5wo7 - Revision history

OCA at 14:18, 4 October 2023

OCA — Wed, 04 Oct 2023 14:18:37 GMT

←Older revision		Revision as of 14:18, 4 October 2023
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	<StructureSection load='5wo7' size='340' side='right'caption='[[5wo7]], [[Resolution\|resolution]] 3.25Å' scene=''>		<StructureSection load='5wo7' size='340' side='right'caption='[[5wo7]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wo7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WO7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5WO7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wo7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WO7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DTB:6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC+ACID'>DTB</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.246Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Trpv6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DTB:6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC+ACID'>DTB</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5wo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wo7 OCA], [~~http~~://pdbe.org/5wo7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5wo7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5wo7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5wo7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wo7 OCA], [https://pdbe.org/5wo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wo7 RCSB], [https://www.ebi.ac.uk/pdbsum/5wo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wo7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TRPV6_RAT TRPV6_RAT]] Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).[UniProtKB:Q91WD2][UniProtKB:Q9H1D0]<ref>PMID:11287959</ref>	+	[https://www.uniprot.org/uniprot/TRPV6_RAT TRPV6_RAT] Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).[UniProtKB:Q91WD2][UniProtKB:Q9H1D0]<ref>PMID:11287959</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5wo7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5wo7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Saotome, K~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Singh, A~~ K]]	+	[[Category: Saotome K]]
-	[[Category: ~~Sobolevsky, A I~~]]	+	[[Category: Singh AK]]
-	[[Category: ~~Ion channel]]~~	+	[[Category: Sobolevsky AI]]
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Transporter~~]]	+

OCA at 09:42, 4 December 2019

OCA — Wed, 04 Dec 2019 09:42:56 GMT

←Older revision		Revision as of 09:42, 4 December 2019
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	==Crystal Structure of Transient Receptor Potential (TRP) channel TRPV6*==		==Crystal Structure of Transient Receptor Potential (TRP) channel TRPV6*==
-	<StructureSection load='5wo7' size='340' side='right' caption='[[5wo7]], [[Resolution\|resolution]] 3.25Å' scene=''>	+	<StructureSection load='5wo7' size='340' side='right'caption='[[5wo7]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wo7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WO7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WO7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DTB:6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC+ACID'>DTB</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DTB:6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC+ACID'>DTB</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Trpv6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wo7 OCA], [http://pdbe.org/5wo7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wo7 RCSB], [http://www.ebi.ac.uk/pdbsum/5wo7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wo7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wo7 OCA], [http://pdbe.org/5wo7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wo7 RCSB], [http://www.ebi.ac.uk/pdbsum/5wo7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wo7 ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Saotome, K]]		[[Category: Saotome, K]]
	[[Category: Singh, A K]]		[[Category: Singh, A K]]

OCA: Protected "5wo7" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 10:17:18 GMT

Protected "5wo7" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:17, 27 September 2017

OCA: New page: ==Crystal Structure of Transient Receptor Potential (TRP) channel TRPV6==
OCA — Wed, 27 Sep 2017 10:17:16 GMT

New page: ==Crystal Structure of Transient Receptor Potential (TRP) channel TRPV6== <StructureSection load='5wo7' size='340' side='right' caption='5wo7, resolution 3.25Å' ...

New page

==Crystal Structure of Transient Receptor Potential (TRP) channel TRPV6*==
<StructureSection load='5wo7' size='340' side='right' caption='[[5wo7]], [[Resolution|resolution]] 3.25Å' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5wo7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WO7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DTB:6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC+ACID'>DTB</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wo7 OCA], [http://pdbe.org/5wo7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wo7 RCSB], [http://www.ebi.ac.uk/pdbsum/5wo7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wo7 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/TRPV6_RAT TRPV6_RAT]] Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).[UniProtKB:Q91WD2][UniProtKB:Q9H1D0]<ref>PMID:11287959</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Tetrameric ion channels have either swapped or non-swapped arrangements of the S1-S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states.

Swapping of transmembrane domains in the epithelial calcium channel TRPV6.,Singh AK, Saotome K, Sobolevsky AI Sci Rep. 2017 Sep 6;7(1):10669. doi: 10.1038/s41598-017-10993-9. PMID:28878326<ref>PMID:28878326</ref>

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5wo7" style="background-color:#fffaf0;"></div>
== References ==
<references/>
TOC
</StructureSection>
[[Category: Saotome, K]]
[[Category: Singh, A K]]
[[Category: Sobolevsky, A I]]
[[Category: Ion channel]]
[[Category: Membrane protein]]
[[Category: Transporter]]