2020
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	==Structure of antibody 3D3 bound to the linear epitope of RSV G==		==Structure of antibody 3D3 bound to the linear epitope of RSV G==
-	<StructureSection load='5wnb' size='340' side='right' caption='[[5wnb]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='5wnb' size='340' side='right'caption='[[5wnb]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wnb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WNB OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5WNB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wnb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WNB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5WNB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5wnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wnb OCA], [http://pdbe.org/5wnb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wnb RCSB], [http://www.ebi.ac.uk/pdbsum/5wnb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wnb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5wnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wnb OCA], [http://pdbe.org/5wnb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wnb RCSB], [http://www.ebi.ac.uk/pdbsum/5wnb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wnb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: DuBois, R M]]		[[Category: DuBois, R M]]
	[[Category: Fedechkin, S O]]		[[Category: Fedechkin, S O]]

OCA at 07:56, 21 March 2018

OCA — Wed, 21 Mar 2018 07:56:55 GMT

←Older revision		Revision as of 07:56, 21 March 2018
Line 3:		Line 3:
	<StructureSection load='5wnb' size='340' side='right' caption='[[5wnb]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5wnb' size='340' side='right' caption='[[5wnb]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wnb]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WNB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wnb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WNB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wnb OCA], [http://pdbe.org/5wnb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wnb RCSB], [http://www.ebi.ac.uk/pdbsum/5wnb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wnb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wnb OCA], [http://pdbe.org/5wnb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wnb RCSB], [http://www.ebi.ac.uk/pdbsum/5wnb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wnb ProSAT]</span></td></tr>
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/GLYC_HRSVA GLYC_HRSVA]] Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities. Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors.		[[http://www.uniprot.org/uniprot/GLYC_HRSVA GLYC_HRSVA]] Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities. Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Respiratory syncytial virus (RSV) is a top cause of severe lower respiratory tract disease and mortality in young children and the elderly. The viral envelope G glycoprotein contributes to pathogenesis through its roles in host cell attachment and modulation of host immunity. Although the G glycoprotein is a target of protective RSV-neutralizing antibodies, its development as a vaccine antigen has been hindered by its heterogeneous glycosylation and sequence variability outside a conserved central domain (CCD). We describe the cocrystal structures of two high-affinity broadly neutralizing human monoclonal antibodies bound to the RSV G CCD. The antibodies bind to neighboring conformational epitopes, which we named antigenic sites gamma1 and gamma2, that span a highly conserved surface, illuminating an important region of vulnerability. We further show that isolated RSV G CCD activates the chemokine receptor CX3CR1 and that antibodies block this activity. These studies provide a template for rational vaccine design targeting this key contributor to RSV disease.
		+
		+	Structures of respiratory syncytial virus G antigen bound to broadly neutralizing antibodies.,Fedechkin SO, George NL, Wolff JT, Kauvar LM, DuBois RM Sci Immunol. 2018 Mar 9;3(21). pii: 3/21/eaar3534. doi:, 10.1126/sciimmunol.aar3534. Epub 2018 Mar 9. PMID:29523582<ref>PMID:29523582</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5wnb" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: DuBois, R M]]		[[Category: DuBois, R M]]
	[[Category: Fedechkin, S O]]		[[Category: Fedechkin, S O]]

OCA at 06:25, 14 March 2018

OCA — Wed, 14 Mar 2018 06:25:06 GMT

←Older revision		Revision as of 06:25, 14 March 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5wnb is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Structure of antibody 3D3 bound to the linear epitope of RSV G==
-		+	<StructureSection load='5wnb' size='340' side='right' caption='[[5wnb]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5wnb]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WNB FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wnb OCA], [http://pdbe.org/5wnb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wnb RCSB], [http://www.ebi.ac.uk/pdbsum/5wnb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wnb ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GLYC_HRSVA GLYC_HRSVA]] Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities. Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: DuBois, R M]]
		+	[[Category: Fedechkin, S O]]
		+	[[Category: George, N L]]
		+	[[Category: Kauvar, L M]]
		+	[[Category: Wolff, J T]]
		+	[[Category: Antibody]]
		+	[[Category: G glycoprotein]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Rsv]]
		+	[[Category: Viral attachment protein]]
		+	[[Category: Viral protein]]
		+	[[Category: Viral protein-immune system complex]]

OCA at 05:29, 17 January 2018

OCA — Wed, 17 Jan 2018 05:29:12 GMT

←Older revision		Revision as of 05:29, 17 January 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5wnb is ON HOLD	+	The entry 5wnb is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5wnb" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 15:00:30 GMT

Protected "5wnb" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:00, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5wnb is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Sep 2017 15:00:29 GMT

New page: '''Unreleased structure''' The entry 5wnb is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5wnb is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]